GenomeNet

Database: UniProt
Entry: Q29HT0
LinkDB: Q29HT0
Original site: Q29HT0 
ID   UBA5_DROPS              Reviewed;         397 AA.
AC   Q29HT0;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   12-SEP-2018, entry version 73.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme 5;
DE            Short=Ubiquitin-activating enzyme 5;
GN   ORFNames=GA14526;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA   Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA   van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA   Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA   Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA   Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA   Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA   Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura:
RT   chromosomal, gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- FUNCTION: E1-like enzyme which activates UFM1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC       subfamily. {ECO:0000305}.
DR   EMBL; CH379064; EAL31677.1; -; Genomic_DNA.
DR   RefSeq; XP_001354623.1; XM_001354587.3.
DR   RefSeq; XP_015041519.1; XM_015186033.1.
DR   ProteinModelPortal; Q29HT0; -.
DR   SMR; Q29HT0; -.
DR   STRING; 7237.FBpp0286306; -.
DR   PRIDE; Q29HT0; -.
DR   EnsemblMetazoa; FBtr0287868; FBpp0286306; FBgn0074554.
DR   EnsemblMetazoa; FBtr0365778; FBpp0329057; FBgn0074554.
DR   GeneID; 4814656; -.
DR   KEGG; dpo:Dpse_GA14526; -.
DR   FlyBase; FBgn0074554; Dpse\GA14526.
DR   InParanoid; Q29HT0; -.
DR   KO; K12164; -.
DR   OMA; ETHNYNI; -.
DR   PhylomeDB; Q29HT0; -.
DR   Proteomes; UP000001819; Partially assembled WGS sequence.
DR   Bgee; FBgn0074554; Expressed in 5 organ(s), highest expression level in male reproductive system.
DR   GO; GO:0019008; C:molybdopterin synthase complex; IEA:EnsemblMetazoa.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   GO; GO:0050905; P:neuromuscular process; IEA:EnsemblMetazoa.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; SSF69572; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Ubl conjugation pathway; Zinc.
FT   CHAIN         1    397       Ubiquitin-like modifier-activating enzyme
FT                                5.
FT                                /FTId=PRO_0000391947.
FT   ACT_SITE    243    243       Glycyl thioester intermediate.
FT                                {ECO:0000250}.
FT   METAL       219    219       Zinc. {ECO:0000250}.
FT   METAL       222    222       Zinc. {ECO:0000250}.
FT   METAL       296    296       Zinc. {ECO:0000250}.
FT   METAL       301    301       Zinc. {ECO:0000250}.
FT   BINDING      76     76       ATP; via amide nitrogen. {ECO:0000250}.
FT   BINDING      97     97       ATP. {ECO:0000250}.
FT   BINDING     120    120       ATP. {ECO:0000250}.
FT   BINDING     143    143       ATP. {ECO:0000250}.
FT   BINDING     177    177       ATP. {ECO:0000250}.
SQ   SEQUENCE   397 AA;  43528 MW;  410636D88DFB3A8D CRC64;
     MTNAIDELQA IIAELKTEVE EQRAVIRQSR DRIEHMSAEV VDSNPYSRLM ALQRMNIVKN
     YERIRDKTVA IVGVGGVGSV TADMLTRCGI GKLILFDYDK VELANMNRLF FTPDQAGLSK
     VEAAARTLTF INPDVRIETH NYNITTIDNF DNFLSTITGD GTVAGEPVDL VLSCVDNFEA
     RMAINAACNE KCLNWFESGV SENAVSGHIQ FLRPGDTACF ACAPPLVVAE NIDEKTLKRE
     GVCAASLPTT MGITAGFLVQ NALKYLLNFG EVSDYLGYNA LNDFFPKMTL KPNPQCDDRN
     CLLRQKEFQA RPKPVVVQEE APTDEPLHAS NDWGIELVAE DAPSDAPTDL SQSTDVGQGL
     RLAYEAPEKS SAEATQAATA PVDDTSLEDL MAQMKSM
//
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