ID Q29KC0_DROPS Unreviewed; 914 AA.
AC Q29KC0; A0A6I8UIY4;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2008, sequence version 2.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=DNA mismatch repair protein spellchecker 1 {ECO:0000313|RefSeq:XP_001356195.2};
GN Name=LOC4816708 {ECO:0000313|RefSeq:XP_001356195.2};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_001356195.2};
RN [1] {ECO:0000313|RefSeq:XP_001356195.2}
RP IDENTIFICATION.
RC STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_001356195.2};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_001356195.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
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DR RefSeq; XP_001356195.2; XM_001356159.4.
DR AlphaFoldDB; Q29KC0; -.
DR STRING; 46245.Q29KC0; -.
DR EnsemblMetazoa; FBtr0288919; FBpp0287357; FBgn0078047.
DR GeneID; 4816708; -.
DR KEGG; dpo:4816708; -.
DR eggNOG; KOG0219; Eukaryota.
DR HOGENOM; CLU_002472_10_0_1; -.
DR InParanoid; Q29KC0; -.
DR OMA; LVRFPQK; -.
DR Proteomes; UP000001819; Chromosome 4.
DR Bgee; FBgn0078047; Expressed in female reproductive system and 3 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819}.
FT DOMAIN 738..754
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 914 AA; 102804 MW; A04D0C6DFFB89D07 CRC64;
MQAKATESRR EPTLHMDTNA RRNFIKYHAK LGEKPSTTVR FYDHSDCYTV NGSDDCELVA
KIVYKSTAFI GALLPDDKET LQFVALSKGN FEMAVRELLL VRNLRVEVYV KRNEWQLEYR
GSPGNLLQFE DILFANKEVL VGNNMISLQV KLEGGAQRRV GVASVEQNDC QFQLLEFLDD
DFFTELEATV VLLGPKECLL PSVEGEYVPV KALLERNGVM ITVPKKSSAN DLLQDLNRLL
RFAKGQQEDA TGLKELQMLL ASESLKVAIK YLDLVNDAGN LGHYEIKQLD LKRFVHLDSA
AVGALNIMPK PGTHPSMPSY RWQSILGVLD HCRTPQGHRL MGKWVKQPLR SQEILNDRHN
IVECLLESSD TLESLSLDYL KRIPDILMLT KKLMRRKATL QDLFRIYQVI LRTPKIVQVL
LSLENSTVES VICSPFKSFL EDLTGLKQMV EQVVDFEAIE RGEYLVKSSF DSRLMELQQT
MNELYDKMER LKSKCNDELD LDSKQIKLEN VAKLGYHFRT TLKDDSVLRK NKNYRIVDVI
KGGVRFTSDK LEGYADEFAS CHSRYEEQQL SIVEEIIQVA VGYAAPLTSL NNELAQLDCL
VSFAIAARSA PTPYVRPNML AEGAGKLVLT DVRHPCLELQ EHVSFIANSV YFKKDKCNMF
IITGPNMGGK STYIRSVGTA VLMAHVGAFV PCGMATISMV DSILGRVGAS DNIIKGLSTF
MVEMIETSGI IRTATDKSLV IIDELGRGTS TYEGCGIAWS IAEHLAKETK CFTLFATHFH
EITKLAETLP TVKNCHMAAL ADADNFTLLY QVRPGVMEKS FGIQVARLAN FPEDVVQNAQ
EVYNEFEDEH ADKKNQEDKA LLEKIQVAIQ QLSTAGNNTE INVEDLTQLV TQFTQDIKQL
DSDYFKSVLA STEV
//
