ID Q29MN1_DROPS Unreviewed; 330 AA.
AC Q29MN1; A0A6I8UJP3;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Tumor suppressor candidate 3 {ECO:0000313|RefSeq:XP_001356598.1};
GN Name=LOC4816963 {ECO:0000313|RefSeq:XP_001356598.1};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_001356598.1};
RN [1] {ECO:0000313|RefSeq:XP_001356598.1}
RP IDENTIFICATION.
RC STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_001356598.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_001356598.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that
CC catalyzes the initial transfer of a defined glycan
CC (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-
CC pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr
CC consensus motif in nascent polypeptide chains, the first step in
CC protein N-glycosylation. N-glycosylation occurs cotranslationally and
CC the complex associates with the Sec61 complex at the channel-forming
CC translocon complex that mediates protein translocation across the
CC endoplasmic reticulum (ER). All subunits are required for a maximal
CC enzyme activity. {ECO:0000256|ARBA:ARBA00002791}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OST3/OST6 family.
CC {ECO:0000256|ARBA:ARBA00009561}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_001356598.1; XM_001356562.3.
DR AlphaFoldDB; Q29MN1; -.
DR SMR; Q29MN1; -.
DR STRING; 46245.Q29MN1; -.
DR EnsemblMetazoa; FBtr0282069; FBpp0280507; FBgn0080608.
DR GeneID; 4816963; -.
DR KEGG; dpo:4816963; -.
DR eggNOG; KOG2603; Eukaryota.
DR HOGENOM; CLU_052855_0_0_1; -.
DR InParanoid; Q29MN1; -.
DR OMA; VLFGMYS; -.
DR Proteomes; UP000001819; Chromosome 4.
DR Bgee; FBgn0080608; Expressed in female reproductive system and 2 other cell types or tissues.
DR ExpressionAtlas; Q29MN1; baseline.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016477; P:cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0035010; P:encapsulation of foreign target; IEA:EnsemblMetazoa.
DR GO; GO:1903830; P:magnesium ion transmembrane transport; IEA:EnsemblMetazoa.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR021149; OligosaccharylTrfase_OST3/OST6.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12692; DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR12692:SF0; GH11935P; 1.
DR Pfam; PF04756; OST3_OST6; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 330 AA; 36977 MW; DE3FF71A132F7B13 CRC64;
MRLVRNTLLG ALVVLAVCLI YAAAQAKPKT GLSLSEKVQN LVEMNAKKPL LRFNGPKFRE
YVKNSPRNYS MIVMLTALAP SRQCQICRHA HDEFAIVANS YRFSSVYSNK LFFAMVDFDE
GSEVFQLLRL NTAPVFMHFP AKGKPKGADT MDIHRVGFAA DSIAKFVAER VDVTIRIFRP
PNYSGTVAMI TLVALVGSFL YIRRNNLEFL YNKNLWGAIA VFFCFAMISG QMWNHIRGPP
LVHKSQNGGV AYIHGSSQGQ LVVETYIVMF LNAMIVLGMI LLIESGTSKG HNKNRIMAMV
GLVLVTVFFS FLLSVFRSKA QGYPYSFLFK
//
