ID Q29N69_DROPS Unreviewed; 897 AA.
AC Q29N69; A0A6I8UJB1;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Exocyst complex component 2 {ECO:0000256|ARBA:ARBA00017526, ECO:0000256|RuleBase:RU365069};
GN Name=LOC4817143 {ECO:0000313|RefSeq:XP_001356410.1};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_001356410.1};
RN [1] {ECO:0000313|RefSeq:XP_001356410.1}
RP IDENTIFICATION.
RC STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_001356410.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_001356410.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC {ECO:0000256|ARBA:ARBA00002660, ECO:0000256|RuleBase:RU365069}.
CC -!- SUBUNIT: Component of the exocyst complex.
CC {ECO:0000256|RuleBase:RU365069}.
CC -!- SIMILARITY: Belongs to the SEC5 family. {ECO:0000256|ARBA:ARBA00010578,
CC ECO:0000256|RuleBase:RU365069}.
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DR RefSeq; XP_001356410.1; XM_001356374.4.
DR AlphaFoldDB; Q29N69; -.
DR SMR; Q29N69; -.
DR STRING; 46245.Q29N69; -.
DR EnsemblMetazoa; FBtr0281923; FBpp0280361; FBgn0081350.
DR GeneID; 4817143; -.
DR KEGG; dpo:4817143; -.
DR eggNOG; KOG2347; Eukaryota.
DR HOGENOM; CLU_005811_1_0_1; -.
DR InParanoid; Q29N69; -.
DR OMA; RMWMDVD; -.
DR Proteomes; UP000001819; Chromosome 4.
DR Bgee; FBgn0081350; Expressed in female reproductive system and 2 other cell types or tissues.
DR GO; GO:0005642; C:annulate lamellae; IEA:EnsemblMetazoa.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:EnsemblMetazoa.
DR GO; GO:0000145; C:exocyst; IEA:UniProtKB-UniRule.
DR GO; GO:0031594; C:neuromuscular junction; IEA:EnsemblMetazoa.
DR GO; GO:0055037; C:recycling endosome; IEA:EnsemblMetazoa.
DR GO; GO:0016028; C:rhabdomere; IEA:EnsemblMetazoa.
DR GO; GO:0035003; C:subapical complex; IEA:EnsemblMetazoa.
DR GO; GO:0031267; F:small GTPase binding; IEA:EnsemblMetazoa.
DR GO; GO:0099641; P:anterograde axonal protein transport; IEA:EnsemblMetazoa.
DR GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0035147; P:branch fusion, open tracheal system; IEA:EnsemblMetazoa.
DR GO; GO:0007349; P:cellularization; IEA:EnsemblMetazoa.
DR GO; GO:0032456; P:endocytic recycling; IEA:EnsemblMetazoa.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0043001; P:Golgi to plasma membrane protein transport; IEA:EnsemblMetazoa.
DR GO; GO:0045087; P:innate immune response; IEA:EnsemblMetazoa.
DR GO; GO:0048599; P:oocyte development; IEA:EnsemblMetazoa.
DR GO; GO:0048215; P:positive regulation of Golgi vesicle fusion to target membrane; IEA:EnsemblMetazoa.
DR GO; GO:0071896; P:protein localization to adherens junction; IEA:EnsemblMetazoa.
DR GO; GO:0072697; P:protein localization to cell cortex; IEA:EnsemblMetazoa.
DR GO; GO:0090128; P:regulation of synapse maturation; IEA:EnsemblMetazoa.
DR GO; GO:0045056; P:transcytosis; IEA:EnsemblMetazoa.
DR CDD; cd00603; IPT_PCSR; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR029175; EXOC2/Sec5.
DR InterPro; IPR039481; EXOC2/Sec5_N_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR PANTHER; PTHR13043:SF1; EXOCYST COMPLEX COMPONENT 2; 1.
DR PANTHER; PTHR13043; EXOCYST COMPLEX COMPONENT SEC5; 1.
DR Pfam; PF15469; Sec5; 1.
DR Pfam; PF01833; TIG; 1.
DR SUPFAM; SSF81296; E set domains; 1.
PE 3: Inferred from homology;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483, ECO:0000256|RuleBase:RU365069};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|RuleBase:RU365069};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365069}.
FT DOMAIN 5..86
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|Pfam:PF01833"
FT DOMAIN 126..892
FT /note="Exocyst complex component EXOC2/Sec5 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF15469"
SQ SEQUENCE 897 AA; 100913 MW; C82CBD035E6C26D6 CRC64;
MAPQPVVTGL SPKEGPPGTR VIIRGEFLGT RVQDLIGLKI CGSDCLLSAE WKSSNKIIAR
TGPAKGKGDI IVTTLSGGVG TSTVQFRAYH ETIGPLKESA VWIEESPSQN FAWGRRTLTQ
SGLTQEDPLG LSIEGNEQKI PEDLRDLFPE ACGDLSQEHF SPSWFLLENH LATSFEDLKA
GLAYLKRKVE SQKEGQLSFL KSNAGSVIDQ LDTLMNIRDK LQEDLKLHGT EPLNILEASI
ENSITESQKI FTDVLVRKEK ADSTRSVLFA LSRHKFLFCL PNAVDRRAKA GEYDIVVNDY
SRAKNLFGKT EIPIFRKVLE EVDQRILSIR KQLHEKVVKM PQSVDQQKKL IKALTSLELQ
QSGTPIGDKL RNIDPAWDAI EARAKYLEAT FRQTFEQHAN KDAAGTPEKS KSRDRDRDPS
QAPSRVNFCE ELCDIAASQL PDLWRLGQLY FTGELRGPHD PKPGDFKKMI LNAIEKFCVY
LRLAILIAGD QRALRQSSGL SWSIGSASAT HQFLPWIPQC LRYTRIAYAT LIGLDLPSDA
LDIIQKLIDE VRLFCFSIIF KRSTDRCKKL GSQETWELGV EDYPGATILP AALEALLVET
LDEVQSVCMQ PESREGNLLE PQSDGQREVS QRLQEFLSTF SAVIEELAFQ SHDEETPTHN
VSQLLGFPNA QQLDSVASGG AAVTWEQRML CCLANYAYCN KSFFPHIGDV FVRYGYPLPT
LAIETSRYTV NQLFTNLLEE YVEHKGDPLV GTIEPSMYLG RFQWDHEMEI GQLRPYAHEC
CDNLVGVYSE IYSISPALLR PILESIVQTI SEELARLMSC VQRFSFTGAI QAHVDIRLLR
DALECYANET AKNYFMEALE AINPPLNVEQ KRKADEILER VKRNMRLQLL CFTIKEP
//
