GenomeNet

Database: UniProt
Entry: Q29RS8
LinkDB: Q29RS8
Original site: Q29RS8 
ID   FLI1_BOVIN              Reviewed;         452 AA.
AC   Q29RS8;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   07-OCT-2020, entry version 95.
DE   RecName: Full=Friend leukemia integration 1 transcription factor;
DE   AltName: Full=Proto-oncogene Fli-1;
GN   Name=FLI1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Sequence-specific transcriptional activator. Recognizes the
CC       DNA sequence 5'-C[CA]GGAAGT-3' (By similarity).
CC       {ECO:0000250|UniProtKB:Q01543}.
CC   -!- SUBUNIT: Can form homodimers or heterodimers with ETV6/TEL1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q01543}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
DR   EMBL; BC114042; AAI14043.1; -; mRNA.
DR   RefSeq; NP_001039763.1; NM_001046298.1.
DR   SMR; Q29RS8; -.
DR   STRING; 9913.ENSBTAP00000010899; -.
DR   PaxDb; Q29RS8; -.
DR   Ensembl; ENSBTAT00000076320; ENSBTAP00000068486; ENSBTAG00000008283.
DR   GeneID; 529124; -.
DR   KEGG; bta:529124; -.
DR   CTD; 2313; -.
DR   VGNC; VGNC:29031; FLI1.
DR   eggNOG; KOG3806; Eukaryota.
DR   GeneTree; ENSGT00940000158261; -.
DR   InParanoid; Q29RS8; -.
DR   KO; K09436; -.
DR   OrthoDB; 1113327at2759; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   ExpressionAtlas; Q29RS8; baseline and differential.
DR   GO; GO:0042025; C:host cell nucleus; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd08541; SAM_PNT-FLI-1; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR035575; Fli-1.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR035573; SAM_PNT-FLI-1.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849:SF161; PTHR11849:SF161; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Phosphoprotein; Proto-oncogene;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..452
FT                   /note="Friend leukemia integration 1 transcription factor"
FT                   /id="PRO_0000287135"
FT   DOMAIN          112..198
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        281..361
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   MOD_RES         39
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P26323"
SQ   SEQUENCE   452 AA;  50865 MW;  97BC9FABAFAC48EA CRC64;
     MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP LPPQQEWMNQ
     PVRVNVKREY DHMNGSRESP VDCSVSKCGK LVGGGESNTM SYTSYVDEKN GPPPPNMTTN
     ERRVIVPADP TLWTQEHVRQ WLEWAIKEYG LMEIDTSFFQ NMDGKELCKL NKEDFLRATS
     LYNTEVLLSH LTYLRESSLL PYNTTSHTDP SSRLNVKEDP SYDSVRRGGW GSNMNSGLNK
     SPPLAGAQTM SKNTEQRPQP DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSANASCI
     TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK VHGKRYAYKF
     DFHGIAQALQ PHPTESSMYK YPSDISYVPS YHTHQQKVNF VPPHPSSMPV TSSSFFGAAS
     QYWTSPTGGI YPNPNVPRHP NTHVPSHLGS YY
//
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