ID Q2AB80_XENTR Unreviewed; 300 AA.
AC Q2AB80;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=Taste receptor type 2 {ECO:0000256|RuleBase:RU004424};
GN Name=tas2r7 {ECO:0000313|RefSeq:NP_001165465.1,
GN ECO:0000313|Xenbase:XB-GENE-6464262};
GN Synonyms=t2r1 {ECO:0000313|RefSeq:NP_001165465.1}, t2r7
GN {ECO:0000313|RefSeq:NP_001165465.1}, trb4
GN {ECO:0000313|RefSeq:NP_001165465.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:BAE80387.1};
RN [1] {ECO:0000313|EMBL:BAE80387.1, ECO:0000313|RefSeq:NP_001165465.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16484289; DOI=10.1093/molbev/msj106;
RG SMBE Tri-National Young Investigators;
RA Go Y.;
RT "Lineage-specific expansions and contractions of the bitter taste receptor
RT gene repertoire in vertebrates.";
RL Mol. Biol. Evol. 23:964-972(2006).
RN [2] {ECO:0000313|RefSeq:NP_001165465.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004424}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000256|ARBA:ARBA00007376, ECO:0000256|RuleBase:RU004423}.
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DR EMBL; AB249769; BAE80387.1; -; Genomic_DNA.
DR RefSeq; NP_001165465.1; NM_001171994.1.
DR STRING; 8364.ENSXETP00000031608; -.
DR PaxDb; 8364-ENSXETP00000004553; -.
DR GeneID; 100335054; -.
DR KEGG; xtr:100335054; -.
DR AGR; Xenbase:XB-GENE-6464262; -.
DR CTD; 50837; -.
DR Xenbase; XB-GENE-6464262; tas2r7.
DR eggNOG; ENOG502S2SI; Eukaryota.
DR HOGENOM; CLU_072337_1_0_1; -.
DR OMA; WIMNDAM; -.
DR OrthoDB; 4189279at2759; -.
DR PhylomeDB; Q2AB80; -.
DR TreeFam; TF335891; -.
DR Proteomes; UP000008143; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033038; F:bitter taste receptor activity; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd13950; 7tm_TAS2R; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF47; TASTE RECEPTOR TYPE 2 MEMBER 1-RELATED; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU004424};
KW Membrane {ECO:0000256|RuleBase:RU004424, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU004424, ECO:0000313|EMBL:BAE80387.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW ECO:0000256|RuleBase:RU004424};
KW Taste {ECO:0000256|ARBA:ARBA00022480, ECO:0000256|RuleBase:RU004424};
KW Transducer {ECO:0000256|RuleBase:RU004424};
KW Transmembrane {ECO:0000256|RuleBase:RU004424, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..65
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 77..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..145
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 300 AA; 34437 MW; EEDA86C958A1493C CRC64;
MFSPFVTAMK ILCLAEFVMG ILLNAFIVVA NAVSWMERKP LDSIDLILTS LGLSRLALLI
TWLLYVLSED RYEHIEILNV MSSFFGFCSL WFGTVLCTFY CVKIPNYNHR FFLYVKLRIS
KMIPWLLLVS VTSSFISCLP IGWSMDSSMF HYNSTNGTNM ETTLYLQFFI YVAGNSVPFF
MFCVAITLLI RSLWNHTRQM AAGEVGFGTP QLQAHYSAIR CMMSFMVLYI IFSSSVFLAL
PMVLMNDTLL WLYLFIAGLY PSLHSHILIL SNRKLRRALC SLLSYTSTFI PQERNISPCQ
//
