ID Q2ABD6_CANLF Unreviewed; 295 AA.
AC Q2ABD6;
DT 04-APR-2006, integrated into UniProtKB/TrEMBL.
DT 04-APR-2006, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=Taste receptor type 2 {ECO:0000256|RuleBase:RU004424};
GN Name=TAS2R5 {ECO:0000313|Ensembl:ENSCAFP00845043218.1};
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615 {ECO:0000313|EMBL:BAE80331.1};
RN [1] {ECO:0000313|EMBL:BAE80331.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16484289; DOI=10.1093/molbev/msj106;
RG SMBE Tri-National Young Investigators;
RA Go Y.;
RT "Lineage-specific expansions and contractions of the bitter taste receptor
RT gene repertoire in vertebrates.";
RL Mol. Biol. Evol. 23:964-972(2006).
RN [2] {ECO:0000313|Ensembl:ENSCAFP00845043218.1}
RP IDENTIFICATION.
RC STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00845043218.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5. {ECO:0000256|ARBA:ARBA00024847}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004424}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000256|ARBA:ARBA00007376, ECO:0000256|RuleBase:RU004423}.
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DR EMBL; AB249688; BAE80331.1; -; Genomic_DNA.
DR RefSeq; NP_001138978.1; NM_001145506.1.
DR Ensembl; ENSCAFT00845054962.1; ENSCAFP00845043218.1; ENSCAFG00845030924.1.
DR GeneID; 100271743; -.
DR KEGG; cfa:100271743; -.
DR CTD; 54429; -.
DR VEuPathDB; HostDB:ENSCAFG00845030924; -.
DR eggNOG; ENOG502S2SI; Eukaryota.
DR GeneTree; ENSGT01100000263477; -.
DR HOGENOM; CLU_072337_1_1_1; -.
DR OMA; CRFLLQW; -.
DR OrthoDB; 5263908at2759; -.
DR TreeFam; TF335891; -.
DR Proteomes; UP000805418; Chromosome 16.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0033038; F:bitter taste receptor activity; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd13950; 7tm_TAS2R; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF8; TASTE RECEPTOR TYPE 2 MEMBER 5; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU004424};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004424};
KW Receptor {ECO:0000256|RuleBase:RU004424, ECO:0000313|EMBL:BAE80331.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000805418};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW ECO:0000256|RuleBase:RU004424};
KW Taste {ECO:0000256|ARBA:ARBA00022480, ECO:0000256|RuleBase:RU004424};
KW Transducer {ECO:0000256|RuleBase:RU004424};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU004424};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..274
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 295 AA; 33486 MW; B2A6762B9EC2AD45 CRC64;
MLTAALPLLM VVAVVEFLIG LVGNGVLMVW SFGEWVRKFN GSSYNLIVLG LAVCRFLLQC
LIMMDLSLFP FFQSSRWLHY LSIFWILVSQ ASLWFATFLS VFYCRKIMTL EHPVCLWLKQ
RAYCLSLWCL LVYLMISLLL VAHIGLKPYN PSQGNSSILY PLKSWHYLYI VKLNAGSGLP
LMVFLVSSGM LIVSLYRHHK KMEVHTAGRR DAQAKAHITV LKSLGCFLIL HVIYILASPF
SITSKSSADL LVVFISETVM AAYPSLHSVI LILGNPRMKQ TCQRILWKTV CAWKS
//
