ID Q2EN80_PIG Unreviewed; 128 AA.
AC Q2EN80;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 {ECO:0000256|ARBA:ARBA00018675};
DE AltName: Full=Complex I-B17 {ECO:0000256|ARBA:ARBA00030214};
DE AltName: Full=NADH-ubiquinone oxidoreductase B17 subunit {ECO:0000256|ARBA:ARBA00029949};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|EMBL:ABD18452.1};
RN [1] {ECO:0000313|EMBL:ABD18452.1}
RP NUCLEOTIDE SEQUENCE.
RA Chen C.H., Ding S.T.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0007829|PDB:5GUP}
RP STRUCTURE BY ELECTRON MICROSCOPY (4.00 ANGSTROMS).
RX PubMed=27912063; DOI=10.1016/j.cell.2016.11.012;
RA Wu M., Gu J., Guo R., Huang Y., Yang M.;
RT "Structure of Mammalian Respiratory Supercomplex
RT I<sub>1</sub>III<sub>2</sub>IV<sub>1</sub>.";
RL Cell 167:1598-1609.e10(2016).
RN [3] {ECO:0007829|PDB:7W0Y}
RP STRUCTURE BY ELECTRON MICROSCOPY (2.70 ANGSTROMS) OF 2-127.
RX PubMed=35145322; DOI=10.1038/s41594-022-00722-w;
RA Gu J., Liu T., Guo R., Zhang L., Yang M.;
RT "The coupling mechanism of mammalian mitochondrial complex I.";
RL Nat. Struct. Mol. Biol. 29:172-182(2022).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|ARBA:ARBA00003195}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000256|ARBA:ARBA00011533}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004298}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004298}; Matrix side
CC {ECO:0000256|ARBA:ARBA00004298}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB6 subunit family.
CC {ECO:0000256|ARBA:ARBA00007771}.
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DR EMBL; DQ372077; ABD18452.1; -; mRNA.
DR RefSeq; NP_001038019.1; NM_001044554.2.
DR PDB; 5GUP; EM; 4.00 A; b=1-128.
DR PDB; 7W0Y; EM; 3.40 A; b=2-127.
DR PDBsum; 5GUP; -.
DR AlphaFoldDB; Q2EN80; -.
DR EMDB; EMD-32187; -.
DR EMDB; EMD-32191; -.
DR EMDB; EMD-32197; -.
DR EMDB; EMD-32202; -.
DR EMDB; EMD-32204; -.
DR EMDB; EMD-32206; -.
DR EMDB; EMD-32214; -.
DR EMDB; EMD-32222; -.
DR EMDB; EMD-32230; -.
DR EMDB; EMD-32231; -.
DR EMDB; EMD-32232; -.
DR EMDB; EMD-32242; -.
DR EMDB; EMD-32248; -.
DR EMDB; EMD-32253; -.
DR EMDB; EMD-32254; -.
DR EMDB; EMD-9539; -.
DR SMR; Q2EN80; -.
DR PeptideAtlas; Q2EN80; -.
DR GeneID; 733605; -.
DR KEGG; ssc:733605; -.
DR CTD; 4712; -.
DR HOGENOM; CLU_171928_0_0_1; -.
DR OMA; KYHVNTK; -.
DR OrthoDB; 5382809at2759; -.
DR TreeFam; TF328587; -.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:InterPro.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR InterPro; IPR019174; NADH_DH_b-subcmplx_su6.
DR PANTHER; PTHR15083; NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 6; 1.
DR PANTHER; PTHR15083:SF0; NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 6; 1.
DR Pfam; PF09782; NDUF_B6; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:5GUP, ECO:0007829|PDB:7W0Y};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 68..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 128 AA; 15577 MW; 557B53CEB68FDAE2 CRC64;
MSGYTPDEKL RLQQLRELRR RWLKDQELSP REPVLPPRRV WPMEQFWNKF LQDGAPWKNV
IYKTYRHSIF AVTHVLIPVW IIHYYLKYHV TAKPYTVVER KPRIFPGDTI LETGEVIPLM
KEFPDQHH
//
