ID   Q2FS19_METHJ            Unreviewed;       546 AA.
AC   Q2FS19;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   SubName: Full=Pyruvate flavodoxin/ferredoxin oxidoreductase-like protein {ECO:0000313|EMBL:ABD42679.1};
GN   OrderedLocusNames=Mhun_2992 {ECO:0000313|EMBL:ABD42679.1};
OS   Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 /
OS   JF-1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales; Methanospirillaceae; Methanospirillum.
OX   NCBI_TaxID=323259 {ECO:0000313|EMBL:ABD42679.1, ECO:0000313|Proteomes:UP000001941};
RN   [1] {ECO:0000313|Proteomes:UP000001941}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27890 / DSM 864 / NBRC 100397 / JF-1
RC   {ECO:0000313|Proteomes:UP000001941};
RX   PubMed=26744606; DOI=10.1186/s40793-015-0124-8;
RA   Gunsalus R.P., Cook L.E., Crable B., Rohlin L., McDonald E., Mouttaki H.,
RA   Sieber J.R., Poweleit N., Zhou H., Lapidus A.L., Daligault H.E., Land M.,
RA   Gilna P., Ivanova N., Kyrpides N., Culley D.E., McInerney M.J.;
RT   "Complete genome sequence of Methanospirillum hungatei type strain JF1.";
RL   Stand. Genomic Sci. 11:2-2(2016).
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DR   EMBL; CP000254; ABD42679.1; -; Genomic_DNA.
DR   RefSeq; WP_011449932.1; NC_007796.1.
DR   AlphaFoldDB; Q2FS19; -.
DR   STRING; 323259.Mhun_2992; -.
DR   EnsemblBacteria; ABD42679; ABD42679; Mhun_2992.
DR   GeneID; 3922907; -.
DR   KEGG; mhu:Mhun_2992; -.
DR   eggNOG; arCOG01606; Archaea.
DR   HOGENOM; CLU_017038_1_0_2; -.
DR   InParanoid; Q2FS19; -.
DR   OrthoDB; 31112at2157; -.
DR   Proteomes; UP000001941; Chromosome.
DR   GO; GO:0016903; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors; IEA:InterPro.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.920.10; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR   InterPro; IPR022367; 2-oxoacid/accept_OxRdtase_asu.
DR   InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   NCBIfam; TIGR03710; OAFO_sf; 1.
DR   PANTHER; PTHR32154:SF20; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORA; 1.
DR   PANTHER; PTHR32154; PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR   Pfam; PF01558; POR; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   SUPFAM; SSF53323; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|EMBL:ABD42679.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001941}.
FT   DOMAIN          12..162
FT                   /note="Pyruvate/ketoisovalerate oxidoreductase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01558"
FT   DOMAIN          193..422
FT                   /note="Pyruvate flavodoxin/ferredoxin oxidoreductase
FT                   pyrimidine binding"
FT                   /evidence="ECO:0000259|Pfam:PF01855"
SQ   SEQUENCE   546 AA;  59222 MW;  958089F37695BDB9 CRC64;
     MAEFSVLIGG KAGDGISQAG QVIGSVFSSL GYHVYQYVDY PSLIRGGHNF CIIRAAEYPV
     TAFRSGVDVI IAFDQQTADL HKGRLSDDGI IISDADRVKA PGLEIPLGQL INTHQGIPIM
     GNTAMISALF RYLGVPWDRI EPVLKRKNPK KTEKNLEIAR AAWDILSPSR KLGIPGGSPK
     PFLSGNEWIG LGLLAGGLDA YVAYPMTPSS GILHFLASIA DEAGIQVYHP ESEIAVILMA
     LGFSYAGKKA AVGTSGGGFC LMTEGLSLAG QAEIPIVIVV SQRTGPSTGL PTYTAQSDLM
     FIRHAGQGEF PRWIAAPGTP EEAIFLGAEA VRIAWKFQVP AFIISDKTFS EGLFTGSADL
     PDLPPHRVSA PAFPYHRYED MPDGISPLLA PPHPGEVVKV NSYTHDFKGI TTEDPQITIA
     MVEKRKRKEL ALKEYTDQPE SIRITGNEKA PVCVIAWGSV RGQVAEIAKD NSFRFVSPLI
     LEPFPIKTFM AALEGVDRII VVEESATGQI DKILKEHGIV PDEIILRYDG RPSTIEELET
     RIRRVL
//