ID Q2FY53_STAA8 Unreviewed; 327 AA.
AC Q2FY53;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=2-oxoisovalerate dehydrogenase, E1 component, beta subunit, putative {ECO:0000313|EMBL:ABD30691.1};
DE EC=1.2.4.1 {ECO:0000313|EMBL:ABD30691.1};
GN OrderedLocusNames=SAOUHSC_01612 {ECO:0000313|EMBL:ABD30691.1};
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061 {ECO:0000313|EMBL:ABD30691.1, ECO:0000313|Proteomes:UP000008816};
RN [1] {ECO:0000313|Proteomes:UP000008816}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47 {ECO:0000313|Proteomes:UP000008816};
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C
RL (2006).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR EMBL; CP000253; ABD30691.1; -; Genomic_DNA.
DR RefSeq; WP_001096642.1; NZ_LS483365.1.
DR RefSeq; YP_500127.1; NC_007795.1.
DR AlphaFoldDB; Q2FY53; -.
DR SMR; Q2FY53; -.
DR STRING; 93061.SAOUHSC_01612; -.
DR PaxDb; 1280-SAXN108_1540; -.
DR GeneID; 3920028; -.
DR KEGG; sao:SAOUHSC_01612; -.
DR PATRIC; fig|93061.5.peg.1467; -.
DR eggNOG; COG0022; Bacteria.
DR HOGENOM; CLU_012907_1_0_9; -.
DR OrthoDB; 9771835at2; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IEA:UniProtKB-EC.
DR GO; GO:0009083; P:branched-chain amino acid catabolic process; IBA:GO_Central.
DR GO; GO:0007584; P:response to nutrient; IBA:GO_Central.
DR CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000313|EMBL:ABD30691.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008816}.
FT DOMAIN 4..179
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 327 AA; 36061 MW; 05D8A4194F3B3D33 CRC64;
MAKLSYLEAI RQAQDLALQQ NKDVFILGED VGRKGGVFGT TQGLQQKYGE DRVIDTPLAE
SNIVGTAIGA AMVGKRPIAE IQFADFILPA TNQIISEAAK MRYRSNNDWQ CPLTIRAPFG
GGVHGGLYHS QSIESIFASS PGLTIVIPST PYDAKGLLLS SIESNDPVLY FEHKKAYRFL
KEEVPEEYYT VPLGKADVKR EGEDLTVFCY GLMVNYCLQA ADILAADGIN VEVVDLRTVY
PLDKETIIDR AKHTGKVLLV TEDNLEGSIM SEVSAIIAEH CLFDLDAPIM RLAAPDVPSM
PFSPVLENEI MMNPEKILNK MRELAEF
//
