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Database: UniProt
Entry: Q2FYH5
LinkDB: Q2FYH5
Original site: Q2FYH5 
ID   DING_STAA8              Reviewed;         897 AA.
AC   Q2FYH5;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   18-SEP-2019, entry version 100.
DE   RecName: Full=3'-5' exonuclease DinG {ECO:0000255|HAMAP-Rule:MF_02206};
DE            EC=3.1.-.- {ECO:0000255|HAMAP-Rule:MF_02206};
GN   Name=dinG {ECO:0000255|HAMAP-Rule:MF_02206};
GN   OrderedLocusNames=SAOUHSC_01472;
OS   Staphylococcus aureus (strain NCTC 8325).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W.,
RA   Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press,
RL   Washington D.C. (2006).
RN   [2]
RP   INDUCTION.
RX   PubMed=11717293; DOI=10.1128/jb.183.24.7341-7353.2001;
RA   Dunman P.M., Murphy E., Haney S., Palacios D., Tucker-Kellogg G.,
RA   Wu S., Brown E.L., Zagursky R.J., Shlaes D., Projan S.J.;
RT   "Transcription profiling-based identification of Staphylococcus aureus
RT   genes regulated by the agr and/or sarA loci.";
RL   J. Bacteriol. 183:7341-7353(2001).
CC   -!- FUNCTION: 3'-5' exonuclease. {ECO:0000255|HAMAP-Rule:MF_02206}.
CC   -!- INDUCTION: Down-regulated by agr. {ECO:0000269|PubMed:11717293}.
CC   -!- SIMILARITY: Belongs to the helicase family. DinG subfamily. Type 2
CC       sub-subfamily. {ECO:0000255|HAMAP-Rule:MF_02206}.
DR   EMBL; CP000253; ABD30557.1; -; Genomic_DNA.
DR   RefSeq; WP_000525078.1; NZ_LS483365.1.
DR   RefSeq; YP_499990.1; NC_007795.1.
DR   SMR; Q2FYH5; -.
DR   STRING; 1280.SAXN108_1478; -.
DR   DNASU; 3919914; -.
DR   EnsemblBacteria; ABD30557; ABD30557; SAOUHSC_01472.
DR   GeneID; 3919914; -.
DR   KEGG; sao:SAOUHSC_01472; -.
DR   PATRIC; fig|93061.5.peg.1341; -.
DR   eggNOG; ENOG4105DVT; Bacteria.
DR   eggNOG; COG0847; LUCA.
DR   eggNOG; COG1199; LUCA.
DR   HOGENOM; HOG000280037; -.
DR   KO; K03722; -.
DR   OMA; VVTNHAM; -.
DR   BioCyc; GCF_000013425:G1I0R-1365-MONOMER; -.
DR   BioCyc; SAUR93061:G1G5Y-1365-MONOMER; -.
DR   PRO; PR:Q2FYH5; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0044776; C:DNA polymerase III, core complex; IBA:GO_Central.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   GO; GO:0045004; P:DNA replication proofreading; IBA:GO_Central.
DR   Gene3D; 3.30.420.10; -; 1.
DR   HAMAP; MF_02206; DinG_exonucl; 1.
DR   InterPro; IPR006555; ATP-dep_Helicase_C.
DR   InterPro; IPR006310; DinG.
DR   InterPro; IPR006054; DnaQ.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF13307; Helicase_C_2; 1.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SMART; SM00491; HELICc2; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   TIGRFAMs; TIGR01407; dinG_rel; 1.
DR   TIGRFAMs; TIGR00573; dnaq; 1.
DR   PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Exonuclease; Hydrolase; Nuclease;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN         1    897       3'-5' exonuclease DinG.
FT                                /FTId=PRO_0000273043.
FT   DOMAIN        8    161       Exonuclease. {ECO:0000255|HAMAP-
FT                                Rule:MF_02206}.
FT   DOMAIN      241    496       Helicase ATP-binding. {ECO:0000255|HAMAP-
FT                                Rule:MF_02206}.
FT   DOMAIN      703    893       Helicase C-terminal. {ECO:0000255|HAMAP-
FT                                Rule:MF_02206}.
FT   NP_BIND     276    283       ATP. {ECO:0000255|HAMAP-Rule:MF_02206}.
FT   MOTIF       448    451       DEAH box. {ECO:0000255|HAMAP-
FT                                Rule:MF_02206}.
SQ   SEQUENCE   897 AA;  104218 MW;  13D81550EDCB683D CRC64;
     MGMATYAVVD LETTGNQLDF DDIIQIGITF VRNNQIIDTY HSMIRTNLEI PPFIQALTSI
     EENMLQQAPY FNQVAQEIYD KIKDCIFVAH NVDFDLNFIK KAFKDCNIQY RPKKVIDTLE
     IFKIAFPTDK SYQLSELAEA HGITLANAHR ADEDAATTAK LMILAFEKFE KLPLDTLKQL
     YYLSKQLKYD LYDIFFEMVR QYDAKPLDKS YEKFEQIIYR KQVDFKKPTT NYNGSLKSLY
     SKAVDQLGLT YRPQQLYLAE TILDQLMHSE KAMIEASLGS GKSLAYLLAA LMYNIETGKH
     VMISTNTKLL QSQLLEKDIP AMNEALNFKI NALLIKSKSD YISLGLISQI LKDDTSNYEV
     NILKMQLLIW ITETPSGDIQ ELNLKGGQKM YFDQKIETYV PARHDVHYYN FIKRNAQNIQ
     IGITNHAHLI HSDVENSIYQ LFDDCIVDEA HRLPDYALNQ VTNELSYADI KYQLGLIGKN
     ENEKLLKAID QLEKQRILEK LDIAPIDIFG LKASMNEIHE LNEQLFSTIF TIINDSDVYD
     DDIHRFHNVF TFETKDILKD LHAIIDKLNK TLEIFNGISH KTVKSLRKQL LYLKDKFKNI
     EQSLKAGHTS FISIKNLSQK STIRLYVKDY AVKDVLTKQV LEKFKSLIFI SGTLKFNHSF
     EAFKQLFNKD VHFNTFEVNT SLQSAKNTSV FIPSDVASYQ YKNIDEYVAS IVSYIIEYTT
     ITSSKCLVLF TSYKMMHMVQ DMLNELPEFE DYVVLTQQQN QNYKIVQQFN NFDKAILLGT
     STFFEGFDFQ ANGIKCVMIA KLPFMNKHNA KYWLMDSEFT STFKEYVLPD AVTRFRQGLG
     RLIRNENDRG IIVSFDDRLI NSNYKNFFEQ TLENYRQKKG DIQQFGKLLR QIQKKKK
//
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