ID Q2FYL0_STAA8 Unreviewed; 166 AA.
AC Q2FYL0;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=PTS system glucose-specific EIIA component {ECO:0000256|ARBA:ARBA00039163};
DE AltName: Full=EIIA-Glc {ECO:0000256|ARBA:ARBA00042873};
DE AltName: Full=EIII-Glc {ECO:0000256|ARBA:ARBA00042526};
DE AltName: Full=Glucose-specific phosphotransferase enzyme IIA component {ECO:0000256|ARBA:ARBA00042296};
GN OrderedLocusNames=SAOUHSC_01430 {ECO:0000313|EMBL:ABD30522.1};
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061 {ECO:0000313|EMBL:ABD30522.1, ECO:0000313|Proteomes:UP000008816};
RN [1] {ECO:0000313|Proteomes:UP000008816}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47 {ECO:0000313|Proteomes:UP000008816};
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C
RL (2006).
CC -!- FUNCTION: The phosphoenolpyruvate-dependent sugar phosphotransferase
CC system (sugar PTS), a major carbohydrate active transport system,
CC catalyzes the phosphorylation of incoming sugar substrates
CC concomitantly with their translocation across the cell membrane. The
CC enzyme II complex composed of PtsG and Crr is involved in glucose
CC transport. {ECO:0000256|ARBA:ARBA00037252}.
CC -!- SUBUNIT: Heterodimer with glycerol kinase (glpk).
CC {ECO:0000256|ARBA:ARBA00038632}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CP000253; ABD30522.1; -; Genomic_DNA.
DR RefSeq; WP_000473652.1; NZ_LS483365.1.
DR RefSeq; YP_499955.1; NC_007795.1.
DR AlphaFoldDB; Q2FYL0; -.
DR SMR; Q2FYL0; -.
DR STRING; 93061.SAOUHSC_01430; -.
DR PaxDb; 1280-SAXN108_1443; -.
DR GeneID; 3920211; -.
DR KEGG; sao:SAOUHSC_01430; -.
DR PATRIC; fig|93061.5.peg.1306; -.
DR eggNOG; COG2190; Bacteria.
DR HOGENOM; CLU_012312_5_3_9; -.
DR OrthoDB; 92465at2; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016301; F:kinase activity; IBA:GO_Central.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 2.70.70.10; Glucose Permease (Domain IIA); 1.
DR InterPro; IPR011055; Dup_hybrid_motif.
DR InterPro; IPR001127; PTS_EIIA_1_perm.
DR NCBIfam; TIGR00830; PTBA; 1.
DR PANTHER; PTHR45008; PTS SYSTEM GLUCOSE-SPECIFIC EIIA COMPONENT; 1.
DR PANTHER; PTHR45008:SF1; PTS SYSTEM GLUCOSE-SPECIFIC EIIA COMPONENT; 1.
DR Pfam; PF00358; PTS_EIIA_1; 1.
DR SUPFAM; SSF51261; Duplicated hybrid motif; 1.
DR PROSITE; PS51093; PTS_EIIA_TYPE_1; 1.
DR PROSITE; PS00371; PTS_EIIA_TYPE_1_HIS; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Reference proteome {ECO:0000313|Proteomes:UP000008816};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 34..138
FT /note="PTS EIIA type-1"
FT /evidence="ECO:0000259|PROSITE:PS51093"
SQ SEQUENCE 166 AA; 17961 MW; A903D3E7AA202982 CRC64;
MFKKLFGKGK EVQKDIAIYA PLTGEFVKIE DIPDPVFAQK MMGEGFGINP TEGEVVSPIA
GRVDNVFPTK HAIGLKADNG LELLVHIGLD TVQLDGEGFE VLVSSGDEVN VGDPLVRFNL
EYINNNAKSV ISPIIITNTD QAASINIYDE NAVIKGETKV IDVTMN
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