ID Q2FYY7_STAA8 Unreviewed; 122 AA.
AC Q2FYY7;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE RecName: Full=HTH merR-type domain-containing protein {ECO:0000259|PROSITE:PS50937};
GN OrderedLocusNames=SAOUHSC_01285 {ECO:0000313|EMBL:ABD30385.1};
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061 {ECO:0000313|EMBL:ABD30385.1, ECO:0000313|Proteomes:UP000008816};
RN [1] {ECO:0000313|Proteomes:UP000008816}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47 {ECO:0000313|Proteomes:UP000008816};
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington D.C
RL (2006).
RN [2] {ECO:0007829|PDB:7TEA}
RP X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 1-83 IN COMPLEX WITH CA(2+).
RX PubMed=35778410; DOI=10.1038/s41467-022-31573-0;
RA Travis B.A., Peck J.V., Salinas R., Dopkins B., Lent N., Nguyen V.D.,
RA Borgnia M.J., Brennan R.G., Schumacher M.A.;
RT "Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory
RT circuitry in Gram-positive bacteria.";
RL Nat. Commun. 13:3793-3793(2022).
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DR EMBL; CP000253; ABD30385.1; -; Genomic_DNA.
DR RefSeq; WP_000624945.1; NZ_LS483365.1.
DR RefSeq; YP_499817.1; NC_007795.1.
DR PDB; 7TEA; X-ray; 2.35 A; A/B/C/E=1-83.
DR AlphaFoldDB; Q2FYY7; -.
DR SMR; Q2FYY7; -.
DR STRING; 93061.SAOUHSC_01285; -.
DR PaxDb; 1280-SAXN108_1313; -.
DR GeneID; 3920172; -.
DR GeneID; 66839500; -.
DR KEGG; sao:SAOUHSC_01285; -.
DR PATRIC; fig|93061.5.peg.1178; -.
DR eggNOG; COG0789; Bacteria.
DR HOGENOM; CLU_060077_9_0_9; -.
DR OrthoDB; 9806513at2; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd01105; HTH_GlnR-like; 1.
DR Gene3D; 1.10.1660.10; -; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR InterPro; IPR047057; MerR_fam.
DR PANTHER; PTHR30204:SF65; HTH-TYPE TRANSCRIPTIONAL REGULATOR TNRA; 1.
DR PANTHER; PTHR30204; REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR; 1.
DR Pfam; PF13411; MerR_1; 1.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:7TEA}; Calcium {ECO:0007829|PDB:7TEA};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0007829|PDB:7TEA};
KW Reference proteome {ECO:0000313|Proteomes:UP000008816}.
FT DOMAIN 13..81
FT /note="HTH merR-type"
FT /evidence="ECO:0000259|PROSITE:PS50937"
FT BINDING 43
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0007829|PDB:7TEA"
SQ SEQUENCE 122 AA; 14277 MW; D8C71775CCE832B7 CRC64;
MISNDAIRRN MAVFSMSVVS KLTDLTPRQI RYYETHELIK PERTEGQKRL FSLNDLERLL
EIKSLLEKGF NIKGIKQIIY DSQEHLTTDE QEIRKKMIVD ATQKPIGETL PINRGDLSRF
IK
//
