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Database: UniProt
Entry: Q2G0G1
LinkDB: Q2G0G1
Original site: Q2G0G1 
ID   ADH_STAA8               Reviewed;         336 AA.
AC   Q2G0G1;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   13-FEB-2019, entry version 88.
DE   RecName: Full=Alcohol dehydrogenase;
DE            Short=ADH;
DE            EC=1.1.1.1;
GN   Name=adh; OrderedLocusNames=SAOUHSC_00608;
OS   Staphylococcus aureus (strain NCTC 8325).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W.,
RA   Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press,
RL   Washington D.C. (2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH;
CC         Xref=Rhea:RHEA:10736, ChEBI:CHEBI:15378, ChEBI:CHEBI:15734,
CC         ChEBI:CHEBI:17478, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC         EC=1.1.1.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a secondary alcohol + NAD(+) = a ketone + H(+) + NADH;
CC         Xref=Rhea:RHEA:10740, ChEBI:CHEBI:15378, ChEBI:CHEBI:17087,
CC         ChEBI:CHEBI:35681, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC         EC=1.1.1.1;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000250};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000305}.
DR   EMBL; CP000253; ABD29746.1; -; Genomic_DNA.
DR   RefSeq; WP_001200748.1; NZ_LS483365.1.
DR   RefSeq; YP_499171.1; NC_007795.1.
DR   ProteinModelPortal; Q2G0G1; -.
DR   SMR; Q2G0G1; -.
DR   STRING; 93061.SAOUHSC_00608; -.
DR   EnsemblBacteria; ABD29746; ABD29746; SAOUHSC_00608.
DR   GeneID; 3918927; -.
DR   KEGG; sao:SAOUHSC_00608; -.
DR   PATRIC; fig|93061.5.peg.545; -.
DR   eggNOG; ENOG4105DQ4; Bacteria.
DR   eggNOG; COG1064; LUCA.
DR   HOGENOM; HOG000294685; -.
DR   KO; K13953; -.
DR   OMA; GLKMTDT; -.
DR   BioCyc; GCF_000013425:G1I0R-568-MONOMER; -.
DR   BioCyc; SAUR93061:G1G5Y-568-MONOMER; -.
DR   PRO; PR:Q2G0G1; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0004022; F:alcohol dehydrogenase (NAD) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR013149; ADH_C.
DR   InterPro; IPR013154; ADH_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Metal-binding; NAD; Oxidoreductase;
KW   Reference proteome; Zinc.
FT   CHAIN         1    336       Alcohol dehydrogenase.
FT                                /FTId=PRO_0000273033.
FT   METAL        37     37       Zinc 1; catalytic. {ECO:0000250}.
FT   METAL        58     58       Zinc 1; catalytic. {ECO:0000250}.
FT   METAL        89     89       Zinc 2. {ECO:0000250}.
FT   METAL        92     92       Zinc 2. {ECO:0000250}.
FT   METAL        95     95       Zinc 2. {ECO:0000250}.
FT   METAL       103    103       Zinc 2. {ECO:0000250}.
FT   METAL       145    145       Zinc 1; catalytic. {ECO:0000250}.
SQ   SEQUENCE   336 AA;  36048 MW;  DB68A432F9E72EF9 CRC64;
     MRAAVVTKDH KVSIEDKKLR ALKPGEALVQ TEYCGVCHTD LHVKNADFGD VTGVTLGHEG
     IGKVIEVAED VESLKIGDRV SIAWMFESCG RCEYCTTGRE TLCRSVKNAG YTVDGAMAEQ
     VIVTADYAVK VPEKLDPAAA SSITCAGVTT YKAVKVSNVK PGQWLGVFGI GGLGNLALQY
     AKNVMGAKIV AFDINDDKLA FAKELGADAI INSKDVDPVA EVMKLTDNKG LDATVVTSVA
     KTPFNQAVDV VKAGARVVAV GLPVDKMNLD IPRLVLDGIE VVGSLVGTRQ DLREAFEFAA
     ENKVTPKVQL RKLEEINDIF EEMENGTITG RMVIKF
//
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