ID Q2G751_NOVAD Unreviewed; 501 AA.
AC Q2G751;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:ABD26322.1};
GN OrderedLocusNames=Saro_1882 {ECO:0000313|EMBL:ABD26322.1};
OS Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG
OS 56034 / CIP 105152 / NBRC 16084 / F199).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=279238 {ECO:0000313|EMBL:ABD26322.1, ECO:0000313|Proteomes:UP000009134};
RN [1] {ECO:0000313|Proteomes:UP000009134}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084
RC / F199 {ECO:0000313|Proteomes:UP000009134};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N.,
RA Fredrickson J., Balkwill D., Romine M.F., Richardson P.;
RT "Complete sequence of Novosphingobium aromaticivorans DSM 12444.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP000248; ABD26322.1; -; Genomic_DNA.
DR RefSeq; WP_011445532.1; NC_007794.1.
DR AlphaFoldDB; Q2G751; -.
DR STRING; 279238.Saro_1882; -.
DR KEGG; nar:Saro_1882; -.
DR eggNOG; COG0665; Bacteria.
DR HOGENOM; CLU_022247_1_0_5; -.
DR Proteomes; UP000009134; Chromosome.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000009134}.
FT ACT_SITE 81
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 16..19
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 81
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 336
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 345
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 349
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 501 AA; 56591 MW; 131BB3E10D7672DD CRC64;
MATSDRTIRS VAIVGGGTAG WMTAAALAQA LRHNCRITLV ESDDIGTVGV GEATIPPIRT
FNETLQIDER EFVRKTQGTF KLGIEFVDWA RVGNRYFHPF GPHGRAFDMV NLHHYWLRAR
AEGETAPLDE HSMAWALARE NRFAPPMPDQ RNVLSTFDFA YHFDAGLYAR FLREYAEARG
VVRIEGKIGS VQQNGETGFV TGVTLEDGRA VEAELFVDCS GFRGLLIEGA LQAGYEDWTH
WLPCDRAMAV PCENAYPLTP YTRSTAREAG WQWRIPLQHR TGNGYVFCSQ FLSEDEAAEK
LLSRLDGKAL ADPRPLRFVT GRRKKFWDRN VIAIGLSSGF MEPLESTSIH LIQAGISKLL
ALFPDRGFDP IVIDEYNRIA VSEFERIRDF IILHYKLTER DDAELWRYCA AMDIPDTLKT
KIEHFRSFGR LVQRDADLFG PPSWLAVHIG QLNFPERTDP LADYRGIDGR EWLAKLRAAM
HHAAMQQPTH EQFIAANCAA A
//
