ID Q2GC22_NOVAD Unreviewed; 441 AA.
AC Q2GC22;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=Aminopeptidase P, Metallo peptidase, MEROPS family M24B {ECO:0000313|EMBL:ABD24601.1};
DE EC=3.4.11.9 {ECO:0000313|EMBL:ABD24601.1};
GN OrderedLocusNames=Saro_0152 {ECO:0000313|EMBL:ABD24601.1};
OS Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG
OS 56034 / CIP 105152 / NBRC 16084 / F199).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=279238 {ECO:0000313|EMBL:ABD24601.1, ECO:0000313|Proteomes:UP000009134};
RN [1] {ECO:0000313|Proteomes:UP000009134}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084
RC / F199 {ECO:0000313|Proteomes:UP000009134};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA Vergez L., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N.,
RA Fredrickson J., Balkwill D., Romine M.F., Richardson P.;
RT "Complete sequence of Novosphingobium aromaticivorans DSM 12444.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
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DR EMBL; CP000248; ABD24601.1; -; Genomic_DNA.
DR RefSeq; WP_011443815.1; NC_007794.1.
DR AlphaFoldDB; Q2GC22; -.
DR STRING; 279238.Saro_0152; -.
DR KEGG; nar:Saro_0152; -.
DR eggNOG; COG0006; Bacteria.
DR HOGENOM; CLU_017266_1_0_5; -.
DR Proteomes; UP000009134; Chromosome.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd01087; Prolidase; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 1.
DR InterPro; IPR007865; Aminopep_P_N.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR InterPro; IPR006311; TAT_signal.
DR PANTHER; PTHR43226; XAA-PRO AMINOPEPTIDASE 3; 1.
DR PANTHER; PTHR43226:SF4; XAA-PRO AMINOPEPTIDASE 3; 1.
DR Pfam; PF05195; AMP_N; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR SMART; SM01011; AMP_N; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
DR PROSITE; PS51318; TAT; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:ABD24601.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:ABD24601.1};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000009134};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..441
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004208200"
FT DOMAIN 41..176
FT /note="Aminopeptidase P N-terminal"
FT /evidence="ECO:0000259|SMART:SM01011"
SQ SEQUENCE 441 AA; 47295 MW; 68D831BDE50D9816 CRC64;
MTFTRRSLLA GAAATASLAV TARAQVIPPP GFATPSGTFP FPPEVYRERR ARLMSVLKDG
VAVIHGAPRD QTGGPVSPPF HQSGDFAWLT GIADEPGAVL VLAPDERTFR EFLLLPSRDI
ETERWDVERL PLGSLIEART GMQRVRRTGS LDALVTQIAA RSRTLHFMGP IVSASAPVPP
AMDLYGRIMA RVPGCTLKDQ SALLPSLRTV KEPRELDLMR KALAATQAGH LAAMKAVRPG
MTERQLTAVL EDGFRQGGGE GLSYDSIVAT GRNAASLHYA HGNATIGSQD LVLIDAAASV
GGYACDITRT FPASGRFTAA QRADYELVLA AQDAAARLLK PGVIHEDMTE AANAVFRKAG
RIDEFTHGLG HFVGLDVHDA GDYAKPIPAG AVLTIEPGLY NQQMNQGIRI EDLYLVTANG
CERLSTGIPR TVQEIEAFMV R
//
