ID   Q2GD31_NEOSM            Unreviewed;       641 AA.
AC   Q2GD31;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   SubName: Full=Type IV secretion system protein VirD4 {ECO:0000313|EMBL:ABD45644.1};
GN   Name=virD4 {ECO:0000313|EMBL:ABD45644.1};
GN   OrderedLocusNames=NSE_0739 {ECO:0000313|EMBL:ABD45644.1};
OS   Neorickettsia sennetsu (strain ATCC VR-367 / Miyayama) (Ehrlichia
OS   sennetsu).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Neorickettsia.
OX   NCBI_TaxID=222891 {ECO:0000313|EMBL:ABD45644.1, ECO:0000313|Proteomes:UP000001942};
RN   [1] {ECO:0000313|EMBL:ABD45644.1, ECO:0000313|Proteomes:UP000001942}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-367 / Miyayama {ECO:0000313|Proteomes:UP000001942};
RX   PubMed=16482227; DOI=10.1371/journal.pgen.0020021;
RA   Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V.,
RA   Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M.,
RA   Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.,
RA   Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J., Daugherty S.C.,
RA   Davidsen T., Durkin A.S., Gwinn M., Haft D.H., Selengut J.D.,
RA   Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R.,
RA   Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H.;
RT   "Comparative genomics of emerging human ehrlichiosis agents.";
RL   PLoS Genet. 2:208-222(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the VirD4/TraG family.
CC       {ECO:0000256|ARBA:ARBA00008806}.
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DR   EMBL; CP000237; ABD45644.1; -; Genomic_DNA.
DR   RefSeq; WP_011452121.1; NC_007798.1.
DR   AlphaFoldDB; Q2GD31; -.
DR   STRING; 222891.NSE_0739; -.
DR   KEGG; nse:NSE_0739; -.
DR   eggNOG; COG3505; Bacteria.
DR   HOGENOM; CLU_012039_2_1_5; -.
DR   OrthoDB; 9759295at2; -.
DR   Proteomes; UP000001942; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003688; TraG/VirD4.
DR   PANTHER; PTHR37937; CONJUGATIVE TRANSFER: DNA TRANSPORT; 1.
DR   PANTHER; PTHR37937:SF1; CONJUGATIVE TRANSFER: DNA TRANSPORT; 1.
DR   Pfam; PF02534; T4SS-DNA_transf; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        7..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          571..641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        571..590
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..641
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   641 AA;  73352 MW;  D844FAAC0C9988E6 CRC64;
     MRQLRNIITI FFLLAFIFAL ALYMSAAIFV VAVWGIEHLN FRDLQPSLDG FPTRLWPTIF
     VYISDLFNNW DAWAPAVKIK LAVSLGIPFG ILGVVFYMLR APIMEWRPFK KKESVHGDAR
     WATEREIRKI GLRSRKGILL GKDKKGFLIA GGFQHALLFA PTGSGKGVGF VIPNLLFWED
     SVVVHDIKLE NFTLTSGYRK KMGQKVYCWS PADPDGKSHC YNPLDWVSSK PGQMVDDVQK
     IANLLMPEQD FWVNEARSLF LGVVLYILAV PEKVKSFGEV VRVMRSDDVT YSLAVALDTM
     GKKIHPVAYM NIAAFLQKAD KERSGVISTM NSSLELWANP LIDTTTATSD FNFMKFKREL
     TTVYVGLTPD NLTRLQPLMQ VFYQQATEFL CRHLPQKDEP YGVLFMMDEF PTLGEMEQFK
     TGIAYFRGYN VRLFLIIQDT EQLKGIYEEA GMNSFLSNST YRITFAANNI ETANLISQLV
     GNKTVAQESL NKPKFLDLNP ASRSLHISET QRALLLPQEV IMLPRDQQIL LIESTYPIKS
     KKIRYFEDSF FTKKILDPIS IPTQEPFDPK KFEEKMRKER EAKELEENAP LAIDEDQALL
     EDESLLDDSD YEDGDFEDLD EEEDLSDFLD DTDEENEENM V
//