ID Q2GFN0_EHRCR Unreviewed; 540 AA.
AC Q2GFN0;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 24-JAN-2024, entry version 90.
DE SubName: Full=Metallo-beta-lactamase family, beta-CASP subfamily {ECO:0000313|EMBL:ABD45297.1};
GN OrderedLocusNames=ECH_0966 {ECO:0000313|EMBL:ABD45297.1};
OS Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Ehrlichia.
OX NCBI_TaxID=205920 {ECO:0000313|EMBL:ABD45297.1, ECO:0000313|Proteomes:UP000008320};
RN [1] {ECO:0000313|EMBL:ABD45297.1, ECO:0000313|Proteomes:UP000008320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC CRL-10679 / Arkansas {ECO:0000313|Proteomes:UP000008320};
RX PubMed=16482227; DOI=10.1371/journal.pgen.0020021;
RA Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V.,
RA Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M.,
RA Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.,
RA Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J., Daugherty S.C.,
RA Davidsen T., Durkin A.S., Gwinn M., Haft D.H., Selengut J.D.,
RA Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R.,
RA Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H.;
RT "Comparative genomics of emerging human ehrlichiosis agents.";
RL PLoS Genet. 2:208-222(2006).
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DR EMBL; CP000236; ABD45297.1; -; Genomic_DNA.
DR RefSeq; WP_006010370.1; NC_007799.1.
DR AlphaFoldDB; Q2GFN0; -.
DR STRING; 205920.ECH_0966; -.
DR KEGG; ech:ECH_0966; -.
DR eggNOG; COG0595; Bacteria.
DR HOGENOM; CLU_008727_3_3_5; -.
DR OMA; KNTCVFE; -.
DR OrthoDB; 9770211at2; -.
DR Proteomes; UP000008320; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd07714; RNaseJ_MBL-fold; 1.
DR Gene3D; 3.10.20.580; -; 1.
DR Gene3D; 3.40.50.10710; Metallo-hydrolase/oxidoreductase; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR011108; RMMBL.
DR InterPro; IPR004613; RNase_J.
DR InterPro; IPR042173; RNase_J_2.
DR InterPro; IPR041636; RNase_J_C.
DR NCBIfam; TIGR00649; MG423; 1.
DR PANTHER; PTHR43694; RIBONUCLEASE J; 1.
DR PANTHER; PTHR43694:SF1; RIBONUCLEASE J; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR Pfam; PF07521; RMMBL; 1.
DR Pfam; PF17770; RNase_J_C; 1.
DR SMART; SM00849; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000008320};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 18..211
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|SMART:SM00849"
SQ SEQUENCE 540 AA; 60198 MW; 27A512ED5127A970 CRC64;
MNTDDLLFTP LGGVGQIGMN VNLYHLNGKW IIIDFGAGFA DDNMPGIDMI VADISFIKKN
RKNLLGIVLT HAHEDHIGGI QYLWNDLQCP IYATKFTAAL LQAKLKEYPF RINITEIDIT
KKLNLGPFTL EFINLTHSIP EMNAIALHTE KGIVVHTGDW KLDDNPIIGP VSNTQRLKEL
GDEGVLALVC DSTNIFTKNK SGSESDLEKS IFNIIKNCNQ KVAVSLFASN IARIYTIVNI
ATKLGRKVAI LGKSLIRIIQ AAQDSGYLQD IPEFININQA NKLPNDQVLL LCTGCQGEEL
AATAKLANNS HPFTKLDNGD TIIFSSKIIP GNEKRIYSVF NKFVNMGVNV ITEFMEHVHV
SGHPSKSEVS TMYSLVRPKL SIPVHGEYIH MHEHAKVAKQ CNVEKAIIVH PGDVISLTKK
QKINSVKAGY FGVDGNFLHH PKGNVISMRK KMRDAGIIII TLVLNNKKEL LKEPRIFAPG
VLDHSNSQAI LKKVSSKISS ELYSRKINNI RQYVENTVFN ALKYDIKNKP FIEVQLEYIN
//