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Database: UniProt
Entry: Q2GFN0_EHRCR
LinkDB: Q2GFN0_EHRCR
Original site: Q2GFN0_EHRCR 
ID   Q2GFN0_EHRCR            Unreviewed;       540 AA.
AC   Q2GFN0;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   24-JAN-2024, entry version 90.
DE   SubName: Full=Metallo-beta-lactamase family, beta-CASP subfamily {ECO:0000313|EMBL:ABD45297.1};
GN   OrderedLocusNames=ECH_0966 {ECO:0000313|EMBL:ABD45297.1};
OS   Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC   Anaplasmataceae; Ehrlichia.
OX   NCBI_TaxID=205920 {ECO:0000313|EMBL:ABD45297.1, ECO:0000313|Proteomes:UP000008320};
RN   [1] {ECO:0000313|EMBL:ABD45297.1, ECO:0000313|Proteomes:UP000008320}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC CRL-10679 / Arkansas {ECO:0000313|Proteomes:UP000008320};
RX   PubMed=16482227; DOI=10.1371/journal.pgen.0020021;
RA   Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V.,
RA   Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M.,
RA   Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.,
RA   Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J., Daugherty S.C.,
RA   Davidsen T., Durkin A.S., Gwinn M., Haft D.H., Selengut J.D.,
RA   Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R.,
RA   Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H.;
RT   "Comparative genomics of emerging human ehrlichiosis agents.";
RL   PLoS Genet. 2:208-222(2006).
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DR   EMBL; CP000236; ABD45297.1; -; Genomic_DNA.
DR   RefSeq; WP_006010370.1; NC_007799.1.
DR   AlphaFoldDB; Q2GFN0; -.
DR   STRING; 205920.ECH_0966; -.
DR   KEGG; ech:ECH_0966; -.
DR   eggNOG; COG0595; Bacteria.
DR   HOGENOM; CLU_008727_3_3_5; -.
DR   OMA; KNTCVFE; -.
DR   OrthoDB; 9770211at2; -.
DR   Proteomes; UP000008320; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd07714; RNaseJ_MBL-fold; 1.
DR   Gene3D; 3.10.20.580; -; 1.
DR   Gene3D; 3.40.50.10710; Metallo-hydrolase/oxidoreductase; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR011108; RMMBL.
DR   InterPro; IPR004613; RNase_J.
DR   InterPro; IPR042173; RNase_J_2.
DR   InterPro; IPR041636; RNase_J_C.
DR   NCBIfam; TIGR00649; MG423; 1.
DR   PANTHER; PTHR43694; RIBONUCLEASE J; 1.
DR   PANTHER; PTHR43694:SF1; RIBONUCLEASE J; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   Pfam; PF07521; RMMBL; 1.
DR   Pfam; PF17770; RNase_J_C; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008320};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          18..211
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   540 AA;  60198 MW;  27A512ED5127A970 CRC64;
     MNTDDLLFTP LGGVGQIGMN VNLYHLNGKW IIIDFGAGFA DDNMPGIDMI VADISFIKKN
     RKNLLGIVLT HAHEDHIGGI QYLWNDLQCP IYATKFTAAL LQAKLKEYPF RINITEIDIT
     KKLNLGPFTL EFINLTHSIP EMNAIALHTE KGIVVHTGDW KLDDNPIIGP VSNTQRLKEL
     GDEGVLALVC DSTNIFTKNK SGSESDLEKS IFNIIKNCNQ KVAVSLFASN IARIYTIVNI
     ATKLGRKVAI LGKSLIRIIQ AAQDSGYLQD IPEFININQA NKLPNDQVLL LCTGCQGEEL
     AATAKLANNS HPFTKLDNGD TIIFSSKIIP GNEKRIYSVF NKFVNMGVNV ITEFMEHVHV
     SGHPSKSEVS TMYSLVRPKL SIPVHGEYIH MHEHAKVAKQ CNVEKAIIVH PGDVISLTKK
     QKINSVKAGY FGVDGNFLHH PKGNVISMRK KMRDAGIIII TLVLNNKKEL LKEPRIFAPG
     VLDHSNSQAI LKKVSSKISS ELYSRKINNI RQYVENTVFN ALKYDIKNKP FIEVQLEYIN
//
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