ID Q2GIP0_ANAPZ Unreviewed; 411 AA.
AC Q2GIP0;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE RecName: Full=Citrate synthase {ECO:0000256|ARBA:ARBA00022134, ECO:0000256|PIRNR:PIRNR001369};
GN Name=gltA {ECO:0000313|EMBL:ABD43640.1};
GN OrderedLocusNames=APH_1232 {ECO:0000313|EMBL:ABD43640.1};
OS Anaplasma phagocytophilum (strain HZ).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Anaplasma; phagocytophilum group.
OX NCBI_TaxID=212042 {ECO:0000313|EMBL:ABD43640.1, ECO:0000313|Proteomes:UP000001943};
RN [1] {ECO:0000313|EMBL:ABD43640.1, ECO:0000313|Proteomes:UP000001943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HZ {ECO:0000313|EMBL:ABD43640.1,
RC ECO:0000313|Proteomes:UP000001943};
RX PubMed=16482227; DOI=10.1371/journal.pgen.0020021;
RA Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V.,
RA Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M.,
RA Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.,
RA Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J., Daugherty S.C.,
RA Davidsen T., Durkin A.S., Gwinn M., Haft D.H., Selengut J.D.,
RA Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R.,
RA Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H.;
RT "Comparative genomics of emerging human ehrlichiosis agents.";
RL PLoS Genet. 2:208-222(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308,
CC ECO:0000256|RuleBase:RU003370};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751,
CC ECO:0000256|RuleBase:RU003370}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC ECO:0000256|RuleBase:RU003406}.
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DR EMBL; CP000235; ABD43640.1; -; Genomic_DNA.
DR RefSeq; WP_011451268.1; NC_007797.1.
DR AlphaFoldDB; Q2GIP0; -.
DR STRING; 212042.APH_1232; -.
DR PaxDb; 212042-APH_1232; -.
DR EnsemblBacteria; ABD43640; ABD43640; APH_1232.
DR GeneID; 56369087; -.
DR KEGG; aph:APH_1232; -.
DR PATRIC; fig|212042.8.peg.1325; -.
DR eggNOG; COG0372; Bacteria.
DR HOGENOM; CLU_025068_0_0_5; -.
DR UniPathway; UPA00223; UER00717.
DR Proteomes; UP000001943; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.20.28.60; -; 1.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR InterPro; IPR010953; Citrate_synthase_typ-I.
DR NCBIfam; TIGR01798; cit_synth_I; 1.
DR PANTHER; PTHR42871; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR42871:SF1; CITRATE SYNTHASE; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:ABD43640.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369};
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532,
KW ECO:0000256|RuleBase:RU003370}.
FT ACT_SITE 299
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 356
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 411 AA; 45620 MW; 99BF9D3E7F47A535 CRC64;
MVEKAVLECG DRRISLPVLR GTDGTPVVDI TTLYRENNVL TYDPGFMSTA ACRSEITFID
GNKGTLRYRG IDIENLIGTP NSFSSIVYLL LKGTLPSETE HEEFVRILGA EYDVPEQVMN
VIRSFPRDSH PMAILIASFS ALAANYHASR IDPLTGAIIA IAKVPGIVAS IYRHTANLDF
IQADANLEYT HHFIRMMFGD MDDAHRDIMH KALDAIFIMH ADHEQNASTS TVRMTGSSGA
GLFACLCAGV ATLWGPAHGG ANEAVIKMLA EIGSPENVSS FIDKVKNNKG KSRLMGFGHR
VYKSYDPRAR VLRTICKDVL DSLGRDENLL AVAEELESQA LQDEYFIERK LYPNVDFYSG
IVLRAMGVPV DMYTAFFALA RTSGWASQWY EMIQSDEGKR ISRPRQLYTG K
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