ID   Q2GQ28_CHAGB            Unreviewed;       376 AA.
AC   Q2GQ28;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   RecName: Full=Tyrosinase copper-binding domain-containing protein {ECO:0000259|PROSITE:PS00498};
GN   ORFNames=CHGG_09926 {ECO:0000313|EMBL:EAQ83522.1};
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ83522.1, ECO:0000313|Proteomes:UP000001056};
RN   [1] {ECO:0000313|Proteomes:UP000001056}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC   {ECO:0000313|Proteomes:UP000001056};
RX   PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
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DR   EMBL; CH408035; EAQ83522.1; -; Genomic_DNA.
DR   RefSeq; XP_001227853.1; XM_001227852.1.
DR   AlphaFoldDB; Q2GQ28; -.
DR   STRING; 306901.Q2GQ28; -.
DR   GeneID; 4396477; -.
DR   VEuPathDB; FungiDB:CHGG_09926; -.
DR   eggNOG; ENOG502RM4B; Eukaryota.
DR   HOGENOM; CLU_035914_0_1_1; -.
DR   InParanoid; Q2GQ28; -.
DR   OrthoDB; 4070889at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF141; N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR   PROSITE; PS00498; TYROSINASE_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001056};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..376
FT                   /note="Tyrosinase copper-binding domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004208877"
FT   DOMAIN          297..308
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS00498"
SQ   SEQUENCE   376 AA;  40649 MW;  838C3F29E1D38D4A CRC64;
     MKLSASIALA AAMGASATFN LPAFEQLAID SGLALSGLNG LALLQSATKY GGSCNIGNVK
     IRREWRTLSK AQRKSYIKAV QCLQKSPSLL PAGVSAGSKT LFDDFVYVHL QSTPFIHFTG
     NFLIWHRNYI HEYEEEGSMP VVTRWSFDAS APHLSPIFDE SDTSMSGDGE FIPGPDLSLE
     IPGNAEPVVL KKGTGGGCVK TGPFADMTVR LGPITQPDPT ADNPRCLKRD LNADAGSRFS
     SFRNTTDLII NSPNIEIFRT TMEADPNYIP NSLGVHGGGH FMISGDPGSD AFISSGDPAF
     YLHHAQIDRV YWIWQMLDFQ NRQGVFGTNT LLNAPPSANT TVEDTVDVGH IGAPIKIKNL
     MSTTGQNGSP LCYIYL
//