ID Q2GTB1_CHAGB Unreviewed; 2379 AA.
AC Q2GTB1;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EAQ84779.1};
GN ORFNames=CHGG_08793 {ECO:0000313|EMBL:EAQ84779.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ84779.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004721}.
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DR EMBL; CH408034; EAQ84779.1; -; Genomic_DNA.
DR RefSeq; XP_001226720.1; XM_001226719.1.
DR STRING; 306901.Q2GTB1; -.
DR GeneID; 4395430; -.
DR VEuPathDB; FungiDB:CHGG_08793; -.
DR eggNOG; KOG1202; Eukaryota.
DR HOGENOM; CLU_000022_6_3_1; -.
DR InParanoid; Q2GTB1; -.
DR OMA; KDNIGHT; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR032088; SAT.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF21; NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED; 1.
DR Pfam; PF18558; HTH_51; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR Pfam; PF16073; SAT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001056};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 389..779
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1549..1626
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 340..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1525..1549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..840
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2379 AA; 255293 MW; 68950B6ED632D566 CRC64;
MDTNGDSGGF TEGTLLLFGP QMTRLTGSHL TDLRTTILGN PELDFLVKAV RALPSQWTTT
VQTACPGLGA GDLGASQTQQ LQQLAHFFET GELPASEPPN NVVLAPLTVV SQVAEYLRLG
RRGPVQGFCI GFLAATAVAS SRNREELAEL VGVAIKLAAC VGAVIDCEEH EQLRQPGSLG
LNAAHSVRWT SSAEKVHLEK TLASFPEVYM SCVTDIDRVT ITAPESRLAE LCRRLADGGM
VAQPVGLYGR YHEASQNREV LVRELKALCQ QNVAFQLPTA ENLVLPLRST AAAAGQIINQ
GALSDIAIDS ILTEKCDWFE TVRAAVAAFG DRSPINITPI GGPGAVPRSL TPGKAGEKSA
LSRDSVLVNG TSRSGEPIPR PVSEMPVRGD AIAVIGMACR YPQAPSLDEF WSLIISGRNA
VGPVPQNRFR AEELWREPKG PFWGNFVQDP DAFDHRFFQV SAREAASMDP QQRLILQVAY
EAIESAGYAS GQGPQRVGCY MGVGSVDYEA NVASDNATAF SATGTLRAFI SGKVSHYFGW
TGPSVTFDTA CSSSAVAIHH ACKALQTKEC PVAIAGGVNL ITSPSLYQNL AAASFLSPTG
ASRAFDAQGD GYCRGEGAGV LVLKPLAQAL ADGDAILGTI LGTAVNQGSN CTPITVPDSA
AQSELYAQAL AGGGVAPTEV TYVEAHGTGT PVGDPIECAS IRSAFGGAHR QQELTIGSVK
DVIGHTEAAS GVAGCIKTLL MMQHGVIPKQ PNFTRLNTKI PPLEARQACH RNAAAPLGDC
QPSKAHGRSS TTTRRRQQRG HPPPGTPSRA ISGTAPPKQR PPDTIEPPRP PAPPPKPKPS
LQDITFHLAR RLNPSFPHLA TWTTTSLPAL GQDLAALASG TRPITTTTPS SSSPSRPTDP
LPIILTFGGQ SGLTAHLSPA LVSHSPSLHT HLSHCDTALR TLGLLPLFPR IFDAAPYEPD
NLVGLHAALF SVHHAYHSRL ADPSGWPPRR GRVHCMAAAD HPCRDVLSRV PKRLGRRPGE
TIVDAANLVT AHTRDTVHFA DAVERIVRRH PGGCVWLEAG SASPVVAMAR RALPTATTAA
SHVFLPLDLG RGSSSPWSGL ARAVTSLWAA RSTATFWPFH GPQYPWVDLP PYQFAKSKHW
IDFEAPGRRD SVEKLAPEVG PAELVRLVQH HKAGGEALFA VDASHDDFIL CVSGHAVLGQ
SLCPASMYFE LVIRAMKAFQ SSPATGVTQV PRLENLRIMS PLALKPDGRL YLSLIPAAGK
GDGSSTWNFS LFSSPLTGPT LPSPSSPRTT HALGTAAFIE ADSTAVASRF RFLGRLMGSS
RYEQIALSPG ANRLSGDIIY RVFGRIVNYA PHYQGVRNVV AGNGEVVGDV VMPNSPKPEA
RQSPLGVSNP LAIDNFLQVA GIHVNCMTGD GREDDVFVCT GIGEVLWSDT FMRGPTGGDD
GKPSSAGSWR VYSNVDAKRK NTVVNDILVL DPVSGDVVLA ILNAEFTRVS MSSLYRALSK
LNGASGSLPT PPPEREPVDQ VKVTTYPQDL PNGTSPQATP SQGSVTGHTS GPRLIDALRN
LLSEVLGTEL AEIQPASELA DLGVDSLMIT ELAGEIKKHF SVDISLSDLQ EMTDVQSLSH
RLEPLVSGYE STSAPTPAGS DTPPPVINGV VRNEEPSSSS EGAREEVGVA DAASEWLASN
RNTYDTVVQE SGLQHFREDV YPHQAQLVVA YVVEAFARLG CHLRTLQPGD SLPNIKHLPR
HEKVMAQIYR ILEDAGLLDV DGAGTRRRTS RPTPQATASD LHDRILQQFP QHFSEHSLLH
TTGSRLADCL SGDADPISLL FGNAEARRLL GDVYTNAPMF KAGTLFLARF LAQTLTQHLA
DHSGRGEIRI LELGAGTGGT TSHLLEHLAA SGLGHKLRYT FTDLSSSLVA AAKKKFAQYP
FMEYAVLDIE QNPPAHLLGR FDMVISTNCI HATRDLTRSC THIRRTLREG GLLCLVELTQ
NLFWFDLVFG LLEGWWLFND GRSHALASET LWQKDLLASG FDWVDWSDGA SAEASILRLI
VASTSPRPHP LPSPPPQIPE GPGVADIDTA ATTPLETQET VIFKHAGPLA LQADIYYPPT
PDPPGSKPRP VETTLLEGPM TDVRDALAWA RRTLPHAEAS PRRRRPDVRV DGTRVVAVGW
STGGMLALSL GWTAAGVGVQ APEAVLGFYC PSDYEDGWWG RVNLPFGEEE EDGEEGEFDV
WEGVEEAPIV EYNPPVAAQA AGGWMARRDA RSRIALHMNW RAQTVPVLVH GLRKGEGKGT
PVLPWPEPEQ VVAISPLAQV QLGNYRTPTF LVHPVDDDLI PWQQAQRTVE ELRARGVSAE
VRIVDKAVHL FDLYRRYDRH AGAIAAISDG YEFLARSVR
//
