ID Q2GV60_CHAGB Unreviewed; 1013 AA.
AC Q2GV60;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=O-methyltransferase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=CHGG_08144 {ECO:0000313|EMBL:EAQ86891.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ86891.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- SIMILARITY: Belongs to the flavin-dependent halogenase family.
CC {ECO:0000256|ARBA:ARBA00005706}.
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DR EMBL; CH408033; EAQ86891.1; -; Genomic_DNA.
DR RefSeq; XP_001225800.1; XM_001225799.1.
DR AlphaFoldDB; Q2GV60; -.
DR GeneID; 4394158; -.
DR VEuPathDB; FungiDB:CHGG_08144; -.
DR eggNOG; KOG3178; Eukaryota.
DR HOGENOM; CLU_305659_0_0_1; -.
DR InParanoid; Q2GV60; -.
DR OMA; YEKWDAH; -.
DR OrthoDB; 1067404at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR002938; FAD-bd.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43747:SF1; FAD-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR Pfam; PF01494; FAD_binding_3; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001056};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 7..360
FT /note="FAD-binding"
FT /evidence="ECO:0000259|Pfam:PF01494"
FT DOMAIN 852..990
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT REGION 558..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1013 AA; 108613 MW; 521AACA7D0E4662D CRC64;
MSIPQSCTVL VVGGGPAGSF ASAALAREGI DVVMLEADKH PRYHIGESML PSMRHFLEFI
DCYEQFNAHG FIKKNGAAFR LNKTQPEAFT DFIAAGGPNG HAWNVVRSEA DELLFNHAAS
CGVRAFQTTK VDAVQFEESD GETAGPGRPV SASWKRKDGT TGTIAFKYMV DASGRYGLLS
TKYLKNRKFN QSLKNIANWA YWKGGGIYAE GTHKAGSPFF EALQDASGWC WFIPLHDGTH
SIGIVQNQEM ATEKKRAAGS PSTKEFYTQS LDLAPGIKAL LSKAEVVSDV KSASDWSYSA
DTYAFPYARI AGDAGAFIDP FFSSGVHLAV LGGVSAAVTI AASIRGDCDE KAAASWHSKK
TAESYTRFFL VVSSALKQIR MQEDPVIQDL DEEGFQRAFD LFRPVIQGTV DAHHNGKLTQ
SEISNTVEFC FKAFTHVTPE QKDAVVNKLR KLSANAEAGD EETIDNALGE IEKSLTPDEL
QVLNILRGRR MIREDGYNMD SFTLDTIDGL APRMERGKLG LAKSQAARLS KAHLYSADYL
EGKRPGVRVV QPAKSMNGAN GHSNGEANGH TNAANGTNGV NGANGTNGHT KEHANGHENG
SGMNGAAKAT FNAANGAGLF ASPINGQAAQ LDDVGRHALM NTLHEAAENL ETPFDLVMRL
GNSARLLTYI RVAHTLNLFA TLSNASPTPV PLTTLTSTGP APGAAPTFIR RVLVFLAANR
LIGEAGPDLF VATKATHSLA LPGVAGGATF YQGVIAPMTQ YLPESPLAKC GYVQRAGEPA
VFDSWSAGVE GGGRGLWPYL KGRPEMLGAF QELMALDRGG GDWVGCVDFE GVDSPSLVMG
GEGGGGSERV VFVDVGGNVG HQARRLVERH PRLAGRVVVQ DLPETVAAAP AAKGVAFLAH
DFFEPQPVRG ARYYYLRSVL HNWGDAQAVE ILKNVAAAMV EDSRVLIDEM VVPDKSADVL
VAGQDLNMML LFGGMERRTD DWAALLDRVG LKIVEVKMYG PVTKNSIIVA MLK
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