ID YTM1_CHAGB Reviewed; 484 AA.
AC Q2GXT0;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE RecName: Full=Ribosome biogenesis protein YTM1 {ECO:0000255|HAMAP-Rule:MF_03029};
GN Name=YTM1 {ECO:0000255|HAMAP-Rule:MF_03029}; ORFNames=CHGG_07224;
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL
CC domain) with MDN1 (via VWFA/MIDAS domain). {ECO:0000255|HAMAP-
CC Rule:MF_03029}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03029}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03029}.
CC -!- SIMILARITY: Belongs to the WD repeat WDR12/YTM1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03029}.
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DR EMBL; CH408033; EAQ85971.1; -; Genomic_DNA.
DR RefSeq; XP_001224880.1; XM_001224879.1.
DR AlphaFoldDB; Q2GXT0; -.
DR SMR; Q2GXT0; -.
DR STRING; 306901.Q2GXT0; -.
DR GeneID; 4393224; -.
DR VEuPathDB; FungiDB:CHGG_07224; -.
DR eggNOG; KOG0313; Eukaryota.
DR HOGENOM; CLU_000288_57_0_1; -.
DR InParanoid; Q2GXT0; -.
DR OMA; YMAPQPE; -.
DR OrthoDB; 36593at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR HAMAP; MF_03029; WDR12; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR012972; NLE.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR028599; WDR12/Ytm1.
DR PANTHER; PTHR19855:SF11; RIBOSOME BIOGENESIS PROTEIN WDR12; 1.
DR PANTHER; PTHR19855; WD40 REPEAT PROTEIN 12, 37; 1.
DR Pfam; PF08154; NLE; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing;
KW WD repeat.
FT CHAIN 1..484
FT /note="Ribosome biogenesis protein YTM1"
FT /id="PRO_0000369583"
FT REPEAT 122..161
FT /note="WD 1"
FT REPEAT 168..206
FT /note="WD 2"
FT REPEAT 216..255
FT /note="WD 3"
FT REPEAT 288..328
FT /note="WD 4"
FT REPEAT 330..373
FT /note="WD 5"
FT REPEAT 379..419
FT /note="WD 6"
FT REPEAT 448..484
FT /note="WD 7"
FT REGION 13..95
FT /note="Ubiquitin-like (UBL) domain"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03029"
SQ SEQUENCE 484 AA; 51426 MW; A24600AD31B7BC0E CRC64;
MDEPMVDASG AQVKVTFTTT EADLQLPESK RQLLVPADIR RYGLSRVLNS ESMLDTGSIP
FDFLVNGSFL RTSLEDYLTN NGLSLESNLT LQYVRSLIPP VYEASFEHDD WVSAVDVLSA
SSPSGRWSGD NFQRGQDRIL SASFDGLLRI WNASGQVIAT SPSGSHGGHT ASIKAAKFLT
NSQLASAGMD RTVRVWKYTE SDHFSGDLKP TLELYGHTGS IDSLEVDGAS KRILTASADG
SIGFWSTSKA SAPEADSSLL PNAHTSKRRK VTTSVTAAQR GPLSLMPIHS APASAAVFDP
RDRTVAYSAS QDHTLRTIDL TTSTVVTTHS TSHPLLSLCA LPRGNSASPL LAAGTAARHI
TLVDPRASAA TTSVMTLRGH ANKPVGLCAS PRNEYALVSG AHDGTCRVWD LRSVRPATQE
EGGLGSVSEA VYVIEREGAK GGKKTVAGEG CKVFGVVWDA ELGIVSGAED KRVQINAGRD
VVAE
//
