ID   Q2GZJ4_CHAGB            Unreviewed;       386 AA.
AC   Q2GZJ4;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   RecName: Full=Tyrosinase copper-binding domain-containing protein {ECO:0000259|Pfam:PF00264};
GN   ORFNames=CHGG_05052 {ECO:0000313|EMBL:EAQ88433.1};
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ88433.1, ECO:0000313|Proteomes:UP000001056};
RN   [1] {ECO:0000313|Proteomes:UP000001056}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC   {ECO:0000313|Proteomes:UP000001056};
RX   PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
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DR   EMBL; CH408032; EAQ88433.1; -; Genomic_DNA.
DR   RefSeq; XP_001224266.1; XM_001224265.1.
DR   AlphaFoldDB; Q2GZJ4; -.
DR   GeneID; 4392903; -.
DR   VEuPathDB; FungiDB:CHGG_05052; -.
DR   eggNOG; ENOG502RM4B; Eukaryota.
DR   HOGENOM; CLU_035914_0_1_1; -.
DR   InParanoid; Q2GZJ4; -.
DR   OMA; LKSKCQY; -.
DR   OrthoDB; 4070889at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR   InterPro; IPR008922; Di-copper_centre_dom_sf.
DR   InterPro; IPR002227; Tyrosinase_Cu-bd.
DR   PANTHER; PTHR11474:SF141; N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED; 1.
DR   PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR   Pfam; PF00264; Tyrosinase; 1.
DR   PRINTS; PR00092; TYROSINASE.
DR   SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Monooxygenase {ECO:0000256|ARBA:ARBA00023033};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023033};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001056};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..386
FT                   /note="Tyrosinase copper-binding domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004209146"
FT   DOMAIN          105..326
FT                   /note="Tyrosinase copper-binding"
FT                   /evidence="ECO:0000259|Pfam:PF00264"
SQ   SEQUENCE   386 AA;  42682 MW;  05119BBF27B14CA2 CRC64;
     MMKSIVLLAS ALLAGSAVSA PTAEIPSFTQ AEMDSGKAIR ELGRIAYENA MARAAKATTG
     CTKENVRIRK EWRNMTLDDR QGYQQAVQCL MEKPARHKGL DGVRTAWDDY GALHYYQTPY
     VHNSATFLLW HRHYNWVLEQ DLRDLCGYNG VFPYWEWGLD CGSVGSMDKS PVFDGSEYSL
     GGNGEFIEGH RAAIGGAKPG SGGGCLTSGP FSNYTVNLGP VGSRNPLAYN PRCFKRDLNT
     DICNRWATLR NTTEPILNGK DIAVFQALVQ GDGRWPEAAR LGIAVHGGGH YAISGDPGSD
     FYFSSLEPGF YLHHGNIDRM HFIWQNLDWE NRQTISGTNT MFNRPATPEA VLGDNMGFEP
     INRNVTIGQT MDTVGGTPLC YVYEPW
//