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Database: UniProt
Entry: Q2GZU7
LinkDB: Q2GZU7
Original site: Q2GZU7 
ID   DBP7_CHAGB              Reviewed;         806 AA.
AC   Q2GZU7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   18-SEP-2019, entry version 70.
DE   RecName: Full=ATP-dependent RNA helicase DBP7;
DE            EC=3.6.4.13;
GN   Name=DBP7; ORFNames=CHGG_04949;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC
OS   6347 / NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Chaetomiaceae;
OC   Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium
RT   globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of
CC       60S ribosomal subunits and is required for the normal formation of
CC       25S and 5.8S rRNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX31/DBP7
CC       subfamily. {ECO:0000305}.
DR   EMBL; CH408032; EAQ88330.1; -; Genomic_DNA.
DR   RefSeq; XP_001224163.1; XM_001224162.1.
DR   SMR; Q2GZU7; -.
DR   STRING; 38033.XP_001224163.1; -.
DR   PRIDE; Q2GZU7; -.
DR   EnsemblFungi; EAQ88330; EAQ88330; CHGG_04949.
DR   GeneID; 4392137; -.
DR   eggNOG; KOG0348; Eukaryota.
DR   eggNOG; ENOG410XNT7; LUCA.
DR   InParanoid; Q2GZU7; -.
DR   OrthoDB; 973872at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR025313; DUF4217.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF13959; DUF4217; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01178; DUF4217; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    806       ATP-dependent RNA helicase DBP7.
FT                                /FTId=PRO_0000256024.
FT   DOMAIN      174    380       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      413    611       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     187    194       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       141    170       Q motif.
FT   MOTIF       309    312       DEAD box.
FT   COMPBIAS    729    779       Gly-rich.
SQ   SEQUENCE   806 AA;  87023 MW;  BE971C4BC071D7C0 CRC64;
     MADDGMLLNF EIGDAPLKSQ VKFKGGRWRD RLKAQRSAKQ SHEDGPSSTP PRNRTTVGGY
     DAGRLGKRPR TEDGESHRYA KVPRTSDAAP KAPSHAMKTG QISSSLFTSN PSAVTDFDQP
     PAEEEAEPAK ASNAPLSEEA ENFHSLGVSR RVAQHLATKL EMKAPTAIQK NTVPQLINGD
     SDAFLQAETG SGKTLAYLLP IVHRIMSLSL NEDGTPKDTK VHRNSGLFAI IMAPTRELCK
     QISVVLEKVL RCAPWLVCTT VIGGESKKSE KARIRKGVNI LIATPGRLAD HLDNTKVLNV
     GTVRWLVLDE GDRMMEMGFE DDIKTIVGKI RADKLEKVNA EGVVLDGVLP SRRVTVLCSA
     TMKMNVQKLG EISLEDAIHI MAAKSESDGD ADAVFAAPSQ LKQSCIVTPA KLRLVTLIAL
     LKSTFARRGS VMKAIIFISC ADSVDFHYQL LKDTKAVEPP TPDSSSTKDR NPHTDTTVAR
     AAYITSPANP KVMLHKLHGS LAQPVRSATL NAFSACKDPA VLITTDISSR GLDVPAVDLV
     IEYDPAFAVP DHVHRIGRTA RAGRAGKAVL FLLPGCEEGY TTILNSSTPI APQLYESILQ
     KGLASVVNLP STHTTSETDK QTWSTRAEAL QLHLEQRLLA NPAGADDDAD DNPNPFRGNK
     GNHNNNTKPK SKQYKPKIDN PLLDAARQAF RSHIRAYATH VREERVYFDI LQLHLGHLAK
     AFALREPPGG IGGGVARRTH TAANKAAAER KSKVSGGGGG GGRVGFGRGA ADDDGDGVGA
     VDEDAARRMR EKMRMVMNAS SEFNIG
//
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