ID Q2H3E6_CHAGB Unreviewed; 1058 AA.
AC Q2H3E6;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=CHGG_06819 {ECO:0000313|EMBL:EAQ90200.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ90200.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
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DR EMBL; CH408031; EAQ90200.1; -; Genomic_DNA.
DR RefSeq; XP_001222914.1; XM_001222913.1.
DR AlphaFoldDB; Q2H3E6; -.
DR GeneID; 4391328; -.
DR VEuPathDB; FungiDB:CHGG_06819; -.
DR eggNOG; KOG0987; Eukaryota.
DR HOGENOM; CLU_289670_0_0_1; -.
DR InParanoid; Q2H3E6; -.
DR OrthoDB; 1953012at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR046797; PDDEXK_12.
DR InterPro; IPR049163; Pif1-like_2B_dom.
DR PANTHER; PTHR47642; ATP-DEPENDENT DNA HELICASE; 1.
DR Pfam; PF20516; PDDEXK_12; 1.
DR Pfam; PF05970; PIF1; 1.
DR Pfam; PF21530; Pif1_2B_dom; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000001056}.
FT DOMAIN 241..478
FT /note="PD-(D/E)XK nuclease-like"
FT /evidence="ECO:0000259|Pfam:PF20516"
FT DOMAIN 908..940
FT /note="DNA helicase Pif1-like 2B"
FT /evidence="ECO:0000259|Pfam:PF21530"
FT REGION 13..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1058 AA; 117735 MW; 415CA142E39F66A7 CRC64;
MSNNPAIYHW LSSLPDCHEG HCGETTSVKH KPKRTRGEMT TPPSSTARTG SLSPGPKKRK
IDDSRPDSHG PDPDPDATPR SGRSQRPSVT TLSMRTAFPP PSDSSAASAV SSRQDRSSRS
SRRSASPVKN ITGLQRLDKP VLFDSLDDNA GLIQLPEDVR ELYYNIFAAT KYQSGIYPAE
IRTEIEALYT GHPPPDSVYR KPGGGNDQDG IGQEEEHFFD YLPVSALFSG TAEGATSQAR
IAHAEFYKVR AIKDRARECL ALRRAEAAWN TKVHEPLLEL ALSRRHTSVI CENATSARIL
PCFLPCLITG EVAEGKMVDF VLAPNLGSES ELDIAIQNKL VELAKQMRSS GLISARLCVN
QTDYPPLMRS PAAVTMETKV AGASLEEGRL QLGVWIAAWH RRMEMLGVGG GKSGPQLPTL
PLILTHDHEW SLYFAVDRLD KIEIFGPMQI GMTDNLPNIY QLLTVLGFLG AWIDTTFRTW
VINAFQQWLN IEEDGTGGKR LTARLLYYYP RYKPVRSHQQ YSDFCRVKLL LNHPHRQSEQ
LLEVDLGLDN KGLGLPLPEE DEFERGEDAG DITLEDWQEV ARLVPDLQLP HNLPEERVPR
VKVPGRDMET LQQRQVYDTV MRHYRAKNEN RQPPPLRLQI DGGGGTGKSY MVKVISSHLQ
AEAASYGRVS PIVRAAPTGV ASNQIGGQTL HSMLRLPVDG NYRSLSETPT TLNALQRRFR
GIHYLVIDEK SMLGLKTLAW IDQPLREVFP ENRDEFFGGL SVILIGDFFQ LPRVLNKPLY
STRDDLKGIE IVGRNAYLSF DKSVFLTTIQ RQQGEDQAPF RRALEELRKA DVSVPSWELL
ASRCSVKLSP EEVDSFADTL RIYPTKTQVV EYNHQHMLGL DSPAIQVEAK HEGVGAEKVE
SSNAGNLAKR LPLCVGCRVM LTRNLWADVG LVNGAQGTVY DISWKEGTDD FMVGANSCSR
EQFPLLVSYA ITVHKSQGIT LDKVVCDISA PEFASGLSYV AVSRVKTLRG LMFERPFERS
RIYRETPSPA MGLKLSDHAT RQLQALDAVA GEVPSESN
//
