ID Q2H5U1_CHAGB Unreviewed; 313 AA.
AC Q2H5U1;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Transcriptional activator HAP2 {ECO:0000256|RuleBase:RU367155};
GN ORFNames=CHGG_05974 {ECO:0000313|EMBL:EAQ89355.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ89355.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- FUNCTION: Component of the sequence-specific heterotrimeric
CC transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3'
CC box motif found in the promoters of its target genes.
CC {ECO:0000256|RuleBase:RU367155}.
CC -!- SUBUNIT: Heterotrimer. {ECO:0000256|RuleBase:RU367155}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367155}.
CC -!- SIMILARITY: Belongs to the NFYA/HAP2 subunit family.
CC {ECO:0000256|RuleBase:RU367155}.
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DR EMBL; CH408031; EAQ89355.1; -; Genomic_DNA.
DR RefSeq; XP_001222069.1; XM_001222068.1.
DR AlphaFoldDB; Q2H5U1; -.
DR STRING; 306901.Q2H5U1; -.
DR GeneID; 4391382; -.
DR VEuPathDB; FungiDB:CHGG_05974; -.
DR eggNOG; KOG1561; Eukaryota.
DR HOGENOM; CLU_045001_1_0_1; -.
DR InParanoid; Q2H5U1; -.
DR OMA; HQDSMAG; -.
DR OrthoDB; 5490901at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.250.2430; -; 1.
DR InterPro; IPR001289; NFYA.
DR PANTHER; PTHR12632:SF6; NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT ALPHA; 1.
DR PANTHER; PTHR12632; TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED; 1.
DR Pfam; PF02045; CBFB_NFYA; 1.
DR PRINTS; PR00616; CCAATSUBUNTB.
DR SMART; SM00521; CBF; 1.
DR PROSITE; PS51152; NFYA_HAP2_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU367155};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367155};
KW Reference proteome {ECO:0000313|Proteomes:UP000001056};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU367155};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU367155}.
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 96..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 220..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 313 AA; 33694 MW; 86E6D5FAFC6F6D66 CRC64;
MMEYAQYQQQ PQSAHSQPHI QTGYPTSAGG NSITSPSTQH LSQTSPILPS QQHQPSPTQQ
HGMYQPGYGV AQQNMHYGLQ GMQAAAMAAT AAAAGSSYPY MPSDPSLQQS PRMSGVGAKK
DARAGPRSPQ QMANIPQQRR LSQVASPGVP NAPTMLNHGG PRTAVPPPMS AAQQMPPPQS
PEMASGAVEE SPLYVNAKQF HRILKRRVAR QRLEEALRLT SKGRKPYLHE SRHNHAMRRP
RGPGGRFLTA EEVAQMEKDK TGGGAGEKTE EQPASTKTAA GGTKRKSEGG ANGPPKKTKR
ARSTPEDDED EDE
//
