ID   Q2H876_CHAGB            Unreviewed;      1547 AA.
AC   Q2H876;
DT   21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   21-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 75.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   ORFNames=CHGG_03578 {ECO:0000313|EMBL:EAQ91643.1};
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ91643.1, ECO:0000313|Proteomes:UP000001056};
RN   [1] {ECO:0000313|Proteomes:UP000001056}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC   {ECO:0000313|Proteomes:UP000001056};
RX   PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
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DR   EMBL; CH408030; EAQ91643.1; -; Genomic_DNA.
DR   RefSeq; XP_001230094.1; XM_001230093.1.
DR   GeneID; 4389105; -.
DR   VEuPathDB; FungiDB:CHGG_03578; -.
DR   eggNOG; KOG1075; Eukaryota.
DR   HOGENOM; CLU_000680_23_2_1; -.
DR   InParanoid; Q2H876; -.
DR   OrthoDB; 1368934at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR036875; Znf_CCHC_sf.
DR   PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR   PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001056}.
FT   DOMAIN          970..1221
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          83..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          222..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1368..1395
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1528..1547
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          190..221
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        96..110
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1368..1382
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1547 AA;  172585 MW;  49DCF1BA321081A6 CRC64;
     MEMQNLKMGI SVRHVTRHVT CGPTVQCRDS TPPSRWRRLN FETLIVNGKF LQGGTFCESR
     AALPRDCKMA AEAQPQIVVE VADQPPSPRR PSRASKPSAK AREAMESLED VATTSRRAAS
     ETTRAVTTRG ARASGILYGA NSRIETGKSG IQMLLEAINE QRDEMYRMIT EQRNTIGELR
     EVICKQHDAI QELHRQLADT RTQLSEELRQ ARDQIDTLQR NPVAMASSQP SARGSYAEVA
     RTPPSSQPSG VRTLSSRNTT PSSFTDTLFC TIDTSRVEEK EKGNVQVADI RKAIETEARA
     QESMGDWRCA AVVKEARNPD RVRVICRDEG EVQLVKEAAE KISVPGVRVL RDQLYPVRVD
     NANRTAVLDA DGNILPGAAE ALGTENDVNI AKIAWLSRKD TSKAYGSMVV YVTKGSEARR
     LLDGRYFHLA GESAYTTVFA PREGPIQCYR CQEIGHKAFA CKKPQRCGRC AEQGHHHKTC
     QSVVLKCVLC RGPHESFSKN CRQSLLNDEG LKDFAVLAIS EPYARLIEGS VTTVPMSHYN
     WTKLIPTTRR EATWPIRSML WVRSDIEVEQ IPVPSADLTA ARIRLPDRAV LMVSVYVEGG
     SDEALEDAMR EIDLMIKRFR NGTGTRTDII LAGDFNRHDQ LWGGDDVSPR RQGEGDRIIN
     LMDEHSLCSL LPRGTKTWQS GDIESTIDLV LASAELADQL LRCTIHPCDH GSDHRAIETA
     FDTTVEDRPS ETRFLFKNAP WAEIRTRVAA NLERIPWDGN VQQQTDRLMA VVTEAVYALT
     PKAKPSPYAK RWWTTDLTRL RQTYTFWRNQ ARSRRRIGQT APEIEQRARM AAKEYHDAIR
     RQKSSHWNDF LADDANIWQA TKYLQTGSGT MGDKIPPLVR PDGSITEGKA EQAQELLTAF
     FPPLPARIED EGQRPQRAPV HMPDLTMEEI EQKVLSAKPW KAPGEDGLPA MVWRQLWPVV
     KDRVLHLFRT SLRDGDIPSQ WRNAKIIPLK KPGKSEYTLA KSWRPISLLS TLGKILEAVI
     AERLSHAVET CGLLPANHFG ARKRRSTEQA LLLLQEHIYK AWRARKVLSL ISFDVKGAYN
     GVFKDRLLQR LRARGIPESL VKWIDAFCSK RTATIAVNGF TSGRDFQNNR SSVKGRSVQT
     ELSAKILGVV MDRELCYKQH IARTAAKGLA AALALKRLKM LSPRTARQLF VATVAPVMDY
     AANVWMHACG EKALSWLNRA QKIGALAITG AFRTAATAVV EAEASIYPVR ERHAQAAASL
     WINIHTLPGT HPLAMKKVRT TVRFVSPLQK IARVAEGVRV DRMETIQEYA VPPWVPRLRP
     TLEADRGKAA EMVNKISGIV IATSSSAAPT KRELGQLSVD TSEIDFALGS DAQGSSPESV
     EARTHTRLPK CPKPKSTAMR LAMERQRATR VLPVGVGKFS KTMDAALPGK HTRDLYDKLK
     RREACVLAQL RTGMARLNGF LSRIGAVESD LCACGQARES VEHFLFPMRE MDSSEGRHAA
     MHSGKTRKPL VLSGRESAIR YKASVTRYEG SPGDDQIRNG NRKAGAE
//