ID Q2H8A1_CHAGB Unreviewed; 251 AA.
AC Q2H8A1;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN ORFNames=CHGG_03553 {ECO:0000313|EMBL:EAQ91618.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ91618.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Dihydroflavonol-4-reductase subfamily.
CC {ECO:0000256|ARBA:ARBA00023445}.
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DR EMBL; CH408030; EAQ91618.1; -; Genomic_DNA.
DR RefSeq; XP_001230069.1; XM_001230068.1.
DR AlphaFoldDB; Q2H8A1; -.
DR STRING; 306901.Q2H8A1; -.
DR GeneID; 4388381; -.
DR VEuPathDB; FungiDB:CHGG_03553; -.
DR eggNOG; KOG1502; Eukaryota.
DR HOGENOM; CLU_007383_9_4_1; -.
DR InParanoid; Q2H8A1; -.
DR OMA; REMIDTF; -.
DR OrthoDB; 552946at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF562; ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360); 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001056}.
FT DOMAIN 15..147
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 251 AA; 26719 MW; 18025A8B3B440885 CRC64;
MSSLTTSIPP GSWVLVTGAS GFLASHISLQ LLKRGFKVRG TVRDPAQSTW LLEGCFKPYA
DTDAIELVSV PDMGVDGAYD KAIKGVSAII HTAYVTNIVP DPNAVITPMI TGIRSIMNAA
IREPSVKVAV FTSSAVSASP LTDGVDNGIV GRDSWNNAVL EAAWAPPPYG LSHAVANYPA
SKLAAEKEVW KFAESNDLHF IVNVVAPAGL IGEPLNKKHI EGQASWVTHA YKGNKPVMDL
FQACKNYSTS Q
//