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Database: UniProt
Entry: Q2H8D5
LinkDB: Q2H8D5
Original site: Q2H8D5 
ID   SET9_CHAGB              Reviewed;         734 AA.
AC   Q2H8D5;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   10-APR-2019, entry version 61.
DE   RecName: Full=Histone-lysine N-methyltransferase SET9;
DE            EC=2.1.1.43;
DE   AltName: Full=SET domain protein 9;
GN   Name=SET9; ORFNames=CHGG_03519;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC
OS   6347 / NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Chaetomiaceae;
OC   Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium
RT   globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Histone methyltransferase that specifically methylates
CC       'Lys-20' of histone H4. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00900};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. Suvar4-20 subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00900}.
DR   EMBL; CH408030; EAQ91584.1; -; Genomic_DNA.
DR   RefSeq; XP_001230035.1; XM_001230034.1.
DR   ProteinModelPortal; Q2H8D5; -.
DR   SMR; Q2H8D5; -.
DR   STRING; 38033.XP_001230035.1; -.
DR   PRIDE; Q2H8D5; -.
DR   EnsemblFungi; EAQ91584; EAQ91584; CHGG_03519.
DR   GeneID; 4388557; -.
DR   eggNOG; KOG2589; Eukaryota.
DR   eggNOG; ENOG410XPH8; LUCA.
DR   InParanoid; Q2H8D5; -.
DR   OrthoDB; 953612at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:InterPro.
DR   InterPro; IPR025783; Hist-Lys_N-MeTrfase_SET9.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   PROSITE; PS51567; SAM_MT43_SUVAR420_1; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosome; Complete proteome; Methyltransferase;
KW   Nucleus; Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    734       Histone-lysine N-methyltransferase SET9.
FT                                /FTId=PRO_0000281801.
FT   DOMAIN      116    230       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
SQ   SEQUENCE   734 AA;  81046 MW;  97B199EF0625EDD9 CRC64;
     MPRAPTSAIK KQPLTFAQLA AYDDILTDAL IDHVYYWTAI PKNRPLYHPS RGIREEEITK
     IIQTHLIVDP DLAIAEEKLL ATDGLRKFHN SLRTDKEKED FKAHLRRYIS IYLPDCPFEV
     NATNRFTIDS YEASITARRP IRRNEAIKYL AGTQVTVTPE EEAQLALRKK DFSLVVSSRS
     KLTSLFMGPA RFANHDCAAN ARLVTRGSAG IEIFACRDIG LGEEITVTYS ESYFGENNCD
     CLCQTCEDNV ANGWKPKDGT VPVHRSIEES VLGDDQGYSL RRRRRERSVS VAGSRTSSVT
     PDIRPRIFKT AKNRAMASDR ASTTDSDGID VVAMAVAAPK RNFDTTALSS PPLTPAKRQK
     PNHYDVVPLP LGLDVSRDSS ASGPVDSLIA TEDEKSTATQ ATTPEFEEPK PPSMREKPLL
     SPEMSPMKEG ATPVGALNGE RDEPTETGAP LSVLPTTETD LPEETLDIAA TTPSLFPSSE
     CSMTANDLPE HITPVSEPPR LTQEGKSVAR QDSQETIIEE SLAVPNSAPS QIQEAENNAQ
     QGAETPVLGA SSLTAEPHNE VAPVISAVST KKKKRRVSEK PAPEPVRKQR VPGDYTLTPL
     LLAQPETAWI HCTNCNTAFV QSDAYYTRAN CSRCERHSKL YGYVWPKTAP AGKNDREERV
     LDHRLINRFL HPDDEAIIRG RKPWRERLGQ SSSSLAPSEE RGRQRESGTP QGTPGDNYRR
     SGRARRASAK AMAQ
//
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