GenomeNet

Database: UniProt
Entry: Q2H988
LinkDB: Q2H988
Original site: Q2H988 
ID   SET2_CHAGB              Reviewed;         894 AA.
AC   Q2H988;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   10-APR-2019, entry version 83.
DE   RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-36 specific;
DE            EC=2.1.1.43;
DE   AltName: Full=SET domain-containing protein 2;
GN   Name=SET2; ORFNames=CHGG_03216;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC
OS   6347 / NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Chaetomiaceae;
OC   Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium
RT   globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Histone methyltransferase that methylates histone H3 to
CC       form H3K36me. Involved in transcription elongation as well as in
CC       transcription repression (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00901};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- DOMAIN: The AWS and SET domains are necessary for transcription
CC       repression. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. SET2 subfamily. {ECO:0000255|PROSITE-ProRule:PRU00901}.
DR   EMBL; CH408030; EAQ91281.1; -; Genomic_DNA.
DR   RefSeq; XP_001229732.1; XM_001229731.1.
DR   ProteinModelPortal; Q2H988; -.
DR   SMR; Q2H988; -.
DR   STRING; 38033.XP_001229732.1; -.
DR   PRIDE; Q2H988; -.
DR   EnsemblFungi; EAQ91281; EAQ91281; CHGG_03216.
DR   GeneID; 4389690; -.
DR   eggNOG; KOG4442; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   InParanoid; Q2H988; -.
DR   OrthoDB; 453286at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046975; F:histone methyltransferase activity (H3-K36 specific); IEA:InterPro.
DR   GO; GO:0006354; P:DNA-templated transcription, elongation; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 1.10.1740.100; -; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR025788; Hist-Lys_N-MeTrfase_SET2_fun.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR013257; SRI.
DR   InterPro; IPR038190; SRI_sf.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   Pfam; PF17907; AWS; 1.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF08236; SRI; 1.
DR   Pfam; PF00397; WW; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF47676; SSF47676; 1.
DR   SUPFAM; SSF51045; SSF51045; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS51568; SAM_MT43_SET2_1; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   3: Inferred from homology;
KW   Chromosome; Complete proteome; Methyltransferase; Nucleus;
KW   Reference proteome; Repressor; S-adenosyl-L-methionine; Transcription;
KW   Transcription regulation; Transferase.
FT   CHAIN         1    894       Histone-lysine N-methyltransferase, H3
FT                                lysine-36 specific.
FT                                /FTId=PRO_0000269784.
FT   DOMAIN       72    126       AWS. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00562}.
FT   DOMAIN      128    245       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   DOMAIN      252    268       Post-SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00155}.
FT   DOMAIN      512    544       WW. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00224}.
FT   COMPBIAS    744    790       Pro-rich.
FT   COMPBIAS    863    892       Ala-rich.
SQ   SEQUENCE   894 AA;  99098 MW;  4C78E2A758B3ADF5 CRC64;
     MSPDDAKSAA DGTSVPENGT APKLSRKPSQ KLPRGPPPLF DHLPDATADA CDTFQVINDC
     LYGSKNMGSS DHDALDCDCA EEWHDGQNHA CGEDSDCINR ATKIECVSGD CNCGEGCENQ
     RFQRKQYANV SVIKTEKKGF GLRTDADLQA NDFVFEYVGE VINEPTFRNR TVKYDKEGIK
     HFYFMSLTKS EFVDATKKGN LGRFCNHSCN PNCYVDKWVV GDKLRMGIFA TRAIRAGEEL
     VFNYNVDRYG ADPQPCYCGE SNCVGFIGGK TQTERATKLP LATIEALGID DGDSWDTAVA
     KKPRKKKAHE DDEDYVNSVQ PRALDEDGVN KVMATLMQCK EKWIAVKLLS RLQATEDEHL
     RHRVVRMHGY QILKTTLNTF KDDTNVVLQI LDILYQLPRI TKNKISDSKV EGAVEPLASA
     AHEEVALAAK RLLDEWSKLE TAYRIPRKKH DHAGPIPGNS FEEERRNKDR EEPAKPTDPF
     ANIVIPTGPR STIPQRNANF FAGQQRPRKP PTNLPAGWFV NTDKTGRYYF YDATGRTQWQ
     RPLTPAIETP KVSAKAQQDQ KALQSIIDSL TKEPTPRHSA GHTPQRSTTP ATEPKKDKWR
     SLPLEKQMKI YENTHVVDRF HGKLPKEELK KFAREVNKKL VSSDYKNNRV EDPTSIPPKQ
     AKKVRKYAHD FFDRAVAKYT EHEKKKAHNP SKPTSGVPPG DVASSAATPA KDDVTMSDVE
     ADTSPGSSAG RKRKRDGDDE HDDPAESPGA PPSETPSVKR IKEDDAEGEG EPTTIPPPPT
     PPPPPADTPP TEEDRSMREQ EEALMRENEE AQRLEDEAQA EEGGKGSHEW NGRYHRTCAA
     GERAVEWRVG NGWCYGDDGH GRAAATTAAA AATAAAGSAG SLKTTLACFA FAPC
//
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