ID Q2H9N1_CHAGB Unreviewed; 847 AA.
AC Q2H9N1;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU363044};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU363044};
GN ORFNames=CHGG_03073 {ECO:0000313|EMBL:EAQ91138.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ91138.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|RuleBase:RU363044};
CC -!- SIMILARITY: Belongs to the helicase family.
CC {ECO:0000256|RuleBase:RU363044}.
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DR EMBL; CH408030; EAQ91138.1; -; Genomic_DNA.
DR RefSeq; XP_001229589.1; XM_001229588.1.
DR AlphaFoldDB; Q2H9N1; -.
DR GeneID; 4388790; -.
DR VEuPathDB; FungiDB:CHGG_03073; -.
DR eggNOG; KOG0987; Eukaryota.
DR HOGENOM; CLU_001613_8_0_1; -.
DR InParanoid; Q2H9N1; -.
DR OMA; NYDWIND; -.
DR OrthoDB; 2530803at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR010285; DNA_helicase_pif1-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049163; Pif1-like_2B_dom.
DR PANTHER; PTHR47642; ATP-DEPENDENT DNA HELICASE; 1.
DR Pfam; PF05970; PIF1; 1.
DR Pfam; PF21530; Pif1_2B_dom; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU363044};
KW DNA damage {ECO:0000256|RuleBase:RU363044};
KW DNA recombination {ECO:0000256|RuleBase:RU363044};
KW DNA repair {ECO:0000256|RuleBase:RU363044};
KW Helicase {ECO:0000256|RuleBase:RU363044};
KW Hydrolase {ECO:0000256|RuleBase:RU363044};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU363044};
KW Reference proteome {ECO:0000313|Proteomes:UP000001056};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..847
FT /note="ATP-dependent DNA helicase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004208658"
FT DOMAIN 653..685
FT /note="DNA helicase Pif1-like 2B"
FT /evidence="ECO:0000259|Pfam:PF21530"
FT REGION 368..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 847 AA; 95440 MW; 6907AB9A62B6B22F CRC64;
MADWFVSTLH SMLVTCLIGS AETASSPCPR NPLDNREHRG SRRFHIYRFS NPGLSMEDVI
VVLGGTAEAA AETAVTRKSC TKCNTEQNID QFLDARGNGR IVVNCLSCRH KKKLHVISLV
KRDYSAQEIC HILLGLPLQE DSRVVQSVDC RPHERHARPI DITADGDIQE SQTAYERYLR
RPASMDDVSY FEFLQDWNFK ARNPARWAIW QPPAMPRVLY YYPRYKPVRS HQQYSDFCRV
KLLLNHPHRQ SEQLLEVDDL QFDNYTSAYH YCLEHHDHQD DHYGTVDEPD PLPEEDEFER
GEDAGDITLE DWQEVARLVP ALQLPEEPAD LLGRRDIDVN CDWTRHIGRY WHDQFGTERL
LGATPWRRSR AKNENRQPPP LRLQIDGGGG TGTSYMVKVI SSHLQAEAAS YGRVSPIVRA
APTGVASNQI GGQTLHSLLR LPVDGNYRSL SETPTTLNAL QRGFRGIHYL VIDEKSMLGL
KTLAWIDQRL REVFPENRDE FFGGLSVILI GDFFQLPPVL NKPLYSTRDD LKGIEIVGRN
AYLSFDKSVF LTTIQRQQGE DQAPFRRALE ELRKADVSVP SWELLASRCS VKLSPEEVDS
FADALRIYPT KAQVVEYNHQ HMLGLDSPAI HVEAKHEGVG AEKVESSDAG NLAKRLPLCV
GCRVMLTRNL WADVGLVNGA QGTVYDISWK EGTDVLRDPS EVIMVAFDDY DGPGFTMPNG
EPLRSGEKLA VPILRVRHDF MVGANSCSRE QFPLLVSYAI TVHKSQGITL DKVVCDISAP
EFASGLSYVA VSRVKTLGGL MFKRPFDRSR IYRETPSPAM GLKLSDHGIR QLQALDAVAG
EVPSESN
//
