ID Q2HAD5_CHAGB Unreviewed; 372 AA.
AC Q2HAD5;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN ORFNames=CHGG_02819 {ECO:0000313|EMBL:EAQ90884.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ90884.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; CH408030; EAQ90884.1; -; Genomic_DNA.
DR RefSeq; XP_001229335.1; XM_001229334.1.
DR AlphaFoldDB; Q2HAD5; -.
DR STRING; 306901.Q2HAD5; -.
DR GeneID; 4388623; -.
DR VEuPathDB; FungiDB:CHGG_02819; -.
DR eggNOG; KOG1430; Eukaryota.
DR HOGENOM; CLU_007383_6_8_1; -.
DR InParanoid; Q2HAD5; -.
DR OMA; STAHWFD; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001056}.
FT DOMAIN 13..288
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 372 AA; 40967 MW; C84F51FC0E043E5A CRC64;
MAPEKKPILG SVMVIGGCGF LGHHVVRVLL RDYNCSVSVI DLRCTRNRRP ESDGVSYHEA
DITDAAKLES IFSQTKPDVV IHTASPPAQS NDSVSHALFK KVNVDGTAAV VKACQQTGVK
ALVYTSSASV MSDNRSDLIN ADERWPTVRG SQQSEYYSET KAAAEELVLA ANRAPEAPNL
LTCSIRPSGI MGEGDTMVLY HLINILRQGR SGVQVGNNDN LFDFTYVENV AHGHLLAARA
LLLTAASKTI PLDTERVDGE AFLITNDSPV YFWDFARAVW AAAGSPHGTE HVRVLPRSVG
MVLGYCSEWF FWAIGKPPTF NRQRIVYSCM TRYYDISKAK KRLGYQPLVS LEDGIKRSVK
WTLEQQESAK KA
//