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Database: UniProt
Entry: Q2HAD8
LinkDB: Q2HAD8
Original site: Q2HAD8 
ID   PRP5_CHAGB              Reviewed;        1064 AA.
AC   Q2HAD8;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   18-SEP-2019, entry version 66.
DE   RecName: Full=Pre-mRNA-processing ATP-dependent RNA helicase PRP5;
DE            EC=3.6.4.13;
GN   Name=PRP5; ORFNames=CHGG_02816;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC
OS   6347 / NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Chaetomiaceae;
OC   Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium
RT   globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: ATP-dependent RNA helicase involved spliceosome assembly
CC       and in nuclear splicing. Catalyzes an ATP-dependent conformational
CC       change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2
CC       snRNP association with intron RNA (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX46/PRP5
CC       subfamily. {ECO:0000305}.
DR   EMBL; CH408030; EAQ90881.1; -; Genomic_DNA.
DR   RefSeq; XP_001229332.1; XM_001229331.1.
DR   SMR; Q2HAD8; -.
DR   STRING; 38033.XP_001229332.1; -.
DR   EnsemblFungi; EAQ90881; EAQ90881; CHGG_02816.
DR   GeneID; 4388898; -.
DR   eggNOG; KOG0334; Eukaryota.
DR   eggNOG; ENOG410XSQV; LUCA.
DR   InParanoid; Q2HAD8; -.
DR   OrthoDB; 245118at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0071004; C:U2-type prespliceosome; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:1990446; F:U1 snRNP binding; IEA:EnsemblFungi.
DR   GO; GO:1990447; F:U2 snRNP binding; IEA:EnsemblFungi.
DR   GO; GO:1903241; P:U2-type prespliceosome assembly; IEA:EnsemblFungi.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase; mRNA processing;
KW   mRNA splicing; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN         1   1064       Pre-mRNA-processing ATP-dependent RNA
FT                                helicase PRP5.
FT                                /FTId=PRO_0000256033.
FT   DOMAIN      460    638       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      665    813       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     473    480       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       429    457       Q motif.
FT   MOTIF       586    589       DEAD box.
FT   COMPBIAS    869    944       Ala-rich.
SQ   SEQUENCE   1064 AA;  114993 MW;  B805B9BF997B6314 CRC64;
     MTITEAVAVM EEAIETVVGH ATEAQTERDR QIAEDNGAEM VTGTTAPAKS TPTQAQTEAE
     KKAERLRKLQ AMKEKHAQKE AKEAAVTAGS TRMLLAEMDQ KASGTPGPNS PVAGAMSPAP
     TSPAPPMPYA GKFDPKAIAK SSKAARPQSP TRLGDVKLAA PAPKPLGLKK EANLKGAGLL
     PANRAKSSTK RKIDMDDEEV IKRKLVKLPD FVPENADSTP DAEGEGEEEA DDLDLLMAQN
     EEEMAEAHRV LQERRDERIQ KEGMAMDVDT ETPNGETKDE AENEANVESK DEAVLPAPSM
     DVDEDVDPLD AFMADLEQTG SAGGIGSVPA RQKQKAGKGF EPEAYFSDDD YGYEEDKADP
     SSILAMASKK KKKDIPTIDY SKIELNQIRK NFWVEPQELS QMTEDDIADL RLELDGIKVS
     GKNVPKPVQK WSQCGLTRPI LDVVEGLGYE KPTSIQMQAL PVIMSGRDVI GVAKTGSGKT
     MAFVLPMLRH IKDQDPVTGD DGAIALIMTP TRELCTQIYS DLLPFAKALK LRAIAAYGGN
     AIKDQIAELK RGAEIIVATP GRMIDLLAAN SGRVTNLKRA TYLVLDEADR MFDMGFEPQV
     MKIFNNVRPD RQTILFSATM PRIIDALTKK VLREPVEIQV GGRSVVAPEI TQIVEILDEG
     KKFVRLLELL GELYADDDDV RALIFVERQE KADDLLREVL RRGYGCMSIH GGKDQEDRNS
     TISDFKKGVC PIMIATSVAA RGLDVKQLKL VVNYDAPNHL EDYVHRAGRT GRAGNTGTAV
     TFITEEQENC APGIAKALEQ SGQPVPEQLN EMRKAWKEKV KTGKAKDASG FGGKGLERLD
     KEREAARVRE RKTHKAEGEE DDFKEEETAE DAAKKDKAKS AILAAASAIV SRESAKADAS
     EAKPLPAAAE GAVKGGVTVN AGKGGALDKA ASAISEINAR LARAGQLRPG QPIDNKGPDA
     GAFHATLEIN DFPQKARWAV TNRTNVAKIL EATSTSITTK GNYYPPGKEP PSGSDPKLYI
     LIEGDTELAV GKALSELTRL LREGTIAAAD AESRAPASGR YTIA
//
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