ID Q2HAM1_CHAGB Unreviewed; 821 AA.
AC Q2HAM1;
DT 21-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=DNA mismatch repair protein S5 domain-containing protein {ECO:0000259|SMART:SM01340};
GN ORFNames=CHGG_02733 {ECO:0000313|EMBL:EAQ90798.1};
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901 {ECO:0000313|EMBL:EAQ90798.1, ECO:0000313|Proteomes:UP000001056};
RN [1] {ECO:0000313|Proteomes:UP000001056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970
RC {ECO:0000313|Proteomes:UP000001056};
RX PubMed=25720678; DOI=10.1128/genomeA.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CH408030; EAQ90798.1; -; Genomic_DNA.
DR RefSeq; XP_001229249.1; XM_001229248.1.
DR AlphaFoldDB; Q2HAM1; -.
DR STRING; 306901.Q2HAM1; -.
DR GeneID; 4389242; -.
DR VEuPathDB; FungiDB:CHGG_02733; -.
DR eggNOG; KOG1978; Eukaryota.
DR HOGENOM; CLU_011171_4_0_1; -.
DR InParanoid; Q2HAM1; -.
DR OMA; GIAICTR; -.
DR OrthoDB; 1369806at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF41; MISMATCH REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05820)-RELATED; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000001056}.
FT DOMAIN 216..365
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 235..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..547
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 821 AA; 89522 MW; 93376B2BF15A188E CRC64;
MSIVPLPEAT VRNLGSSLVI TSPVVLLKEL VDNAIDAGAT SIDVLVSPNT IDKIEVRDNG
HGISPADFGY LGCPGHTSKL TSLDELDTLG GKTLGFRGVA LASANTLANV SLTTRVPTEH
VAAAISLAKR GGVDTLRYVG APVGTTVRVT NLFSHMPVRS QVTVKEAPRN LARMNELLQS
YVLARPTVKL RFTVLKTPNL SWSYAPAANG EIKAAAIQLF GTELASQCVF KTSPSQITPG
GDKTSRDENV PDCSPKEGTR VIFEALLPRP TADPQKISKG AFISVDARPL SAFRGAAKKL
LSIFKKRIGD HFASIHSETI LRNPFIRLNI RCPPSTYDVN VEPSKEDVIF KEEHNIIDQF
ESFLSYVYPA SGVGQSRPLP ITTTGTSVEA PGRKTTNISN SSLSLQATAL SWRVDMSSGL
DGMSDDEIGD QATGHTPQYT QQVVEAEARE GDNEQPLNEG LNPWSIAKLT GKPKNNAPQD
QGPVQDTRRE TQPQSTELST TDPFSVSSPP HMQESSLRHS RGPQHSPRDR HRNPESQGRR
FKDFTGHKQN KPTVNSTRLS NQQNRPRRYH VLQSPPTSSP HDQDRERVVS RDRPRPQNLT
GPTRIIQSRL PFDRNSNRLR LRDHPDLGLD LDQQVSETTR RDMLARNPPI TRLVDVEDED
TMTGTFVGVD SAGGATVQHI SPVSLSCTVG GDESATEAQL AGKPDENTSQ PLLRTDDPRA
RLIQQQRLTA ASVRKKPKRL KTGQLPLETI PCDSKTCALL LGMAVDASSL AQLLTEASRF
DTWLVDGELR GAFEDGTEPK DTARLMEPLL ARLAYGTTVN A
//
