GenomeNet

Database: UniProt
Entry: Q2HCV7
LinkDB: Q2HCV7
Original site: Q2HCV7 
ID   ROK1_CHAGB              Reviewed;         667 AA.
AC   Q2HCV7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   18-SEP-2019, entry version 63.
DE   RecName: Full=ATP-dependent RNA helicase ROK1;
DE            EC=3.6.4.13;
GN   Name=ROK1; ORFNames=CHGG_01947;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC
OS   6347 / NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Sordariomycetidae; Sordariales; Chaetomiaceae;
OC   Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium
RT   globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: ATP-dependent RNA helicase involved in 40S ribosomal
CC       subunit biogenesis. Required for the processing and cleavage of
CC       35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Interacts with the U3 snoRNA and is associated with the
CC       90S and 40S pre-ribosomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX52/ROK1
CC       subfamily. {ECO:0000305}.
DR   EMBL; CH408029; EAQ93712.1; -; Genomic_DNA.
DR   RefSeq; XP_001221168.1; XM_001221167.1.
DR   STRING; 38033.XP_001221168.1; -.
DR   EnsemblFungi; EAQ93712; EAQ93712; CHGG_01947.
DR   GeneID; 4387429; -.
DR   eggNOG; KOG0344; Eukaryota.
DR   eggNOG; ENOG410XQS8; LUCA.
DR   InParanoid; Q2HCV7; -.
DR   OrthoDB; 400908at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 2.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    667       ATP-dependent RNA helicase ROK1.
FT                                /FTId=PRO_0000256042.
FT   DOMAIN      224    447       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      432    581       Helicase C-terminal.
FT   NP_BIND     237    244       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       175    203       Q motif.
FT   MOTIF       394    397       DEAD box.
FT   COMPBIAS    138    163       Lys-rich.
SQ   SEQUENCE   667 AA;  72549 MW;  90CC2DA8844B8B0A CRC64;
     MDILRVLSRG IKPNPKSKAQ AGGATTQLPS AGALPRPQLF HDPVGSRGKK RKRRRGAQDD
     EPEGDDQELS DVDYFAPKKA APEAAPTDVE ESPKKRKIKL LDEDECRQIL RSHRLKLTIL
     SDQPQAEAKT EAEEPASKKK SSKKKKKETE GKDKKDKKDE HKKQIFPQPL TSFGELRHTY
     DVSPQLAANI AAQGFRVPTE VQMASLPLLL QPTTALKKSE GADIPNIDNG ADFLAVAPTG
     SGKTITFLIP AIDGVLRRRA EEGRDTDQHV LEAVVVAPTR ELATQIVNEG RKLAIGTGVR
     VVLMKRALKL DVEEVADEKS KDLEEGSGSE QGSGDEESEG EEESEGEEGK TSKEAKPLAR
     VDILVTTPKI LLNFLSGKAG ARRLLPSVRS LILDEADVLL DPLFRKQTMA ICRACTHPNV
     ALTCWSATMA SNVEALVTKH LLQARQEDRQ PTPALHDELK YDIPLEAGGS ARVAVLHSSM
     ADSARSKIMA RFRAGEVWVL VTTDVLARGV DFAGVNGVVN YDVPTSAAAY VHRAGRTGRA
     GREGGVAVTF YTKDDIPFVK SVANVIAASE KQAGVQADGG GGGTVQKWLL DALPKVAKED
     KRKLKVRGVE SRRTGGKATI TTKSSWERRR EHNRAQAVEA SKRRKRQRRE EGPAAGEAEG
     EWGGLED
//
DBGET integrated database retrieval system