ID MUTL_RHOP2 Reviewed; 597 AA.
AC Q2ISE2;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=RPB_4176;
OS Rhodopseudomonas palustris (strain HaA2).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Rhodopseudomonas.
OX NCBI_TaxID=316058;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HaA2;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M.,
RA Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Pelletier D.A.,
RA Kyrpides N., Anderson I., Oda Y., Harwood C.S., Richardson P.;
RT "Complete sequence of Rhodopseudomonas palustris HaA2.";
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP000250; ABD08868.1; -; Genomic_DNA.
DR RefSeq; WP_011443052.1; NC_007778.1.
DR AlphaFoldDB; Q2ISE2; -.
DR SMR; Q2ISE2; -.
DR STRING; 316058.RPB_4176; -.
DR KEGG; rpb:RPB_4176; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_2_5; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000008809; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair.
FT CHAIN 1..597
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000010062"
SQ SEQUENCE 597 AA; 64429 MW; AAF3B6C7E5D579F0 CRC64;
MPVRQLPETI VNRIAAGEVV ERPASVVKEL VENAIDAGAS RIDIFSDGGG RRKIVIADDG
SGMTRADLAL AVDRHATSKL DDEDLLQIRT LGFRGEALPS IGAVARLTIT TRHAGEPHAW
TLGVEGGDKS PIAPAALSQG TRVEVADLFF ATPARLKFLK TDRTEAEAIR DVVRRLAMAR
PDIAFTLAGE ERAPVTWAAA LPGAPGQLIR LGDILGADFR ANAIEVRSER EGVAVEGFAA
SPALTRANAL GQYLFVNGRP VRDKLILGAV RAAYSDYLPR DRHPVVALFV TLESREVDAN
VHPAKTEVRF RNAGLVRALI VHALKEGLAR EGRRTAANSA GSVISTFRPA SMPAANWDWR
ASPSYPVGGS AIDAPSFAER PQAAFDVGGP SADIRTHEVA PDLLDRPLGA ARTQIHETYI
VSQTRDGLIV VDQHAAHERI VYERLKASLA ANGVQRQILL IPDIVEMDEA TVERLVARAD
ELAQFGLVVE SFGPGAVAVR ETPSLLGKTD AASLLRDLAE HMAEWDEALP LERRLMHVAA
TMACHGSVRA GRVLKPEEMN ALLREMEATP NSGQCNHGRP TYVELTLTDI EKLFGRR
//
