ID Q2JGD4_FRACC Unreviewed; 812 AA.
AC Q2JGD4;
DT 07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 07-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN OrderedLocusNames=Francci3_0270 {ECO:0000313|EMBL:ABD09658.1};
OS Frankia casuarinae (strain DSM 45818 / CECT 9043 / HFP020203 / CcI3).
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=106370 {ECO:0000313|EMBL:ABD09658.1, ECO:0000313|Proteomes:UP000001937};
RN [1] {ECO:0000313|EMBL:ABD09658.1, ECO:0000313|Proteomes:UP000001937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45818 / CECT 9043 / CcI3
RC {ECO:0000313|Proteomes:UP000001937};
RX PubMed=17151343; DOI=10.1101/gr.5798407;
RA Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA Benson D.R.;
RT "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT reflect host range and host plant biogeography.";
RL Genome Res. 17:7-15(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DnaX/STICHEL family.
CC {ECO:0000256|ARBA:ARBA00006360}.
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DR EMBL; CP000249; ABD09658.1; -; Genomic_DNA.
DR RefSeq; WP_011434737.1; NC_007777.1.
DR AlphaFoldDB; Q2JGD4; -.
DR STRING; 106370.Francci3_0270; -.
DR KEGG; fra:Francci3_0270; -.
DR eggNOG; COG2812; Bacteria.
DR HOGENOM; CLU_006229_3_5_11; -.
DR OrthoDB; 9810148at2; -.
DR Proteomes; UP000001937; Chromosome.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd18137; HLD_clamp_pol_III_gamma_tau; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR022754; DNA_pol_III_gamma-3.
DR InterPro; IPR012763; DNA_pol_III_sug/sutau_N.
DR InterPro; IPR045085; HLD_clamp_pol_III_gamma_tau.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02397; dnaX_nterm; 1.
DR PANTHER; PTHR11669:SF0; PROTEIN STICHEL; 1.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR Pfam; PF13177; DNA_pol3_delta2; 1.
DR Pfam; PF12169; DNA_pol3_gamma3; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000313|EMBL:ABD09658.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001937};
KW Transferase {ECO:0000313|EMBL:ABD09658.1}.
FT DOMAIN 36..177
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 386..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..417
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..711
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 812 AA; 82833 MW; 4FD879B1E1DE1F03 CRC64;
MSTALYNRYR PATFAQVVGQ EHVTDALRKA LRTGRLHHAY LFSGPRGCGK TSSARILAAS
LNCVQGPTPE PCGVCDECVG IRTGASMDVT EIDAASHGLV DDARDLRERA FFAPASARFK
VFVVDEAHMV TAAAFNALLK VVEEPPPYLK FVFATTEPDK VIPTIRSRTH HYAFRLVPPG
VLREHLASVC AREGVVVDPA VLPLIVRAGA GSVRDSLSVL DQLLAGADDD GLRYDRAVAL
LGMTDGVLLD ETVDALADRD GAALFTVVDK VVSAGHDPRR FATDLLDRFR DLIVMAAVPD
ADARGLLESF SPDQIDRMRA QTTRMGPAEL SRTADVLHNG LVEMRGTASP RLILELIMAR
ALLPTASTDP AALLTRLERL ERRAVLGGEE PEPGPPAPLP VGRAPAPVHP PAADPEPMPL
AVRASARTGP VSRPAAGPQP GSPGPAFTSG DRPSGPAGVP GTAGTPGTGR IDAAGLRMLW
DELLALAGRH SRKTHAILKD HATVADVRGD EVVLAFATPT MGRMFGQGNN AELFCTVLAE
RLGGTWRVTV APAGGSGRGS GRPAAGPGPG GGGYSGPPGP SKASGFAGSG GAPGPTGQAG
ASRSPAPAPA PARAAGPAGQ SSGPSWGPRL DPPVGAENRA VSPGSPRAMP GQMRGPAGLS
PDTGNGYGGS TDGTEGGTTD PGRGPDGYGD PREHGDPREH GDPREHGDSH GAGHGSTGPG
PGPEGGPGPE GDRPWSATGR DGSSPGPANG VAAAASAPPA GDEPGPRRED EPSLDDEAVP
SGPGGARGGE EAAVSLLRSG LGATIIEQIS SG
//
