ID Q2K8B4_RHIEC Unreviewed; 1081 AA.
AC Q2K8B4;
DT 07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 07-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=Adenylate/guanylate cyclase protein {ECO:0000313|EMBL:ABC90922.1};
GN OrderedLocusNames=RHE_CH02138 {ECO:0000313|EMBL:ABC90922.1};
OS Rhizobium etli (strain CFN 42 / ATCC 51251).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX NCBI_TaxID=347834 {ECO:0000313|EMBL:ABC90922.1, ECO:0000313|Proteomes:UP000001936};
RN [1] {ECO:0000313|EMBL:ABC90922.1, ECO:0000313|Proteomes:UP000001936}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CFN 42 / ATCC 51251 {ECO:0000313|Proteomes:UP000001936};
RX PubMed=16505379; DOI=10.1073/pnas.0508502103;
RA Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I.,
RA Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A.,
RA Jimenez-Jacinto V., Collado-Vides J., Davila G.;
RT "The partitioned Rhizobium etli genome: genetic and metabolic redundancy in
RT seven interacting replicons.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006).
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DR EMBL; CP000133; ABC90922.1; -; Genomic_DNA.
DR RefSeq; WP_011425404.1; NC_007761.1.
DR AlphaFoldDB; Q2K8B4; -.
DR KEGG; ret:RHE_CH02138; -.
DR eggNOG; COG2114; Bacteria.
DR eggNOG; COG2888; Bacteria.
DR eggNOG; COG3899; Bacteria.
DR HOGENOM; CLU_004435_0_1_5; -.
DR OrthoDB; 9785312at2; -.
DR Proteomes; UP000001936; Chromosome.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR025874; DZR.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF12773; DZR; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001936};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 78..210
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1081 AA; 117542 MW; ED040C560A0B5DC9 CRC64;
MDCAGCGFDI QSGFAFCPRC GAKQPLSCAA CGYPCQPDFA FCPRCGASIS GKAQPAAKPA
IETAPAEADS DADRRPVTVL FADLCGFTSL SEQIDPEVMR ALQNELFEEM TLAVEAYGGF
VDKFVGDALL ALFGAPVAHE DDPVRALNAA LDMIDRAAAV GTRWQSRAGV PLRLHIGINS
GPVVTGGFGA ASTKSYSVTG DTVNTAQRLQ SMAGENDILV GPLTYRLTRH AFAFESLGAQ
ALRGKSGNVL VHRLTGLLEA PHTARGLESF GLRAPMVGRD ADMSRLLTCL DLACGGAAQL
VRLIGEAGIG KSRLASEFVG VAADADRFPG LAIRKATCSP LGEQSYGTLA AVVRSAYGIG
ERDDRDKTRE LLTTGFRALD LRSDDIDALL PLFLHVLGLG DPDGALRHIE PEQLRRQIFY
AVRTVFERRL AQGPLLLVIE DLHWADAASL EVLRFMMDRL ERSRLMLLAI YRPTLQTDPL
NSNRVSVTVQ RLAPLLAADG QKLLAAFFGE GHGKLPAPMR KRILDRAGGN PLFIEEILRG
LIDMGTLHND GQRWHVAAED ADVDIPVNLQ ALLLARVDRL PQEIRRLAQE AAVVGPKFDT
ALLRTVATDP AGVDAALDYL CDANIIEELR GPDAAISPGY RFSQTLMHDV AYHNLLLQRR
MELHRRVGRA LERQYGVAPD RAEHLAQLGH HFSLTTEKAK GASYLMAAGD MARKIYANDD
AMRLYRQALA AFADEPEMTP EQSALLERLG DLCGPAGQRE AALNHYQRAL ATHRAKDDRI
AAARILRKIS RLHLEAGRRD QAESRCAEAE AMIAPIDAPI EHAHLLQERG HLAFRTGDQA
AAVEWATQAL QCLQTLPIDG TTEAGREAAR AMAEALNTKG AALARLGRRR DAVQEVERSL
SVAEKADLQS AACRAYSNLG VLYTIVDPAN AIRICRRGLE VATRIGDLGF QARLLANLAV
SCCTFTDRCG AEGVPAAEKA VEIDRALDQR DHLSVPLIVL GQIHQCHGQP KLARKYYEEA
LEVAKEIDEP QLLFPCYDGL ATLSLEHDDM DEAERYFALA QDVCIRHKLD PGTFVVLPFL
D
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