ID Q2KJ85_BOVIN Unreviewed; 370 AA.
AC Q2KJ85;
DT 07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT 07-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=Solute carrier family 10 (Sodium/bile acid cotransporter family), member 1 {ECO:0000313|EMBL:AAI05472.1};
DE SubName: Full=Solute carrier family 10 member 1 {ECO:0000313|Ensembl:ENSBTAP00000002446.5};
GN Name=SLC10A1 {ECO:0000313|EMBL:AAI05472.1,
GN ECO:0000313|Ensembl:ENSBTAP00000002446.5,
GN ECO:0000313|VGNC:VGNC:34659};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI05472.1};
RN [1] {ECO:0000313|EMBL:AAI05472.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hereford {ECO:0000313|EMBL:AAI05472.1};
RC TISSUE=Fetal liver {ECO:0000313|EMBL:AAI05472.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000002446.5, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002446.5,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0007829|PDB:7VAE}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.55 ANGSTROMS) OF 1-320, AND DISULFIDE
RP BONDS.
RX PubMed=35580629; DOI=10.1038/s41586-022-04845-4;
RA Asami J., Kimura K.T., Fujita-Fujiharu Y., Ishida H., Zhang Z., Nomura Y.,
RA Liu K., Uemura T., Sato Y., Ono M., Yamamoto M., Noda T., Shigematsu H.,
RA Drew D., Iwata S., Shimizu T., Nomura N., Ohto U.;
RT "Structure of thebile acid transporterand HBV receptor NTCP.";
RL Nature 606:1021-1026(2022).
RN [4] {ECO:0000313|Ensembl:ENSBTAP00000002446.5}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000002446.5};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528}.
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DR EMBL; BC105471; AAI05472.1; -; mRNA.
DR EMBL; BC146029; AAI46030.1; -; mRNA.
DR RefSeq; NP_001039804.1; NM_001046339.1.
DR PDB; 7VAE; EM; 3.55 A; A=1-320.
DR EMDB; EMD-31838; -.
DR STRING; 9913.ENSBTAP00000002446; -.
DR PaxDb; 9913-ENSBTAP00000002446; -.
DR Ensembl; ENSBTAT00000002446.6; ENSBTAP00000002446.5; ENSBTAG00000001881.6.
DR GeneID; 532890; -.
DR KEGG; bta:532890; -.
DR CTD; 6554; -.
DR VEuPathDB; HostDB:ENSBTAG00000001881; -.
DR VGNC; VGNC:34659; SLC10A1.
DR eggNOG; KOG2718; Eukaryota.
DR GeneTree; ENSGT00950000182808; -.
DR HOGENOM; CLU_034788_7_5_1; -.
DR OMA; CYEKIKP; -.
DR OrthoDB; 3035577at2759; -.
DR TreeFam; TF315811; -.
DR Reactome; R-BTA-159418; Recycling of bile acids and salts.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000001881; Expressed in liver and 65 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008508; F:bile acid:sodium symporter activity; IBA:GO_Central.
DR GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR NCBIfam; TIGR00841; bass; 1.
DR PANTHER; PTHR10361; SODIUM-BILE ACID COTRANSPORTER; 1.
DR PANTHER; PTHR10361:SF40; SODIUM_BILE ACID COTRANSPORTER; 1.
DR Pfam; PF01758; SBF; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:7VAE}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 26..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 60..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 154..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DISULFID 96..266
FT /evidence="ECO:0007829|PDB:7VAE"
SQ SEQUENCE 370 AA; 40531 MW; D73D2BEEE49F2C08 CRC64;
MEAFNESSPF NFSLPHNFGK RPTDRALSVI LVIMLLTIML SLGCTMEFSK IKAHFWRPKG
LAVALVAQFG IMPLTAFGLG KFFQLNNVEA LAILICGCSP GGNLSNVFAL AIKGDMNLSI
VMTTCSTFFA LGMMPLLLYL YSRGIYDGSL KDKVPYGGIM ISLILILIPC TIGIILKSKR
PQYVRYVTKG GIILLLLCSV AVVVLSAINV GKSILFVMTP HLLATSSLMP FIGFLLGYLL
SALFCLNGRC KRTVSMETGC QNIQLCSTIL NVTFPPEVIG PLFFFPLLYM IFQVGEGLLL
VAIFRCYEKF KTPRDDTKMT YKVDATEETL PTALGNGTYK GEECNIGFTS GFPKELDSGQ
KATEQLNMAN
//
