ID Q2LWM5_SYNAS Unreviewed; 731 AA.
AC Q2LWM5;
DT 21-FEB-2006, integrated into UniProtKB/TrEMBL.
DT 21-FEB-2006, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Zinc-binding dehydrogenase {ECO:0000313|EMBL:ABC78482.1};
GN ORFNames=SYN_02677 {ECO:0000313|EMBL:ABC78482.1};
OS Syntrophus aciditrophicus (strain SB).
OC Bacteria; Thermodesulfobacteriota; Syntrophia; Syntrophales; Syntrophaceae;
OC Syntrophus.
OX NCBI_TaxID=56780 {ECO:0000313|EMBL:ABC78482.1, ECO:0000313|Proteomes:UP000001933};
RN [1] {ECO:0000313|EMBL:ABC78482.1, ECO:0000313|Proteomes:UP000001933}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB {ECO:0000313|EMBL:ABC78482.1,
RC ECO:0000313|Proteomes:UP000001933};
RX PubMed=17442750; DOI=10.1073/pnas.0610456104;
RA McInerney M.J., Rohlin L., Mouttaki H., Kim U., Krupp R.S.,
RA Rios-Hernandez L., Sieber J., Struchtemeyer C.G., Bhattacharyya A.,
RA Campbell J.W., Gunsalus R.P.;
RT "The genome of Syntrophus aciditrophicus: life at the thermodynamic limit
RT of microbial growth.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:7600-7605(2007).
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DR EMBL; CP000252; ABC78482.1; -; Genomic_DNA.
DR RefSeq; WP_011418501.1; NC_007759.1.
DR AlphaFoldDB; Q2LWM5; -.
DR STRING; 56780.SYN_02677; -.
DR KEGG; sat:SYN_02677; -.
DR eggNOG; COG0673; Bacteria.
DR eggNOG; COG1063; Bacteria.
DR HOGENOM; CLU_024115_0_0_7; -.
DR InParanoid; Q2LWM5; -.
DR OrthoDB; 9782091at2; -.
DR Proteomes; UP000001933; Chromosome.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd08255; 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_like; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43377; BILIVERDIN REDUCTASE A; 1.
DR PANTHER; PTHR43377:SF6; GFO_IDH_MOCA DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001933}.
FT DOMAIN 183..298
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
FT DOMAIN 404..523
FT /note="Gfo/Idh/MocA-like oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01408"
SQ SEQUENCE 731 AA; 78871 MW; 118471A4CE52CE0E CRC64;
MKQVFISGQG QIDIIDVPIP SLLSGGILVH NAYSLISAGT EGAAVTKHSG VQGLYEKALN
SRDKMGQVWA MVQGQGMSNT LKLIRDKLND YSPIGYSCAG VVLETDKDDL GFKPDQRVAC
MGTGFANHAE YVVVPKNLAV PLSDNVNFDE AAFAAIACIA MQGIRRLELS PGERVGVIGL
GLIGQIALRL ATVMGYQAYG FDISDHRVAK AARHSQASLV VNSASTDPVS VAMEASHGNG
LDGIVICASG KADSVINQAF MLCRKRGRVS VVGDIGLELE RAKMYSKELE VRLSCSYGVG
RYDPDYELGG RDYPLPHVRW TERRNLEFFI HLLAEKRLDL GDLVSAKIGI EDAKKAYSLI
KAGNSDVYGV LLDYHLPPQP QLPQHAFICR YDTNTLAQDK KCLQIGLIGV GGYAKNVHVP
NIQKLENVII RALSSKSGAT AAVVAKKVKA AYATSDISEM LSDKQLDAVV ISTRHASHAK
LVLAALSAGK HVFVEKPMAI TLADCLQIVS LQQETGLVLR VGFNRRFSPY LQEMKRAVGI
GRKLFNVRVN VGQVGNHWSN TVEEGGRLLG EGVHFFDLAN WMMDCNPVTV SAQFLGEVNV
LNPNASVTIR YEDGSIANVV YTTVGHTGLG KEHFELFGNG RSIVMDDYKM IKSFGCGVAA
PRKYKKNKGQ HGAILEFSRA IKNGDGGGGA NAVAGLWATA ITEAALKSAE TNRTIDMAFI
FNTTKQVSAI L
//
