ID Q2LX12_SYNAS Unreviewed; 256 AA.
AC Q2LX12;
DT 21-FEB-2006, integrated into UniProtKB/TrEMBL.
DT 21-FEB-2006, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=pre-crRNA processing endonuclease {ECO:0000256|PIRNR:PIRNR029950};
DE EC=3.1.-.- {ECO:0000256|PIRNR:PIRNR029950};
GN ORFNames=SYN_02477 {ECO:0000313|EMBL:ABC78622.1};
OS Syntrophus aciditrophicus (strain SB).
OC Bacteria; Thermodesulfobacteriota; Syntrophia; Syntrophales; Syntrophaceae;
OC Syntrophus.
OX NCBI_TaxID=56780 {ECO:0000313|EMBL:ABC78622.1, ECO:0000313|Proteomes:UP000001933};
RN [1] {ECO:0000313|EMBL:ABC78622.1, ECO:0000313|Proteomes:UP000001933}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB {ECO:0000313|EMBL:ABC78622.1,
RC ECO:0000313|Proteomes:UP000001933};
RX PubMed=17442750; DOI=10.1073/pnas.0610456104;
RA McInerney M.J., Rohlin L., Mouttaki H., Kim U., Krupp R.S.,
RA Rios-Hernandez L., Sieber J., Struchtemeyer C.G., Bhattacharyya A.,
RA Campbell J.W., Gunsalus R.P.;
RT "The genome of Syntrophus aciditrophicus: life at the thermodynamic limit
RT of microbial growth.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:7600-7605(2007).
CC -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC repeat) is an adaptive immune system that provides protection against
CC mobile genetic elements (viruses, transposable elements and conjugative
CC plasmids). CRISPR clusters contain spacers, sequences complementary to
CC antecedent mobile elements, and target invading nucleic acids. CRISPR
CC clusters are transcribed and processed into CRISPR RNA (crRNA).
CC {ECO:0000256|PIRNR:PIRNR029950}.
CC -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas5 family.
CC Subtype I-C/Dvulg subfamily. {ECO:0000256|PIRNR:PIRNR029950}.
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DR EMBL; CP000252; ABC78622.1; -; Genomic_DNA.
DR RefSeq; WP_011418639.1; NC_007759.1.
DR AlphaFoldDB; Q2LX12; -.
DR STRING; 56780.SYN_02477; -.
DR KEGG; sat:SYN_02477; -.
DR eggNOG; ENOG502Z82V; Bacteria.
DR HOGENOM; CLU_093736_0_0_7; -.
DR InParanoid; Q2LX12; -.
DR OrthoDB; 5621871at2; -.
DR Proteomes; UP000001933; Chromosome.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-UniRule.
DR GO; GO:0043571; P:maintenance of CRISPR repeat elements; IEA:UniProtKB-UniRule.
DR CDD; cd09651; Cas5_I-C; 1.
DR Gene3D; 3.30.70.2660; -; 1.
DR InterPro; IPR021124; CRISPR-assoc_prot_Cas5.
DR InterPro; IPR013422; CRISPR-assoc_prot_Cas5_N.
DR InterPro; IPR010155; CRISPR-assoc_prot_Cas5d.
DR NCBIfam; TIGR01876; cas_Cas5d; 1.
DR NCBIfam; TIGR02593; CRISPR_cas5; 1.
DR Pfam; PF09704; Cas_Cas5d; 1.
DR PIRSF; PIRSF029950; Cas_CT1134; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118,
KW ECO:0000256|PIRNR:PIRNR029950};
KW Endonuclease {ECO:0000256|PIRNR:PIRNR029950};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR029950};
KW Nuclease {ECO:0000256|PIRNR:PIRNR029950};
KW Reference proteome {ECO:0000313|Proteomes:UP000001933};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR029950}.
SQ SEQUENCE 256 AA; 29671 MW; 3A0C6ABE4CAAF773 CRC64;
MHETAKNTIE FKLWGRFALF TDPLTKIGGE KCSYHVPTYE ALKGVCKSIY WKPTIIWVID
AVRVIRRIRT QTKGTKPLEY NGRNTLAIYT FLTGFDENEK DVNRKHGVEY QVRAHFEWNK
CNKLLEKDRV DGKHFAIAKR MLELGGRQDV FLGTRDCQGY VEPCIFGEGE GAYDAIDEIG
YGLMFHGFDY PDETGINNLY ARFWYPKLKK GVLTFERPEN CKPELKKFVR EMVPKTFGTE
NIKSVDVETE ELGVLE
//
