GenomeNet

Database: UniProt
Entry: Q2NAA0_ERYLH
LinkDB: Q2NAA0_ERYLH
Original site: Q2NAA0_ERYLH 
ID   Q2NAA0_ERYLH            Unreviewed;       325 AA.
AC   Q2NAA0;
DT   07-FEB-2006, integrated into UniProtKB/TrEMBL.
DT   07-FEB-2006, sequence version 1.
DT   24-JAN-2024, entry version 105.
DE   RecName: Full=Proline iminopeptidase {ECO:0000256|ARBA:ARBA00021843, ECO:0000256|PIRNR:PIRNR006431};
DE            Short=PIP {ECO:0000256|PIRNR:PIRNR006431};
DE            EC=3.4.11.5 {ECO:0000256|ARBA:ARBA00012568, ECO:0000256|PIRNR:PIRNR006431};
DE   AltName: Full=Prolyl aminopeptidase {ECO:0000256|PIRNR:PIRNR006431};
GN   OrderedLocusNames=ELI_06495 {ECO:0000313|EMBL:ABC63391.1};
OS   Erythrobacter litoralis (strain HTCC2594).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Erythrobacteraceae; Erythrobacter/Porphyrobacter group; Erythrobacter.
OX   NCBI_TaxID=314225 {ECO:0000313|EMBL:ABC63391.1, ECO:0000313|Proteomes:UP000008808};
RN   [1] {ECO:0000313|Proteomes:UP000008808}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTCC2594 {ECO:0000313|Proteomes:UP000008808};
RX   PubMed=19168610; DOI=10.1128/JB.00026-09;
RA   Oh H.M., Giovannoni S.J., Ferriera S., Johnson J., Cho J.C.;
RT   "Complete genome sequence of Erythrobacter litoralis HTCC2594.";
RL   J. Bacteriol. 191:2419-2420(2009).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Release of N-terminal proline from a peptide.; EC=3.4.11.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00001585,
CC         ECO:0000256|PIRNR:PIRNR006431, ECO:0000256|RuleBase:RU003421};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC       ECO:0000256|PIRNR:PIRNR006431}.
CC   -!- SIMILARITY: Belongs to the peptidase S33 family.
CC       {ECO:0000256|ARBA:ARBA00010088, ECO:0000256|PIRNR:PIRNR006431,
CC       ECO:0000256|RuleBase:RU003421}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000157; ABC63391.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2NAA0; -.
DR   STRING; 314225.ELI_06495; -.
DR   ESTHER; 9sphn-q2naa0; Proline_iminopeptidase.
DR   MEROPS; S33.001; -.
DR   KEGG; eli:ELI_06495; -.
DR   eggNOG; COG0596; Bacteria.
DR   HOGENOM; CLU_043739_2_2_5; -.
DR   OMA; FYQDGAS; -.
DR   Proteomes; UP000008808; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR002410; Peptidase_S33.
DR   InterPro; IPR005944; Pro_iminopeptidase.
DR   NCBIfam; TIGR01249; pro_imino_pep_1; 1.
DR   PANTHER; PTHR43722; PROLINE IMINOPEPTIDASE; 1.
DR   PANTHER; PTHR43722:SF1; PROLINE IMINOPEPTIDASE; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PIRSF; PIRSF006431; Pept_S33; 1.
DR   PRINTS; PR00793; PROAMNOPTASE.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|PIRNR:PIRNR006431,
KW   ECO:0000256|RuleBase:RU003421}; Cytoplasm {ECO:0000256|PIRNR:PIRNR006431};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR006431, ECO:0000256|RuleBase:RU003421};
KW   Protease {ECO:0000256|PIRNR:PIRNR006431, ECO:0000256|RuleBase:RU003421};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008808}.
FT   DOMAIN          47..305
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000259|Pfam:PF00561"
FT   ACT_SITE        119
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006431-1"
FT   ACT_SITE        274
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006431-1"
FT   ACT_SITE        302
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR006431-1"
SQ   SEQUENCE   325 AA;  36486 MW;  5165678881BE57ED CRC64;
     MANSNMLDYK RTLYPEIEPY ETGMLDVGEG HQLYYERVGT PGAKPAVFLH GGPGGGMAPS
     HRRQWDPELY DVLLFDQRGC GKSLPFAEIE HNDTWRIVAD IERLREMCGH EAWQVFGGSW
     GATLALAYAQ KHPERTTEIV LRGVFLARQN EKSWLYQYGA SEIMAEQWDE FSGHIPEAER
     DDLVQAYYAR LTSDDEPTRL AAAKQWSLWE GTVATLLPNA DLLADFEDPA KAVPFARICA
     RFFLENFYLE EGQLLRDMQS IGHIPTIIVQ GRHDICTPPG AAWAVKKAHP AAELWMVHDA
     GHSASEPGIV DGLVRATDQF ADKSK
//
DBGET integrated database retrieval system