ID   Q2NEA9_METST            Unreviewed;       704 AA.
AC   Q2NEA9;
DT   07-FEB-2006, integrated into UniProtKB/TrEMBL.
DT   07-FEB-2006, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   SubName: Full=Conserved hypothetical membrane-spanning protein {ECO:0000313|EMBL:ABC57844.1};
GN   OrderedLocusNames=Msp_1474 {ECO:0000313|EMBL:ABC57844.1};
OS   Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 /
OS   MCB-3).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanosphaera.
OX   NCBI_TaxID=339860 {ECO:0000313|EMBL:ABC57844.1, ECO:0000313|Proteomes:UP000001931};
RN   [1] {ECO:0000313|EMBL:ABC57844.1, ECO:0000313|Proteomes:UP000001931}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3
RC   {ECO:0000313|Proteomes:UP000001931};
RX   PubMed=16385054; DOI=10.1128/JB.188.2.642-658.2006;
RA   Fricke W.F., Seedorf H., Henne A., Kruer M., Liesegang H., Hedderich R.,
RA   Gottschalk G., Thauer R.K.;
RT   "The genome sequence of Methanosphaera stadtmanae reveals why this human
RT   intestinal archaeon is restricted to methanol and H2 for methane formation
RT   and ATP synthesis.";
RL   J. Bacteriol. 188:642-658(2006).
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DR   EMBL; CP000102; ABC57844.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2NEA9; -.
DR   STRING; 339860.Msp_1474; -.
DR   KEGG; mst:Msp_1474; -.
DR   eggNOG; arCOG09731; Archaea.
DR   HOGENOM; CLU_014010_0_0_2; -.
DR   Proteomes; UP000001931; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR007165; Phage_holin_4_2.
DR   InterPro; IPR002591; Phosphodiest/P_Trfase.
DR   Pfam; PF04020; Phage_holin_4_2; 1.
DR   Pfam; PF01663; Phosphodiest; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001931};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        284..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   704 AA;  79942 MW;  A4ACFBFA78F185B2 CRC64;
     MDVIGFSSRV MKYVLLLFVD VVLFLVFVSI FGGITVPSFV VAFIIVLLLS FFNGLLWPIL
     SYISLRFLVV TFGFGTFIFD GFILWILDMF IPGVSIGGMS LFTIPLLIAI INSFVSIVLD
     IHEDSLYYSS ILKKELQNSR GIRDKDGFIF LEIDGLAKDI LVEAIEKGDM PTLKSWIDEG
     SHILTSWETD LSSQTGASQA GILHGNNKDI PAFRWVEKEN NNRIVSSNGF SDSTYIENHI
     SNGRGLLSFN GASRSNLFSG DASDYILTFS KFASKRSLLT TTWYYLYSNP YFITRIIVLF
     MGDVCLELFS RIRQFVCSVY PRLRRNLSYF VARAGANVVM REATTISLIG DIFSGKYNVI
     YATYMGYDEI AHHSGIRDWD AFYALNHLDK QFRQLNRSIY ESGNNYHLVV LSDHGQSGGP
     TFKQKFGYTL EDLVSRNLPS NITVHSILHS NDDHFYESLG LKKYRGNKDR IDDTIEGIKF
     CIRDIKEKNS FKTLKKRYSI IDSDMPVFDK LRTLTEEVSS DFKLYDDIIT SNKTAQSIVL
     ASGNLGLIYF TDWSVRLTYE QIEDAFPGLL SSLASHNGIG FIMVKSAVYG SIVLCDDSIY
     YLDEDKYEGR PFLDKFGDNV ANHLRRTDSF EHVPDILVNS SYDEDTGEVY AFEELIGSHG
     GVGGLQQEPF ILYPSCWKLN NKIVGAENLH KFFKNEMLKF WDDD
//