GenomeNet

Database: UniProt
Entry: Q2NIM1
LinkDB: Q2NIM1
Original site: Q2NIM1 
ID   KITH_AYWBP              Reviewed;         209 AA.
AC   Q2NIM1;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 2.
DT   16-JAN-2019, entry version 66.
DE   RecName: Full=Thymidine kinase {ECO:0000255|HAMAP-Rule:MF_00124};
DE            EC=2.7.1.21 {ECO:0000255|HAMAP-Rule:MF_00124};
GN   Name=tdk {ECO:0000255|HAMAP-Rule:MF_00124};
GN   OrderedLocusNames=AYWB_605;
OS   Aster yellows witches'-broom phytoplasma (strain AYWB).
OC   Bacteria; Tenericutes; Mollicutes; Acholeplasmatales;
OC   Acholeplasmataceae; Candidatus Phytoplasma;
OC   Candidatus Phytoplasma asteris.
OX   NCBI_TaxID=322098;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AYWB;
RX   PubMed=16672622; DOI=10.1128/JB.188.10.3682-3696.2006;
RA   Bai X., Zhang J., Ewing A., Miller S.A., Jancso Radek A.,
RA   Shevchenko D.V., Tsukerman K., Walunas T., Lapidus A., Campbell J.W.,
RA   Hogenhout S.A.;
RT   "Living with genome instability: the adaptation of phytoplasmas to
RT   diverse environments of their insect and plant hosts.";
RL   J. Bacteriol. 188:3682-3696(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thymidine = ADP + dTMP + H(+);
CC         Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216;
CC         EC=2.7.1.21; Evidence={ECO:0000255|HAMAP-Rule:MF_00124};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABC65722.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; CP000061; ABC65722.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_041639918.1; NC_007716.1.
DR   ProteinModelPortal; Q2NIM1; -.
DR   SMR; Q2NIM1; -.
DR   STRING; 322098.AYWB_605; -.
DR   EnsemblBacteria; ABC65722; ABC65722; AYWB_605.
DR   KEGG; ayw:AYWB_605; -.
DR   eggNOG; ENOG4107T8J; Bacteria.
DR   eggNOG; COG1435; LUCA.
DR   HOGENOM; HOG000076390; -.
DR   KO; K00857; -.
DR   OrthoDB; 1279539at2; -.
DR   BioCyc; AYEL322098:G1G4I-624-MONOMER; -.
DR   Proteomes; UP000001934; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA synthesis; Kinase;
KW   Nucleotide-binding; Transferase.
FT   CHAIN         1    209       Thymidine kinase.
FT                                /FTId=PRO_0000242787.
FT   NP_BIND      16     23       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   NP_BIND      90     93       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   ACT_SITE     91     91       Proton acceptor. {ECO:0000255|HAMAP-
FT                                Rule:MF_00124}.
SQ   SEQUENCE   209 AA;  23466 MW;  B82A9EA00E668308 CRC64;
     MTQKEQGQGF IEVICGPMFA GKTESLIQRR NKALKLKKKI LSFKPRIDDR YSVKEEIVSH
     NRNNIPAILI DKSKDILTFI TPEINVVIID ESQFLDNDII AIVDYLANCN IEVIISGLEL
     DFCGKPFGPM PYLLAIADTV TKLTSICAIS GGKANRTQRL IEGKPAQSNE PVVLVGGKEY
     HEPRCRKHHC LADIDKTKVN WKNFANQSK
//
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