ID APC13_BOVIN Reviewed; 74 AA.
AC Q2NKV2;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 24-JAN-2024, entry version 98.
DE RecName: Full=Anaphase-promoting complex subunit 13;
DE Short=APC13;
DE AltName: Full=Cyclosome subunit 13;
GN Name=ANAPC13;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle. The
CC APC/C complex acts by mediating ubiquitination and subsequent
CC degradation of target proteins: it mainly mediates the formation of
CC 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By
CC similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: The mammalian APC/C is composed at least of 14 distinct
CC subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6,
CC ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and
CC ANAPC16 that assemble into a complex of at least 19 chains with a
CC combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1
CC and FBXO5. {ECO:0000250|UniProtKB:Q9BS18}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the APC13 family. {ECO:0000305}.
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DR EMBL; BC111620; AAI11621.1; -; mRNA.
DR RefSeq; NP_001106700.1; NM_001113229.2.
DR RefSeq; NP_001106705.1; NM_001113234.2.
DR RefSeq; XP_005201988.1; XM_005201931.3.
DR RefSeq; XP_005201989.1; XM_005201932.3.
DR RefSeq; XP_005201991.1; XM_005201934.3.
DR PDB; 5A31; EM; 4.30 A; M=1-74.
DR PDB; 5G05; EM; 3.40 A; M=1-74.
DR PDBsum; 5A31; -.
DR PDBsum; 5G05; -.
DR AlphaFoldDB; Q2NKV2; -.
DR EMDB; EMD-2925; -.
DR SMR; Q2NKV2; -.
DR DIP; DIP-61975N; -.
DR STRING; 9913.ENSBTAP00000019228; -.
DR PaxDb; 9913-ENSBTAP00000019228; -.
DR Ensembl; ENSBTAT00000019228.5; ENSBTAP00000019228.4; ENSBTAG00000014461.5.
DR GeneID; 614347; -.
DR KEGG; bta:614347; -.
DR CTD; 25847; -.
DR VEuPathDB; HostDB:ENSBTAG00000014461; -.
DR VGNC; VGNC:25881; ANAPC13.
DR eggNOG; ENOG502S4J1; Eukaryota.
DR GeneTree; ENSGT00390000008673; -.
DR HOGENOM; CLU_199969_0_0_1; -.
DR InParanoid; Q2NKV2; -.
DR OMA; PHDDIAV; -.
DR OrthoDB; 1330939at2759; -.
DR TreeFam; TF105448; -.
DR Reactome; R-BTA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000009136; Chromosome 1.
DR Bgee; ENSBTAG00000014461; Expressed in oocyte and 107 other cell types or tissues.
DR GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
DR InterPro; IPR008401; Apc13.
DR PANTHER; PTHR28672; ANAPHASE-PROMOTING COMPLEX SUBUNIT 13; 1.
DR PANTHER; PTHR28672:SF1; ANAPHASE-PROMOTING COMPLEX SUBUNIT 13; 1.
DR Pfam; PF05839; Apc13p; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; Cell division; Mitosis; Nucleus;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..74
FT /note="Anaphase-promoting complex subunit 13"
FT /id="PRO_0000253979"
FT REGION 33..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 9..15
FT /evidence="ECO:0007829|PDB:5G05"
FT HELIX 18..21
FT /evidence="ECO:0007829|PDB:5G05"
FT STRAND 34..36
FT /evidence="ECO:0007829|PDB:5G05"
FT HELIX 50..55
FT /evidence="ECO:0007829|PDB:5G05"
SQ SEQUENCE 74 AA; 8521 MW; F3C52A7E3821CB3B CRC64;
MDSEVQRDGR ILDLIDDAWR EDKLPYEDVA IPLNELPEPE QDNGGTTESV KEQEMKWTDL
ALQYLHENVP PIGN
//
