ID Q2NR29_SODGM Unreviewed; 432 AA.
AC Q2NR29;
DT 07-FEB-2006, integrated into UniProtKB/TrEMBL.
DT 07-FEB-2006, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE RecName: Full=Proton/glutamate-aspartate symporter {ECO:0000256|HAMAP-Rule:MF_02063};
GN Name=gltP {ECO:0000256|HAMAP-Rule:MF_02063};
GN OrderedLocusNames=SG2121 {ECO:0000313|EMBL:BAE75396.1};
OS Sodalis glossinidius (strain morsitans).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Bruguierivoracaceae; Sodalis.
OX NCBI_TaxID=343509 {ECO:0000313|EMBL:BAE75396.1, ECO:0000313|Proteomes:UP000001932};
RN [1] {ECO:0000313|EMBL:BAE75396.1, ECO:0000313|Proteomes:UP000001932}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=morsitans {ECO:0000313|Proteomes:UP000001932};
RX PubMed=16365377; DOI=10.1101/gr.4106106;
RA Toh H., Weiss B.L., Perkin S.A.H., Yamashita A., Oshima K., Hattori M.,
RA Aksoy S.;
RT "Massive genome erosion and functional adaptations provide insights into
RT the symbiotic lifestyle of Sodalis glossinidius in the tsetse host.";
RL Genome Res. 16:149-156(2006).
CC -!- FUNCTION: Catalyzes the proton-dependent transport of glutamate and
CC aspartate. {ECO:0000256|HAMAP-Rule:MF_02063}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_02063}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_02063}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass
CC membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. GltP subfamily. {ECO:0000256|HAMAP-
CC Rule:MF_02063}.
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DR EMBL; AP008232; BAE75396.1; -; Genomic_DNA.
DR RefSeq; WP_011411933.1; NC_007712.1.
DR AlphaFoldDB; Q2NR29; -.
DR STRING; 343509.SG2121; -.
DR KEGG; sgl:SG2121; -.
DR eggNOG; COG1301; Bacteria.
DR HOGENOM; CLU_019375_7_0_6; -.
DR OrthoDB; 9766690at2; -.
DR BioCyc; SGLO343509:SGP1_RS19580-MONOMER; -.
DR Proteomes; UP000001932; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005280; F:amino acid:proton symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006835; P:dicarboxylic acid transport; IEA:InterPro.
DR Gene3D; 1.10.3860.10; Sodium:dicarboxylate symporter; 1.
DR HAMAP; MF_02063; GltP_subfam; 1.
DR InterPro; IPR034703; GltP.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR42865; PROTON/GLUTAMATE-ASPARTATE SYMPORTER; 1.
DR PANTHER; PTHR42865:SF7; PROTON_GLUTAMATE-ASPARTATE SYMPORTER; 1.
DR Pfam; PF00375; SDF; 1.
DR PRINTS; PR00173; EDTRNSPORT.
DR SUPFAM; SSF118215; Proton glutamate symport protein; 1.
DR PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|HAMAP-Rule:MF_02063};
KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02063};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_02063};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_02063};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|HAMAP-Rule:MF_02063};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_02063};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_02063};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_02063}.
FT TRANSMEM 47..72
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02063"
FT TRANSMEM 84..106
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02063"
FT TRANSMEM 160..177
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02063"
FT TRANSMEM 206..227
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02063"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02063"
FT TRANSMEM 293..311
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02063"
FT TRANSMEM 323..350
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02063"
FT TRANSMEM 362..385
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02063"
FT TRANSMEM 391..409
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_02063"
SQ SEQUENCE 432 AA; 46226 MW; ED3C835CE3575332 CRC64;
MKKLKVTLAW QILFALILGI LLGAVLHNQG ELRDWMMANI LSPAGDIFIR MIKMIVVPIV
VATLVVGIAG IGDAKKLGSI GFKTILYFEI ITTLAIILGI TLANVFHPGY GIDMSTLAVV
DISKYEQTTV AVQSGGHSLV DTILSLIPAN IFASMAKGDM LPIIFFSVLF GLGLASLPEN
TRAPLLNVFN AVAETMFKVT HMVMRYAPVG VFALISVTVA TFGFASLLPL AKLVLLVYGA
IIFFALVVLG AVARLCRLRI WTLICILKEE LILAFSTASS ESVLPRIIEK MEAYGVPAAI
TGFVVPTGYS FNLDGSTLYQ SIAAIFIAQL YGIELSLGQE VVLVLTLMVT SKGIAGVPGV
SFVVLLATLG SVGIPLEGLA FIAGVDRILD MARTALNVVG NALAVLVIAK WENQYDSVQA
LAYEKEMLES RD
//
