GenomeNet

Database: UniProt
Entry: Q2PC93
LinkDB: Q2PC93
Original site: Q2PC93 
ID   SSPO_CHICK              Reviewed;        5255 AA.
AC   Q2PC93;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   10-APR-2019, entry version 86.
DE   RecName: Full=SCO-spondin;
DE   Flags: Precursor;
GN   Name=SSPO;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=CNS;
RA   Didier R.;
RT   "Characterization of SCO-spondin in chick embryos.";
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the modulation of neuronal aggregation. May
CC       be involved in developmental events during the formation of the
CC       central nervous system (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the thrombospondin family. {ECO:0000305}.
DR   EMBL; AJ866919; CAI29216.1; -; mRNA.
DR   RefSeq; NP_001006351.2; NM_001006351.2.
DR   UniGene; Gga.52789; -.
DR   ProteinModelPortal; Q2PC93; -.
DR   SMR; Q2PC93; -.
DR   STRING; 9031.ENSGALP00000007857; -.
DR   PaxDb; Q2PC93; -.
DR   PRIDE; Q2PC93; -.
DR   GeneID; 420367; -.
DR   KEGG; gga:420367; -.
DR   CTD; 23145; -.
DR   HOVERGEN; HBG080794; -.
DR   InParanoid; Q2PC93; -.
DR   OrthoDB; 12226at2759; -.
DR   PhylomeDB; Q2PC93; -.
DR   PRO; PR:Q2PC93; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR   CDD; cd00057; FA58C; 1.
DR   CDD; cd00112; LDLa; 12.
DR   Gene3D; 2.20.100.10; -; 23.
DR   Gene3D; 2.60.120.260; -; 1.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR030119; SCO-spondin.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   InterPro; IPR014853; Unchr_dom_Cys-rich.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339:SF358; PTHR11339:SF358; 18.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF00057; Ldl_recept_a; 12.
DR   Pfam; PF01826; TIL; 12.
DR   Pfam; PF00090; TSP_1; 25.
DR   Pfam; PF00093; VWC; 1.
DR   Pfam; PF00094; VWD; 3.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00832; C8; 3.
DR   SMART; SM00181; EGF; 9.
DR   SMART; SM00231; FA58C; 1.
DR   SMART; SM00192; LDLa; 13.
DR   SMART; SM00209; TSP1; 27.
DR   SMART; SM00214; VWC; 9.
DR   SMART; SM00215; VWC_out; 11.
DR   SMART; SM00216; VWD; 3.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF57424; SSF57424; 12.
DR   SUPFAM; SSF57567; SSF57567; 15.
DR   SUPFAM; SSF82895; SSF82895; 25.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS01285; FA58C_1; 1.
DR   PROSITE; PS01286; FA58C_2; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
DR   PROSITE; PS01209; LDLRA_1; 11.
DR   PROSITE; PS50068; LDLRA_2; 13.
DR   PROSITE; PS50092; TSP1; 27.
DR   PROSITE; PS01208; VWFC_1; 1.
DR   PROSITE; PS50184; VWFC_2; 2.
DR   PROSITE; PS51233; VWFD; 3.
PE   2: Evidence at transcript level;
KW   Calcium; Cell adhesion; Complete proteome; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Reference proteome; Repeat; Secreted;
KW   Signal.
FT   SIGNAL        1     18       {ECO:0000255}.
FT   CHAIN        19   5255       SCO-spondin.
FT                                /FTId=PRO_0000245045.
FT   DOMAIN       19    111       EMI.
FT   DOMAIN      193    395       VWFD 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN      453    508       TIL 1.
FT   DOMAIN      508    601       VWFC 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN      547    755       VWFD 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN      809    868       TIL 2.
FT   DOMAIN      868    926       VWFC 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN      999   1207       VWFD 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00580}.
FT   DOMAIN     1263   1319       TIL 3.
FT   DOMAIN     1362   1398       LDL-receptor class A 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1400   1436       LDL-receptor class A 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1439   1477       LDL-receptor class A 3.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1479   1515       LDL-receptor class A 4.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1515   1551       LDL-receptor class A 5.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1555   1593       LDL-receptor class A 6.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1616   1652       LDL-receptor class A 7.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1654   1693       LDL-receptor class A 8.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1699   1734       LDL-receptor class A 9.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1748   1790       LDL-receptor class A 10.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1789   1843       TSP type-1 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     1845   1903       TSP type-1 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     1907   1961       TIL 4.
FT   DOMAIN     1919   1956       EGF-like 1.
FT   DOMAIN     1957   1983       EGF-like 2.
FT   DOMAIN     1961   2019       VWFC 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN     2002   2058       TSP type-1 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2058   2120       VWFC 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN     2162   2310       F5/8 type C. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00081}.
FT   DOMAIN     2327   2362       LDL-receptor class A 11.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2481   2517       LDL-receptor class A 12.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2538   2574       LDL-receptor class A 13.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2575   2628       TSP type-1 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2630   2685       TSP type-1 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2708   2750       TIL 5.
FT   DOMAIN     2790   2844       TSP type-1 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2849   2903       TSP type-1 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     2905   2958       TSP type-1 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3020   3077       VWFC 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN     3060   3115       TSP type-1 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3117   3158       TSP type-1 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3165   3217       TIL 6.
FT   DOMAIN     3217   3275       VWFC 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN     3258   3309       TSP type-1 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3410   3475       TSP type-1 12. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3477   3532       TSP type-1 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3644   3700       TSP type-1 14. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3702   3751       TSP type-1 15. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3878   3934       TSP type-1 16. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     3951   4004       TSP type-1 17. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4018   4074       TSP type-1 18. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4076   4131       TSP type-1 19. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4230   4282       TSP type-1 20. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4322   4384       TSP type-1 21. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4386   4433       TSP type-1 22. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4537   4608       TSP type-1 23. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4610   4662       TSP type-1 24. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4762   4815       TSP type-1 25. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4817   4869       TSP type-1 26. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     4872   4926       TIL 7.
FT   DOMAIN     4979   5033       TSP type-1 27. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00210}.
FT   DOMAIN     5092   5150       VWFC 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00220}.
FT   DOMAIN     5161   5248       CTCK. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00039}.
FT   COMPBIAS    737    742       Poly-Ala.
FT   CARBOHYD     97     97       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    136    136       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    156    156       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    255    255       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    801    801       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    931    931       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    972    972       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1340   1340       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1610   1610       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1652   1652       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1713   1713       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1743   1743       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1856   1856       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2125   2125       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2230   2230       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2746   2746       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3011   3011       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3042   3042       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3065   3065       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3136   3136       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3238   3238       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3248   3248       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3350   3350       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3366   3366       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3392   3392       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3598   3598       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3625   3625       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3823   3823       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3869   3869       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4018   4018       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4174   4174       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4211   4211       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4362   4362       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4428   4428       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4498   4498       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4730   4730       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4747   4747       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4752   4752       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4867   4867       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4939   4939       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4970   4970       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   5081   5081       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   5122   5122       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   5169   5169       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID   1363   1376       {ECO:0000250}.
FT   DISULFID   1370   1389       {ECO:0000250}.
FT   DISULFID   1383   1397       {ECO:0000250}.
FT   DISULFID   1401   1413       {ECO:0000250}.
FT   DISULFID   1408   1426       {ECO:0000250}.
FT   DISULFID   1420   1435       {ECO:0000250}.
FT   DISULFID   1440   1452       {ECO:0000250}.
FT   DISULFID   1447   1465       {ECO:0000250}.
FT   DISULFID   1459   1476       {ECO:0000250}.
FT   DISULFID   1480   1492       {ECO:0000250}.
FT   DISULFID   1487   1505       {ECO:0000250}.
FT   DISULFID   1499   1514       {ECO:0000250}.
FT   DISULFID   1516   1528       {ECO:0000250}.
FT   DISULFID   1523   1541       {ECO:0000250}.
FT   DISULFID   1535   1550       {ECO:0000250}.
FT   DISULFID   1556   1568       {ECO:0000250}.
FT   DISULFID   1563   1581       {ECO:0000250}.
FT   DISULFID   1575   1592       {ECO:0000250}.
FT   DISULFID   1617   1629       {ECO:0000250}.
FT   DISULFID   1624   1642       {ECO:0000250}.
FT   DISULFID   1636   1651       {ECO:0000250}.
FT   DISULFID   1655   1668       {ECO:0000250}.
FT   DISULFID   1662   1681       {ECO:0000250}.
FT   DISULFID   1675   1692       {ECO:0000250}.
FT   DISULFID   1700   1711       {ECO:0000250}.
FT   DISULFID   1706   1724       {ECO:0000250}.
FT   DISULFID   1718   1733       {ECO:0000250}.
FT   DISULFID   1749   1759       {ECO:0000250}.
FT   DISULFID   1754   1772       {ECO:0000250}.
FT   DISULFID   1766   1789       {ECO:0000250}.
FT   DISULFID   1801   1837       {ECO:0000250}.
FT   DISULFID   1805   1842       {ECO:0000250}.
FT   DISULFID   1816   1827       {ECO:0000250}.
FT   DISULFID   1857   1897       {ECO:0000250}.
FT   DISULFID   1861   1902       {ECO:0000250}.
FT   DISULFID   1871   1881       {ECO:0000250}.
FT   DISULFID   2003   2042       {ECO:0000250}.
FT   DISULFID   2014   2018       {ECO:0000250}.
FT   DISULFID   2052   2057       {ECO:0000250}.
FT   DISULFID   2162   2310       {ECO:0000250}.
FT   DISULFID   2328   2339       {ECO:0000250}.
FT   DISULFID   2335   2352       {ECO:0000250}.
FT   DISULFID   2346   2361       {ECO:0000250}.
FT   DISULFID   2482   2494       {ECO:0000250}.
FT   DISULFID   2489   2507       {ECO:0000250}.
FT   DISULFID   2501   2516       {ECO:0000250}.
FT   DISULFID   2539   2551       {ECO:0000250}.
FT   DISULFID   2546   2564       {ECO:0000250}.
FT   DISULFID   2558   2573       {ECO:0000250}.
FT   DISULFID   2576   2612       {ECO:0000250}.
FT   DISULFID   2587   2591       {ECO:0000250}.
FT   DISULFID   2622   2627       {ECO:0000250}.
FT   DISULFID   2642   2679       {ECO:0000250}.
FT   DISULFID   2646   2684       {ECO:0000250}.
FT   DISULFID   2657   2669       {ECO:0000250}.
FT   DISULFID   2791   2829       {ECO:0000250}.
FT   DISULFID   2802   2806       {ECO:0000250}.
FT   DISULFID   2839   2843       {ECO:0000250}.
FT   DISULFID   2861   2897       {ECO:0000250}.
FT   DISULFID   2865   2902       {ECO:0000250}.
FT   DISULFID   2881   2887       {ECO:0000250}.
FT   DISULFID   2917   2952       {ECO:0000250}.
FT   DISULFID   2921   2957       {ECO:0000250}.
FT   DISULFID   2932   2942       {ECO:0000250}.
FT   DISULFID   3061   3099       {ECO:0000250}.
FT   DISULFID   3072   3076       {ECO:0000250}.
FT   DISULFID   3109   3114       {ECO:0000250}.
FT   DISULFID   3270   3303       {ECO:0000250}.
FT   DISULFID   3274   3308       {ECO:0000250}.
FT   DISULFID   3285   3293       {ECO:0000250}.
FT   DISULFID   3422   3468       {ECO:0000250}.
FT   DISULFID   3426   3474       {ECO:0000250}.
FT   DISULFID   3437   3449       {ECO:0000250}.
FT   DISULFID   3489   3524       {ECO:0000250}.
FT   DISULFID   3492   3531       {ECO:0000250}.
FT   DISULFID   3502   3514       {ECO:0000250}.
FT   DISULFID   3656   3693       {ECO:0000250}.
FT   DISULFID   3660   3699       {ECO:0000250}.
FT   DISULFID   3671   3683       {ECO:0000250}.
FT   DISULFID   3714   3745       {ECO:0000250}.
FT   DISULFID   3718   3750       {ECO:0000250}.
FT   DISULFID   3729   3735       {ECO:0000250}.
FT   DISULFID   3890   3928       {ECO:0000250}.
FT   DISULFID   3894   3933       {ECO:0000250}.
FT   DISULFID   3906   3918       {ECO:0000250}.
FT   DISULFID   3963   3998       {ECO:0000250}.
FT   DISULFID   3967   4003       {ECO:0000250}.
FT   DISULFID   3982   3988       {ECO:0000250}.
FT   DISULFID   4019   4055       {ECO:0000250}.
FT   DISULFID   4030   4034       {ECO:0000250}.
FT   DISULFID   4068   4073       {ECO:0000250}.
FT   DISULFID   4088   4125       {ECO:0000250}.
FT   DISULFID   4092   4130       {ECO:0000250}.
FT   DISULFID   4103   4115       {ECO:0000250}.
FT   DISULFID   4231   4266       {ECO:0000250}.
FT   DISULFID   4242   4246       {ECO:0000250}.
FT   DISULFID   4276   4281       {ECO:0000250}.
FT   DISULFID   4387   4417       {ECO:0000250}.
FT   DISULFID   4398   4400       {ECO:0000250}.
FT   DISULFID   4427   4432       {ECO:0000250}.
FT   DISULFID   4548   4601       {ECO:0000250}.
FT   DISULFID   4551   4607       {ECO:0000250}.
FT   DISULFID   4575   4591       {ECO:0000250}.
FT   DISULFID   4611   4646       {ECO:0000250}.
FT   DISULFID   4622   4626       {ECO:0000250}.
FT   DISULFID   4656   4661       {ECO:0000250}.
FT   DISULFID   4774   4809       {ECO:0000250}.
FT   DISULFID   4778   4814       {ECO:0000250}.
FT   DISULFID   4789   4798       {ECO:0000250}.
FT   DISULFID   4818   4852       {ECO:0000250}.
FT   DISULFID   4829   4833       {ECO:0000250}.
FT   DISULFID   4863   4868       {ECO:0000250}.
FT   DISULFID   4980   5017       {ECO:0000250}.
FT   DISULFID   4991   4995       {ECO:0000250}.
FT   DISULFID   5027   5032       {ECO:0000250}.
FT   DISULFID   5161   5209       {ECO:0000250}.
FT   DISULFID   5175   5226       {ECO:0000250}.
FT   DISULFID   5185   5242       {ECO:0000250}.
FT   DISULFID   5189   5244       {ECO:0000250}.
FT   DISULFID      ?   5247       {ECO:0000250}.
SQ   SEQUENCE   5255 AA;  560556 MW;  DBE892EA9AA0378B CRC64;
     MGIVATVLLW VVTEAARGRW CERTEQVTEE EVVMPRREDV VPCPSMYQYS LAGWRIDLNR
     MRQVYGGERG VPPTSTHPGA AMCYIYRPPE TQLVVRNRTV RACCAGWSGP HCTEVEGSLG
     QCHASWQCQD ALGAHNLSTV SMAECCRQPW GHSWRNGSSA LCFACSRQPL TGDVPLPTAP
     RGPAARHRGP TASCTVWAGS RYRSFDGRHF GFQGECAYSL AASTDSTWAV SITPGSPPVL
     HMTFGLDTVV AQGHNISVNG VAVPEGRQHL HGGISVTWLG DFVAVESGLG VHLKLDGRGT
     VYVTVSAELR GSTKGLCGPY NDDPIDDFLR VEGDVAPLAA SFGNSWRIPD ANPELSCSDA
     VEPSPGCAMG STAQRAAEAM CGMLLTDPFR QCHEAVDPHG FYEACLELHC REGGTGPSPP
     PAVCDTLATY VRDCAQRRAY IEWRRPGLCE QQCGHGQRYS DCVSSCPASC MAAGTAEEGH
     CRDDCASGCE CTPGLLLDRG ACIPQSACPC LHRGHIYAPG QSIRQRCNQC TCRGGRWLCT
     QDRCAAECAV LGDLHYITFD RRRFSFPGAC EYTLVQDFVE GTLRITAEQE ACGGHQPLSC
     LRALSITVPG ASARLHSTGE VVVDGRVVPL PFASAALTVR RASSSFLLLQ TFGAHLLWGL
     ETPAAYITLQ PAFANKVRGL CGTYNWDQRD DFATPAGDVE VGVTAFANKY RVSTDCPVLS
     PVPFEPCSTY APRRELAAAA CAILHGASFQ PCHHLVDREP FHQLCLYDVC ACPAGKHCLC
     PALAAYAREC AQEGAALSWR NESFCGTQCR GGQVYQECSS PCGRTCADLR LDGASSCPSL
     DNICVSGCNC PEGPVLDDGG QCVPPGVCPC QHSSQLYPAG SKIRQGCNAC MCTAGTWSCT
     DAPCPDAAFC PGDLVYVFGS CLRTCDSAEP NGTCTGIADG CVCPPGTVFL DERCVPPEEC
     PCQHNGRLYH PNDTIVRDCN TCVCRQQRWQ CSSEDCMGTC VATGDPHYIT FDGRAFSFLG
     DCEYVLVREA NGLFTVTAEN VPCGTSGVTC TKSVVVEMGN TVVHMLRGRD VTVNGVSVRP
     PKVYSGNGLT LQRAGIFLLL LSRLGLAVLW DGGTRVYIRL QPQHRGRVVG LCGNFDRDAE
     NDLASQQGVL EPTAELFGNS WRVSLLCPEV DGTTAQHPCT DNPHRATWAR KRCSILTQRL
     FAPCHDEVPC QHFYDWCIFD ACGCDSGGDC ECLCTAIATY AEECSQRGIH IRWRSQDLCP
     MQCDGGQEYS ACGPPCPQTC RNLGLELPEH CDTMSCLEGC FCPEGKVLHE GSCIDPAECP
     CFWQGIAFPD SAVVQQGCRN CSCTAGLWQC VPTAEPCPAQ PHCPDSEFPC RSGGRCVPGA
     WLCDNEDDCG DGSDEVCALH CAPHQHRCAD GQCVPWGARC DGLSDCGDGS DERGCPPPPC
     APPEFRCASG RCIPRAHVCN GELDCGFADD SDEAGCSPSC SVGEFQCAAG RCVPYPHRCN
     GHDDCGDFSD ERGCVCPAGH FQCPDAQCLP PAALCDGMQD CGDGTDEAFC PDRITCAPGQ
     LPCPDGSCVS QVKLCDGIWD CRDGWDESSV RCMVSWAPPA PTQLPTVPAN GTAAPVCGPY
     EFPCRSGQCV PRGWVCDSEA DCPDNSDELG CNRSCVLGHF PCALGAHCIH YDHLCDGIPH
     CPDHSDESDD NCGSTQIPPC PGHFVCNNRV CVNATRVCDG ALDCPQGEDE LACEGYVPTG
     ERNQTVGPCA EYSCRDGDCI TFKQVCNGLP DCRDGDMASG WLPSDEWDCG QWGPWAPWGI
     CSHSCGLGQQ LRARECSQRT PGVLHQCHGE ATQARPCFST ACPVDGAWSE WTMWSNCTQG
     CEGVVVRQRH CQPPRDGGRP CAALPATAHA TLEIGTCQQD GCPPASCPGG LQPRPCAPCP
     ASCADLASRA PCRREQCTPG CWCAEGLVLD GERGCVRPRE CRCEVDGLRY WPGQRMKLNC
     RLCTCLDGQP RRCRHNPACS VSCSWSAWSP WGECLGPCGV QSIQWSFRSP SHPGKHGTNR
     QCRGIYRKAR RCQTEPCQEC EHQGRSRAQG DRWRWGPCHV CQCLPGPEVR CSPYCARSAV
     GCPQGQVLVE GKGDSCCFCA QIGDNVTAIP TALTMEPPST MPGEPSDSPL PTFPLPSPGD
     PCYSPLGIAS LPDSSFTASA EQQQHPARAA RLHHVSPGLE LQGWAPPADT VPGLPSHLPF
     LQLDLLQTTN LTGVVVQGAG AGDAFITAFQ LQFSTDGNRW HNYQQLFQGN WDATTPVVQP
     LDHMVQARYI RILPQGFHNA IFLRAELLGC PTVPLDLAVT TAVTPAPCGT GEFWCGVSCV
     TASRRCDGAT DCPGGADEAG CEPPSSTTLP THPASLTTPG SAGILGLTAE PPVAPPAAVP
     EGTSAWLTVG STSPAVPSTT GLPGVPTATI TPRGPPSAGP PSPGMAAVTV SHPVMGPPAL
     PMPPTGVPTP TSAEPPLPRL LCPPDQFLCD ALGCVDAAMV CDGQQDCLDG SDEAHCGALP
     TSGSSPSPLA WPSSPPPTCS PKQFSCGTGE CLALEKRCDL SRDCADGSDE SSCADCILSP
     WGGWSQCSHS CGLGVTSRQR VLLRGALPGG TCHTPRLDTR ACFLRACPVP GAWAAWGVWS
     SCDAECGGGM RSRTRSCTDP PPKNGGQPCA GEALQSQPCN LQPCGDTREC GPGMVLVQEG
     DCVQGLVPPC PQVCGDLSAT SSCQSPCQEG CRCPPGLFLQ EGTCVNASQC HCHQGQQRWL
     PSQVFLRDGC SQCVCRDGVV TCEDTACPIA CAWSAWSLWT LCDRSCGVGM QERFRSPSNP
     AAANGGAPCD GDTREVRECH TPCATAEPSS GWSSWTPWSP CSRSCFHHVD QRGRRHRFRH
     CEGMGTCPGL GVQEEPCDTA PCPVAGVWMP WSAWSECSAP CDAGVQTRSR TCTPPAFGGA
     ECTGPHLQTR NCNTRPCGAQ CPDTMQYLTA EECRHSEGRC PWICQDLGAG VACTAQCQPG
     CHCPAGLLLQ NGTCVPPSHC LCHHRGHLYQ PGDINALDTC NNCTCVTGQM VCSTETCPVP
     CTWSNWTAWS TCSHSCDVGM RRRYRVPIVP PLAGGGPPCQ GPSMEVEFCS LQPCRAVAPW
     GPWSECSVSC GGGYRNRTRD GPPLHSLEFS TCNPAPCPGK EPGVCPPGKQ WQACAQGAAS
     CAELSAAPPA DGSCHPGCYC PPGALLLNNE CVAEAACPCA VDGVLYQPGD VVPQGCHNCS
     CIAGRVTNCS QEDCGDVDGP WTPWTPWSEC SASCGPGRQR RYRFCSAHPG VPCAEPQPQE
     RPCARQPCHS PDCAAVPGSV FSHCRPPCPR SCDDISHCVW HRQPGCYCTN GTLLDATGTA
     CVALENCTCL DAHSGQRHQP GQSVPRGDGC NNCTCTQGRL LCTGLPCPVP GAWCEWSPWT
     PCSRSCGDEA ATRHRVCSCP APQQGGAGCP GGLEGHGDTG MQLQHQECPS VPPCPEDGAW
     AAWGPWSGCG GCGGQAVRTR SCSSPPARFG GLPCAGEARQ SRACPWATSS CPECAGGLVA
     FTCGKPCPHS CEDLREDTAC MATPRCLPAC ACPHGQLLQD GDCVPPELCR CAWAPSKNGS
     IWEQDGAVPM QELQPGETVQ RHCQNCTCKS GTLQCHAEPG CRADGGWSPW GPWSPCSPGC
     QAGTQLASRQ CNNPTPQLGG RGCSGHSQRQ RPCPATEGCP EEEPWGEWSP WGPCSASCGG
     GEQLRHRDCP PPGGCPGLAL QSKTCNTHVC REAGCPPGRL YRECQQGEGC PYSCAHLAGR
     IACFPGGCQE GCHCPTGTLL HHGHCLQECP CVLTAEVLRK LRNSSADLQA APHLLGTRGP
     PLALDQELPP GSTIHSACTS CTCLHGRLNC SEPVCPRDGG FSPWGPWSSC SRSCGGLGVM
     TRRRGCTNPE PARGGRDCAG PRSDSKYCQS PECPAVPTTE PGPGVAGAEE EEGFGPWSPW
     SPCSKTCTHP ERPATKTRER PCVGTAVCSG DGFQEQPCNL PLCSDVPPCQ GEDCAGLNCS
     WAPWGPWTEC SRSCGVGRQQ RLRAYSPPGA SGRWCPGILS AFVQRRFCSL QACKVDGAWS
     AWSPWSRCDR TCGGGRAVRT RSCTRPPPKN GGQRCPGERH QLHLCNAQPC DDSCPPGMAL
     VTCANHCPRH CGDLQEGIVC REEEHCEPGC RCPNGTLEQD GGCVPLAHCE CTDAQGHGWV
     PGSTHHDGCN NCTCLEGRLR CTDRLCPPLR CPWSRWSRWS PCSVTCGDGQ QTRFRTPTAG
     SWDEECQGEQ MENRGCAAGP CPPLCPQGSW ERRLGDMWLQ GECQRCTCTP EGTVCEDTTC
     AGAEHCTWGT WSPCSRSCGT GLASREGSCP CPFPGPPGAV CNASTGDGAR PHREVQACYL
     RPCPAECSWS AWSSWGGCSC SSPLQHRYRH RHGTGLCVGL DVELHPCNTS GCSESSCEPP
     FEFQPCSPPC ARLCSTLQHP ELCPAQSHCL PGCFCPQGLL EQRSACVPPE QCDCLHTNES
     GDLVTLSPGD IILLGCKECV CQDGALQCSS EGCQGLLPLS PWSEWTPCST CLPLFPSHLG
     DATPHVSVQH RYRACLDPQS GQPWSGDTAV CSAELQQQRL CPDPDICQEL CLWSPWGPWG
     PCQQPCSGSF RLRHRHLQRL AGSGQCQGAQ TQSESCNTAV CPGEDCEKQG RVFATTCANS
     CPRACADLWQ HVECVQGGCK PGCRCPQGQL LQDGLCVPTA QCRCGLSGDN GTQELWPGQE
     ATIECHNCTC ENGTMVCPAL PCPSYGPWST WSPCSSSCGS GRTSRHRTCE PNPGGVPCMA
     SGMQETAECS PQPCPAGCQL SPWSPWSPCS SSCGGGRSER SRELLGGEEE PCPIPALRQH
     RVCNVHNCTQ ECPRSQVHRE CANACPHACA DLRPQTQCLP QPCQPGCACP PGQVLQDGAC
     VPPEECRCTL DSTMPGVLNL SREEQEQEHA PGSRLQHRCN TCICIRGTFN CSQEECNVDC
     LWSPWSPWSP CSVTCGMGER LSHRHPLRQR LYEGAECLGP PVRRAACHLP DCACPEGERW
     QGHEVPPGCE QSCRDILDET PANCTPSPSP GCTCEPGHYR NSSGHCVPST LCECLHQGQL
     HQPGSEWQEQ CARCRCVDGK ANCTDGCTPL SCPEGEVKVR EPGRCCPVCR MEWPEEPSSM
     CRRFTELRNI TKGPCSLPNV EVSFCSGRCP SRTAVTPEEP YLQTLCECCS YRLDPGSPVR
     ILSLPCAGGA AEPVVLPIIH SCECSSCQGG DFSKR
//
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