ID Q2PDM3_DROME Unreviewed; 2289 AA.
AC Q2PDM3; H9XVM2;
DT 07-FEB-2006, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2013, sequence version 3.
DT 27-MAR-2024, entry version 151.
DE SubName: Full=Uncharacterized protein, isoform C {ECO:0000313|EMBL:AFH06767.1};
DE SubName: Full=Uncharacterized protein, isoform E {ECO:0000313|EMBL:ABC65827.3};
GN Name=FBgn0053978 {ECO:0000313|EMBL:ABC65827.3};
GN Synonyms=Dmel\CG33978 {ECO:0000313|EMBL:ABC65827.3};
GN ORFNames=CG33978 {ECO:0000313|EMBL:ABC65827.3,
GN ECO:0000313|FlyBase:FBgn0053978}, Dmel_CG33978
GN {ECO:0000313|EMBL:ABC65827.3};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ABC65827.3, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:ABC65827.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:ABC65827.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:ABC65827.3, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:ABC65827.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:ABC65827.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:ABC65827.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:ABC65827.3}
RP NUCLEOTIDE SEQUENCE.
RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S.,
RA Svirskas R., Rubin G.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:ABC65827.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [9] {ECO:0000313|EMBL:ABC65827.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
RN [10] {ECO:0000313|EMBL:ABC65827.3}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109357; DOI=.1534/g3.115.018929;
RG FlyBase Consortium;
RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E.,
RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M.,
RA Gelbart W.M., null;
RT "Gene Model Annotations for Drosophila melanogaster: Impact of High-
RT Throughput Data.";
RL G3 (Bethesda) 5:1721-1736(2015).
RN [11] {ECO:0000313|EMBL:ABC65827.3}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26109356; DOI=.1534/g3.115.018937;
RG FlyBase Consortium;
RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E.,
RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M.,
RA null;
RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders.";
RL G3 (Bethesda) 5:1737-1749(2015).
RN [12] {ECO:0000313|EMBL:ABC65827.3}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25589440;
RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E.,
RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M.,
RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M.,
RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M.,
RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M.,
RA Karpen G.H., Celniker S.E.;
RT "The Release 6 reference sequence of the Drosophila melanogaster genome.";
RL Genome Res. 25:445-458(2015).
RN [13] {ECO:0000313|EMBL:ABC65827.3}
RP NUCLEOTIDE SEQUENCE.
RG Berkeley Drosophila Genome Project;
RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R.,
RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C.,
RA Rubin G.;
RT "Drosophila melanogaster release 4 sequence.";
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:ABC65827.3}
RP NUCLEOTIDE SEQUENCE.
RG FlyBase;
RL Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AE014135; ABC65827.3; -; Genomic_DNA.
DR EMBL; AE014135; AFH06767.1; -; Genomic_DNA.
DR RefSeq; NP_001033801.3; NM_001038712.3.
DR RefSeq; NP_001245407.1; NM_001258478.1.
DR AlphaFoldDB; Q2PDM3; -.
DR IntAct; Q2PDM3; 1.
DR STRING; 7227.FBpp0300571; -.
DR PaxDb; 7227-FBpp0300571; -.
DR EnsemblMetazoa; FBtr0308251; FBpp0300571; FBgn0053978.
DR EnsemblMetazoa; FBtr0310436; FBpp0302584; FBgn0053978.
DR GeneID; 3885646; -.
DR KEGG; dme:Dmel_CG33978; -.
DR UCSC; CG33978-RA; d. melanogaster.
DR AGR; FB:FBgn0053978; -.
DR FlyBase; FBgn0053978; CG33978.
DR VEuPathDB; VectorBase:FBgn0053978; -.
DR eggNOG; ENOG502REJ9; Eukaryota.
DR HOGENOM; CLU_000923_0_0_1; -.
DR InParanoid; Q2PDM3; -.
DR OMA; MYVSDST; -.
DR OrthoDB; 5406811at2759; -.
DR BioGRID-ORCS; 3885646; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 3885646; -.
DR Proteomes; UP000000803; Chromosome 4.
DR Bgee; FBgn0053978; Expressed in larva and 18 other cell types or tissues.
DR ExpressionAtlas; Q2PDM3; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR031866; DUF4758.
DR PANTHER; PTHR39072:SF2; -; 1.
DR PANTHER; PTHR39072; RE48511P; 1.
DR Pfam; PF15950; DUF4758; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 917..953
FT /note="DUF4758"
FT /evidence="ECO:0000259|Pfam:PF15950"
FT DOMAIN 1054..1235
FT /note="DUF4758"
FT /evidence="ECO:0000259|Pfam:PF15950"
FT REGION 1276..1308
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1412..1435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1468..1591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1671..1707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1723..1828
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2142..2172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1276..1306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1468..1486
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1487..1501
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1528..1570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1723..1742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1743..1757
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1758..1820
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2289 AA; 256533 MW; CEAD396F1BD82467 CRC64;
MLQPREDNKI SDIFHKKYDT STSTRRMMYS TYYNFNLSRV LFTTLLFTMM HIETSHAINQ
SYHVSPTPTL PAISGDDITT VLLVNNESGH MGDFHGRFLT VRPEIGVLKS TARTFIQDGI
TTEFATKIVG TTLNNGRLYA QYLKKSSRVL YENENISPSV VTSWVGEEDS LQTPLVLQSH
NDLFNIDDSN WQDIDDSIGA HQREFVGNTD FVNEQNTKNK VLEAPALQDK KTISYMGSDS
NDTLRTDFKK EDEINRLIEV LSIKHLETYT VKMPFGNYPT SSLNQSHLDH RKERKYEHLM
QPHTEKKNED HNQKSRSDHK QVLASVTYYG FADFTTIVGD SVIVFSPSTT QSILHYGHVT
SIKGKPTLQH DLIPEEIAQT SKISLSTLKM GTSSGKYEEF VSNISASKMF DKNELKNLSV
LKPTNPSPTF ANNSFNEEQE ASSVLSKDIV PFVSKAFNDI ISPSFVNGVK EGTKHNEPSI
IKQEGATTVF IDDDPFTSFD DLSGSTSLKL NSANEIKSIK SFEMSKSDEI REIVAYQTNI
NFTKDSLDIN PLFETSNENH DFEELCNHTT SQVFLTQMSK ANISNEKNSM DTIDIDANPL
HAYEIVETTK YYCIQASQSK QTPELDIIVT HETFTKSRGE FVSTYSIDDD IDETTVQDLG
DYEGTTENEY ESEEEEYESV SDEVDLIYKT LYTTYTYLTT FFEGSRTTIS SHTEVLTNIV
SSTLLPKAKL KSNTLNYVGE NQISDNTIRL IDHKTTEFSQ KYSIPDEIAS LLIQESKVNT
AESSSQMMTT LRDDLIYSKT LLTTYTYYTS IFTNNETEVQ SRTEIVTNYI TDNVSNNETN
FIRNPQTANL NFLKSQHSLV EEKIDKVVNM AYGMSVNSSM LRDSSPASFI NQNLLDDQVS
SESNTEEIIP SATFLLQTSF TTFTFYTTMY VGNDTSIISR HETITNVATE ALHPTKLISV
EDYSLPITYF TTFTYWTKLA KDGEITTLSR EETLSNVIQH SNGTTLTVND LKTADKVSSQ
STATDSDTEN DRNCKSESSL FSTLENQIYQ SDITTFYTTY TYYTTSYDVN TTIIDSRLET
VTNIITSREM SNPMEETDAT ILMIKPSQPI AYYENPIETI KPNVVLYDYK QIIDAENIST
LYFTTEIVSS MNSEGYAIKL TSSTSRLHVD QSKKSRMSTI YGKIPDDSLN LYKTGLVRLI
EGKRIQNSTT TLYQSRVIGT LIENRYAQII ESTSSFFFEK TKSEHILFPT SVEISGMITK
NVDLIDVIES TKSENDTTVA PYIDQKNTKP ESDNTDGLSN HSPQNAKRPF APVIRPFASR
NRPTFAPKQK TLVPSSATII TRSDITPTIT ATPALKAVGR YTASRRGIIS NVPINLNEPN
LSQSSQSSRR LFGRPSKSMY DLIEANSTLQ SSNAFSPSKT RFTSPLRPGV SSRRPNINIS
YRSSSFPVFR GSGVIANTRL RIKPTSIGIQ SSYRPTQSTT FATESSSEDS VEEDTSPDEE
SDVEEGIKNN NNSPLLRFRR PINAPSGFSP PIRQTGNSPV VSLRRNPLSP RAKISTTTSS
TTTTTAKPRA RSFQRPIGPH PRSRPQNTLF PPRGLFQTQI KNENLKVPRT NDSVPNNDFE
YEGGVEDQDL DENIHRRKRS IKYSVRFTTG NRVRRQADTV RRNRFRFRRQ NQTATTKVES
KLMDSDNNTE PILTPRDKSS SRFGSRFHSP QVHQLYTQAL IAESPTATNH RSIRPSRPTT
KRPQFTLREK DANLKGTASK NFRRQPASGN SRRPVGNSGN SNSRRLKSYV SYNKNNLDNG
RPSSSPRSRN SNSNTLNRGR SRGRNRVDYA SDVQSVENDL QTITVTHYIP SEVTVPVVSG
HITEYKSIVT AKSSTEIVGP NDFAVVLGSN GISSTYLNRE TSIINIAGAT EHTKYLLHES
ITSSVTFTPT TIRGRKTSFS HIIPSTAYSV EYIVTTMQPQ ISENAPLANI LLSQLLLGNL
NLPAHPLIGA VGQQNVPSTI IPTSVEPITE YRTHTSTYVT TIFDGKSTIL PVTFQGKKIL
TTVYDTTAQT ITATEYSVDT IINTLPSVQS VHTVGPAAHV NNLLLQQLLI QQQHESLVQA
ISNPTPPQVL LSENLQVLDD GTRTSIKSDA IDIEYDSDLV SVSNESQPTK GHRKKSRKSS
SGNKRSKQEP SVITLYVSGR RPGEFSTVLS TVKNEHDHSV SLQKRHAVLE IQPTNSIKYV
SSIERSKNIM EKNDILRDIR SSLTIDIGFN DLPDQTASLE SIVGDVDLWF ANSNRQSSTV
TTFIKSVVV
//
