ID Q2PRD8_DANRE Unreviewed; 313 AA.
AC Q2PRD8; A0A8M1NI23;
DT 24-JAN-2006, integrated into UniProtKB/TrEMBL.
DT 24-JAN-2006, sequence version 1.
DT 27-MAR-2024, entry version 127.
DE SubName: Full=Odorant receptor {ECO:0000313|EMBL:ABC43329.1, ECO:0000313|Ensembl:ENSDARP00000071435, ECO:0000313|RefSeq:NP_001121889.1};
GN Name=or71ar1 {ECO:0000313|ZFIN:ZDB-GENE-070806-82};
GN Synonyms=or118-3 {ECO:0000313|RefSeq:NP_001121889.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070806-82};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:ABC43329.1};
RN [1] {ECO:0000313|RefSeq:NP_001121889.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15824306;
RA Niimura Y., Nei M.;
RT "Evolutionary dynamics of olfactory receptor genes in fishes and
RT tetrapods.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:6039-6044(2005).
RN [2] {ECO:0000313|EMBL:ABC43329.1}
RP NUCLEOTIDE SEQUENCE.
RA Alioto T.S., Ngai J.;
RT "The odorant receptor repertoire of teleost fish.";
RL BMC Genomics 6:173-173(2006).
RN [3] {ECO:0000313|RefSeq:NP_001121889.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16332259;
RA Alioto T.S., Ngai J.;
RT "The odorant receptor repertoire of teleost fish.";
RL BMC Genomics 6:173-173(2006).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000071435}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000071435};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [5] {ECO:0000313|Ensembl:ENSDARP00000071435, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000071435};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6] {ECO:0000313|RefSeq:NP_001121889.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26108469;
RA Saraiva L.R., Ahuja G., Ivandic I., Syed A.S., Marioni J.C.,
RA Korsching S.I., Logan D.W.;
RT "Molecular and neuronal homology between the olfactory systems of zebrafish
RT and mouse.";
RL Sci. Rep. 5:11487-11487(2015).
RN [7] {ECO:0000313|RefSeq:NP_001121889.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29020985;
RA Shao X., Lakhina V., Dang P., Cheng R.P., Marcaccio C.L., Raper J.A.;
RT "Olfactory sensory axons target specific protoglomeruli in the olfactory
RT bulb of zebrafish.";
RL Neural Dev. 12:18-18(2017).
RN [8] {ECO:0000313|RefSeq:NP_001121889.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29551974;
RA Han Y., Zheng Y., Zhang J., Hu C.;
RT "Neurobehavioral Effects of Cephalosporins: Assessment of Locomotors
RT Activity, Motor and Sensory Development in Zebrafish.";
RL Front. Pharmacol. 9:160-160(2018).
RN [9] {ECO:0000313|RefSeq:NP_001121889.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AL928851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DQ306088; ABC43329.1; -; Genomic_DNA.
DR RefSeq; NP_001121889.1; NM_001128417.1.
DR RefSeq; XP_009289884.1; XM_009291609.2.
DR STRING; 7955.ENSDARP00000071435; -.
DR PaxDb; 7955-ENSDARP00000071435; -.
DR Ensembl; ENSDART00000076967.5; ENSDARP00000071435.3; ENSDARG00000054719.5.
DR GeneID; 100151390; -.
DR KEGG; dre:100151390; -.
DR AGR; ZFIN:ZDB-GENE-070806-82; -.
DR CTD; 100151390; -.
DR ZFIN; ZDB-GENE-070806-82; or71ar1.
DR HOGENOM; CLU_012526_0_1_1; -.
DR OMA; AFMQSNI; -.
DR OrthoDB; 4118840at2759; -.
DR TreeFam; TF333738; -.
DR Proteomes; UP000000437; Chromosome 15.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR PANTHER; PTHR26451; G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR26451:SF854; ODORANT RECEPTOR-RELATED; 1.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:ABC43329.1, ECO:0000313|RefSeq:NP_001121889.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..290
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 313 AA; 36121 MW; E0BBA4E94A6693A7 CRC64;
MYPNESVLSV VLTLHSLELP QMSIYPVLTF GIMTYLIVLL CNLTIIVTIC LNRNLHKPMY
ILLLNLPIND TMGSTSLFPH LLYSIWSQDR SITYSACLTQ GFFIHFYGGA SHVILMVMAF
DRYIAICLPL RYGAIMTPSN LMRIISVMWF IHFVIIFVLF CLLMPHRICQ TYMADLICYN
PSLMKIMCED TTVNNMYGLF ILSLYHSLPL SVVAFTYIHI LVTCVTNRQS DAKMKALQTC
GTHLVVFLFL EFNTLFPLIA HRAESIPAHL RRVFSISVVI FPPIVNPLIY GFKTKEIRQK
IENFYKRKII RVH
//
